SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7BZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		6 / 12 GLY A 108
GLY A 109
SER A 188
TRP A 221
PHE A 276
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 0.98A 1dx6A-5thmA:
40.4		 1dx6A-5thmA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 GLY A 190
GLY A 108
GLY A 109
PHE A 113
HIS A 445
 None
7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.98A 1dx6A-5thmA:
40.4		 1dx6A-5thmA:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.38A 1fohA-5thmA:
undetectable		 1fohA-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1fohC-5thmA:
undetectable		 1fohC-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.38A 1fohD-5thmA:
undetectable		 1fohD-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 THR A  86
VAL A  87
SER A  88
GLY A 109
ALA A 115
 None
None
None
7BZ  A 601 (-3.0A)
None
 1.09A 1jg4A-5thmA:
undetectable		 1jg4A-5thmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1pn0C-5thmA:
undetectable		 1pn0C-5thmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1pn0D-5thmA:
undetectable		 1pn0D-5thmA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 11 GLY A 108
GLY A 109
SER A 188
PHE A 113
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.95A 1w76A-5thmA:
39.5		 1w76A-5thmA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 108
GLY A 109
SER A 188
PHE A 276
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 1.09A 1w76B-5thmA:
39.6		 1w76B-5thmA:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 GLY A 186
GLY A 190
GLY A 108
PHE A 473
SER A 212
 None
None
7BZ  A 601 ( 3.6A)
None
None
 1.13A 1wg8A-5thmA:
undetectable		 1wg8A-5thmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 GLY A 186
GLY A 190
GLY A 108
PHE A 473
SER A 212
 None
None
7BZ  A 601 ( 3.6A)
None
None
 1.20A 1wg8B-5thmA:
undetectable		 1wg8B-5thmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 9 GLY A 109
ALA A 110
SER A 188
PHE A 276
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-2.9A)
7BZ  A 601 (-1.4A)
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 1.03A 1y7iA-5thmA:
9.9		 1y7iA-5thmA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		6 / 9 GLY A 108
GLY A 109
SER A 188
ALA A 189
PHE A 113
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.96A 2aceA-5thmA:
9.5		 2aceA-5thmA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 9 GLY A 109
SER A 188
ALA A 189
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 (-3.7A)
None
7BZ  A 601 (-3.8A)
 0.40A 2aceA-5thmA:
9.5		 2aceA-5thmA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 8 VAL A 432
VAL A 457
LEU A 433
HIS A 445
 None
None
None
7BZ  A 601 (-3.8A)
 1.08A 2ddwA-5thmA:
undetectable		 2ddwA-5thmA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 7 GLY A 108
GLY A 109
ALA A 189
PHE A 113
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.97A 2ha4B-5thmA:
39.4		 2ha4B-5thmA:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 GLY A 109
ALA A 189
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-3.7A)
None
7BZ  A 601 (-3.8A)
 0.28A 2ha4B-5thmA:
39.4		 2ha4B-5thmA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 8 HIS A 445
ASP A 319
SER A 214
HIS A 187
 7BZ  A 601 (-3.8A)
None
None
7BZ  A 601 ( 4.8A)
 1.12A 2xadD-5thmA:
undetectable		 2xadD-5thmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 7 GLY A 109
SER A 188
TRP A 221
PHE A 397
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
None
7BZ  A 601 (-3.8A)
 0.50A 3o9mA-5thmA:
40.4		 3o9mA-5thmA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 GLY A 109
SER A 188
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
7BZ  A 601 (-3.8A)
 0.36A 3o9mB-5thmA:
40.4		 3o9mB-5thmA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 HIS A 187
SER A 214
GLU A 318
ASP A 448
 7BZ  A 601 ( 4.8A)
None
None
None
 1.40A 4blvA-5thmA:
undetectable		 4blvA-5thmA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 9 ALA A 115
ALA A  64
GLY A 108
GLY A 109
ASP A  69
 None
None
7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
None
 1.06A 4qwuY-5thmA:
undetectable
4qwuZ-5thmA:
undetectable		 4qwuY-5thmA:
18.41
4qwuZ-5thmA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.23A 4w5oA-5thmA:
undetectable		 4w5oA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.25A 4z4cA-5thmA:
undetectable		 4z4cA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.25A 4z4dA-5thmA:
undetectable		 4z4dA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.23A 4z4eA-5thmA:
3.1		 4z4eA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igiA-5thmA:
undetectable		 5igiA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igjA-5thmA:
undetectable		 5igjA-5thmA:
19.70