SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7BC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		3 / 3 TRP A 110
PHE A 117
TRP A  26
 7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
7BC  A 202 (-3.6A)
 1.25A 1r15C-5tfzA:
undetectable		 1r15C-5tfzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		3 / 3 TRP A 110
PHE A 117
TRP A  26
 7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
7BC  A 202 (-3.6A)
 1.26A 1r15F-5tfzA:
undetectable		 1r15F-5tfzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		3 / 3 TRP A 110
PHE A 117
TRP A  26
 7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
7BC  A 202 (-3.6A)
 1.26A 1r15G-5tfzA:
undetectable		 1r15G-5tfzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		3 / 3 TRP A 110
PHE A 117
TRP A  26
 7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
7BC  A 202 (-3.6A)
 1.26A 1r15H-5tfzA:
undetectable		 1r15H-5tfzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		5 / 12 LEU A  53
TYR A  21
HIS A  56
PHE A 117
PHE A 112
 7BC  A 202 (-4.9A)
None
NI  A 201 ( 3.8A)
7BC  A 202 ( 4.9A)
None
 1.39A 3r43A-5tfzA:
undetectable		 3r43A-5tfzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		5 / 12 TYR A  21
HIS A  56
TRP A 110
PHE A 117
PHE A 112
 None
NI  A 201 ( 3.8A)
7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
None
 1.24A 3r43A-5tfzA:
undetectable		 3r43A-5tfzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		6 / 12 LEU A  53
TYR A  21
HIS A  56
TRP A 110
PHE A 117
PHE A 112
 7BC  A 202 (-4.9A)
None
NI  A 201 ( 3.8A)
7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
None
 1.40A 3r6iA-5tfzA:
undetectable		 3r6iA-5tfzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		6 / 10 LEU A  53
TYR A  21
HIS A  56
TRP A 110
PHE A 117
PHE A 112
 7BC  A 202 (-4.9A)
None
NI  A 201 ( 3.8A)
7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
None
 1.39A 3r7mA-5tfzA:
undetectable		 3r7mA-5tfzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		5 / 12 TYR A  21
HIS A  56
TRP A 110
PHE A 117
PHE A 112
 None
NI  A 201 ( 3.8A)
7BC  A 202 ( 4.3A)
7BC  A 202 ( 4.9A)
None
 1.31A 3r94A-5tfzA:
undetectable		 3r94A-5tfzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 6 HIS A  58
HIS A  96
TYR A  64
GLU A  62
 NI  A 201 ( 3.3A)
NI  A 201 ( 3.5A)
7BC  A 202 (-4.6A)
7BC  A 202 ( 2.4A)
 0.97A 4pahA-5tfzA:
undetectable		 4pahA-5tfzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		5 / 12 LEU A  53
PHE A 112
HIS A  58
HIS A  96
LEU A  98
 7BC  A 202 (-4.9A)
None
NI  A 201 ( 3.3A)
NI  A 201 ( 3.5A)
None
 1.38A 4r88A-5tfzA:
undetectable		 4r88A-5tfzA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.28A 4tzuB-5tfzA:
undetectable
4tzuC-5tfzA:
undetectable		 4tzuB-5tfzA:
21.15
4tzuC-5tfzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.29A 4tzuB-5tfzA:
undetectable
4tzuC-5tfzA:
undetectable		 4tzuB-5tfzA:
21.15
4tzuC-5tfzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 TYR A 122
ILE A 111
HIS A  56
LEU A  53
 7BC  A 202 (-4.7A)
None
NI  A 201 ( 3.8A)
7BC  A 202 (-4.9A)
 1.22A 4xo7B-5tfzA:
undetectable		 4xo7B-5tfzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 4 HIS A  58
HIS A  96
TYR A  64
GLU A  62
 NI  A 201 ( 3.3A)
NI  A 201 ( 3.5A)
7BC  A 202 (-4.6A)
7BC  A 202 ( 2.4A)
 0.98A 5pahA-5tfzA:
undetectable		 5pahA-5tfzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.28A 5yizG-5tfzA:
undetectable
5yizY-5tfzA:
undetectable		 5yizG-5tfzA:
20.67
5yizY-5tfzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.30A 5yizk-5tfzA:
undetectable
5yizt-5tfzA:
undetectable		 5yizk-5tfzA:
20.67
5yizt-5tfzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.31A 5yj0G-5tfzA:
undetectable
5yj0Y-5tfzA:
undetectable		 5yj0G-5tfzA:
20.67
5yj0Y-5tfzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.31A 5yj0k-5tfzA:
undetectable
5yj0t-5tfzA:
undetectable		 5yj0k-5tfzA:
20.67
5yj0t-5tfzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.32A 5yj0k-5tfzA:
undetectable
5yj0t-5tfzA:
undetectable		 5yj0k-5tfzA:
20.67
5yj0t-5tfzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 8 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.26A 5yj1G-5tfzA:
undetectable
5yj1Y-5tfzA:
undetectable		 5yj1G-5tfzA:
20.51
5yj1Y-5tfzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.33A 5yj1k-5tfzA:
undetectable
5yj1t-5tfzA:
undetectable		 5yj1k-5tfzA:
20.51
5yj1t-5tfzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 8 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.28A 5yj1k-5tfzA:
undetectable
5yj1t-5tfzA:
undetectable		 5yj1k-5tfzA:
20.51
5yj1t-5tfzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 7 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.29A 5yj1G-5tfzA:
undetectable
5yj1Y-5tfzA:
undetectable		 5yj1G-5tfzA:
20.51
5yj1Y-5tfzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK
(Candidatus
Pelagibacter
ubique) 		4 / 6 HIS A  58
HIS A  96
TYR A  64
GLU A  62
 NI  A 201 ( 3.3A)
NI  A 201 ( 3.5A)
7BC  A 202 (-4.6A)
7BC  A 202 ( 2.4A)
 0.96A 6pahA-5tfzA:
undetectable		 6pahA-5tfzA:
18.33