SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7BV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.46A 1fohC-5gyzA:
undetectable		 1fohC-5gyzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.46A 1fohD-5gyzA:
undetectable		 1fohD-5gyzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 9 GLY A 355
ILE A 351
GLY A 363
PRO A  11
ILE A 226
 None
7BV  A 500 (-3.1A)
None
None
None
 0.98A 1hpvA-5gyzA:
undetectable		 1hpvA-5gyzA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.48A 1pn0C-5gyzA:
undetectable		 1pn0C-5gyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.48A 1pn0D-5gyzA:
undetectable		 1pn0D-5gyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ALA A 317
GLY A 315
PHE A 292
PHE A 295
 None
7BV  A 500 ( 3.6A)
None
None
 0.97A 2wq5A-5gyzA:
undetectable		 2wq5A-5gyzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 SER A 347
MET A 396
ASP A 422
 7BV  A 500 (-2.3A)
None
AMP  A 501 (-2.7A)
 0.94A 4mm4B-5gyzA:
undetectable		 4mm4B-5gyzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 ARG A 218
ALA A 348
GLY A 315
GLY A 248
PHE A 247
 7BV  A 500 ( 3.0A)
7BV  A 500 (-3.5A)
7BV  A 500 ( 3.6A)
None
7BV  A 500 (-4.0A)
 0.96A 4r29A-5gyzA:
undetectable		 4r29A-5gyzA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.90A 4zdzA-5gyzA:
undetectable		 4zdzA-5gyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.84A 4ze3A-5gyzA:
undetectable		 4ze3A-5gyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.88A 5esmA-5gyzA:
undetectable		 5esmA-5gyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.84A 5hs1A-5gyzA:
undetectable		 5hs1A-5gyzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 VAL A 366
SER A 347
MET A 398
 None
7BV  A 500 (-2.3A)
None
 0.84A 5ikqA-5gyzA:
undetectable		 5ikqA-5gyzA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 GLY A 341
LEU A 287
PHE A 247
THR A 251
TYR A 255
 7BV  A 500 (-3.9A)
None
7BV  A 500 (-4.0A)
7BV  A 500 (-4.4A)
None
 1.12A 5nknA-5gyzA:
undetectable		 5nknA-5gyzA:
10.88