SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7AE'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_A_STIA201_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 12 | LEU A 593VAL A 601ALA A 617MET A 641PHE A 673GLY A 677ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 ( 3.7A) | 0.85A | 1iepA-5td2A:29.0 | 1iepA-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_B_STIB202_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593ALA A 617MET A 641PHE A 673ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 1.05A | 1iepB-5td2A:28.9 | 1iepB-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_B_STIB202_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 12 | LEU A 593VAL A 601ALA A 617MET A 641PHE A 673GLY A 677ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 ( 3.7A) | 0.87A | 1iepB-5td2A:28.9 | 1iepB-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_A_STIA600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | VAL A 601ALA A 617MET A 641PHE A 673GLY A 677ALA A 740 | 7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 ( 3.7A) | 0.78A | 2hyyA-5td2A:28.9 | 2hyyA-5td2A:43.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_B_STIB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | VAL A 601ALA A 617MET A 641PHE A 673GLY A 677ALA A 740 | 7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 ( 3.7A) | 0.75A | 2hyyB-5td2A:29.2 | 2hyyB-5td2A:43.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITY_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 12 | LEU A 593GLY A 594VAL A 601ALA A 617LYS A 619MET A 641GLY A 677ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.2A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.1A)None7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.83A | 2ityA-5td2A:24.2 | 2ityA-5td2A:34.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2WGJ_A_VGHA2346_1 (HEPATOCYTE GROWTHFACTOR RECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 9 / 12 | GLY A 594VAL A 601ALA A 617LEU A 671MET A 674GLY A 677MET A 730ALA A 740ASP A 741 | 7AE A1000 ( 4.2A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 (-3.6A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.49A | 2wgjA-5td2A:30.9 | 2wgjA-5td2A:43.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2XP2_A_VGHA9000_1 (TYROSINE-PROTEINKINASE RECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 9 | LEU A 593VAL A 601ALA A 617LEU A 671MET A 674GLY A 677ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.41A | 2xp2A-5td2A:29.4 | 2xp2A-5td2A:37.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3AOX_A_EMHA901_1 (ALK TYROSINE KINASERECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 10 | LEU A 593ALA A 617LYS A 619LEU A 671MET A 674GLY A 677 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)7AE A1000 (-3.1A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A) | 0.47A | 3aoxA-5td2A:11.8 | 3aoxA-5td2A:35.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_A_NILA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | ALA A 617MET A 641GLY A 677PHE A 719HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)NoneNone7AE A1000 ( 3.7A) | 0.75A | 3cs9A-5td2A:29.5 | 3cs9A-5td2A:42.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 5 / 12 | ALA A 617MET A 641GLY A 677HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)None7AE A1000 ( 3.7A) | 0.60A | 3cs9B-5td2A:30.3 | 3cs9B-5td2A:42.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_C_NILC600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | ALA A 617MET A 641PHE A 673PHE A 719HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 (-4.1A)NoneNone7AE A1000 ( 3.7A) | 0.80A | 3cs9C-5td2A:29.5 | 3cs9C-5td2A:42.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | ALA A 617MET A 641GLY A 677PHE A 719HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)NoneNone7AE A1000 ( 3.7A) | 0.66A | 3cs9D-5td2A:22.2 | 3cs9D-5td2A:42.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | ALA A 617MET A 641PHE A 673GLY A 677HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)None7AE A1000 ( 3.7A) | 0.61A | 3cs9D-5td2A:22.2 | 3cs9D-5td2A:42.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MIY_B_B49B2_1 (TYROSINE-PROTEINKINASE ITK/TSK) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 5 / 9 | ALA A 617LYS A 619PHE A 673MET A 674GLY A 677 | 7AE A1000 (-3.3A)7AE A1000 (-3.1A)7AE A1000 (-4.1A)None7AE A1000 ( 3.7A) | 0.55A | 3miyB-5td2A:31.2 | 3miyB-5td2A:38.