SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7AH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 12 PHE A 168
LEU A  97
ALA A 100
TYR A 345
ILE A 328
 None
None
None
7AH  A1000 (-4.7A)
None
 1.26A 1mx8A-4cgnA:
undetectable		 1mx8A-4cgnA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 GLY A 397
GLN A 216
VAL A 378
SER A 214
 None
None
7AH  A1000 (-4.8A)
None
 1.44A 1rs6B-4cgnA:
undetectable		 1rs6B-4cgnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 GLY A 397
GLN A 216
VAL A 378
SER A 214
 None
None
7AH  A1000 (-4.8A)
None
 1.30A 1zzqB-4cgnA:
undetectable		 1zzqB-4cgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 PHE A  88
ILE A 328
ASN A 337
PHE A  90
 None
None
None
7AH  A1000 (-3.9A)
 1.24A 3octA-4cgnA:
undetectable		 3octA-4cgnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		3 / 3 THR A 331
ASN A  91
SER A 330
 None
None
7AH  A1000 (-3.0A)
 0.77A 4tvtA-4cgnA:
undetectable		 4tvtA-4cgnA:
18.64