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MS9_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 12 | LEU A 593VAL A 601ALA A 617MET A 641PHE A 673ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.98A | 3ms9A-5td2A:29.1 | 3ms9A-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593ALA A 617MET A 641PHE A 673ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.99A | 3mssA-5td2A:29.3 | 3mssA-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593VAL A 601ALA A 617MET A 641PHE A 673ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A) | 0.75A | 3mssA-5td2A:29.3 | 3mssA-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_C_STIC1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593ALA A 617MET A 641PHE A 673ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 1.00A | 3mssC-5td2A:29.4 | 3mssC-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_C_STIC1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593VAL A 601ALA A 617MET A 641PHE A 673ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A) | 0.75A | 3mssC-5td2A:29.4 | 3mssC-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_D_STID1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593ALA A 617MET A 641PHE A 673ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 1.00A | 3mssD-5td2A:29.3 | 3mssD-5td2A:41.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_D_STID1_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 12 | LEU A 593ALA A 617MET A 641PHE A 673GLY A 677ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)None7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 ( 3.7A) | 0.84A | 3mssD-5td2A:29.3 | 3mssD-5td2A:41.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_2 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 3 / 3 | LEU A 671MET A 674ASP A 678 | 7AE A1000 (-3.7A)None7AE A1000 ( 4.8A) | 0.63A | 3v5wA-5td2A:10.0 | 3v5wA-5td2A:17.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3WZE_A_BAXA1201_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 12 | LEU A 593VAL A 601ALA A 617LYS A 619PHE A 673GLY A 677LEU A 714HIS A 721 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.1A)7AE A1000 (-4.1A)7AE A1000 ( 3.7A)NoneNone | 0.67A | 3wzeA-5td2A:29.4 | 3wzeA-5td2A:39.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZBF_A_VGHA3000_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 12 | LEU A 593ALA A 617LEU A 671MET A 674GLY A 677ASP A 678THR A 681ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 ( 4.8A)None7AE A1000 (-4.4A) | 0.61A | 3zbfA-5td2A:30.4 | 3zbfA-5td2A:40.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANQ_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 9 | LEU A 593VAL A 601ALA A 617LEU A 671MET A 674GLY A 677ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.52A | 4anqA-5td2A:29.0 | 4anqA-5td2A:34.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANS_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 9 | LEU A 593VAL A 601ALA A 617MET A 674GLY A 677ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.57A | 4ansA-5td2A:28.9 | 4ansA-5td2A:34.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ASD_A_BAXA1500_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 12 | LEU A 593VAL A 601ALA A 617LYS A 619PHE A 673GLY A 677LEU A 714HIS A 721 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.1A)7AE A1000 (-4.1A)7AE A1000 ( 3.7A)NoneNone | 0.72A | 4asdA-5td2A:29.0 | 4asdA-5td2A:36.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IAA_A_RTZA401_1 (SERINE/THREONINE-PROTEIN KINASE PIM-1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 11 | VAL A 601ALA A 617LYS A 619LEU A 671ASP A 678ASP A 741 | 7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.1A)7AE A1000 (-3.7A)7AE A1000 ( 4.8A)7AE A1000 (-4.4A) | 0.75A | 4iaaA-5td2A:20.8 | 4iaaA-5td2A:25.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TWP_A_AXIA601_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 12 | VAL A 601ALA A 617PHE A 673MET A 674GLY A 677ASN A 728ALA A 740ASP A 741 | 7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-4.1A)None7AE A1000 ( 3.7A)7AE A1000 (-4.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.60A | 4twpA-5td2A:29.9 | 4twpA-5td2A:44.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TWP_B_AXIB601_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 9 / 12 | LEU A 593VAL A 601ALA A 617PHE A 673MET A 674GLY A 677ASN A 728ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-4.1A)None7AE A1000 ( 3.7A)7AE A1000 (-4.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.63A | 4twpB-5td2A:16.9 | 4twpB-5td2A:44.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_A_RXTA601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 8 / 11 | LEU A 593VAL A 601ALA A 617MET A 674GLY A 677ASN A 728ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)7AE A1000 (-4.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.54A | 4u5jA-5td2A:21.7 | 4u5jA-5td2A:38.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_B_RXTB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 9 | LEU A 593VAL A 601ALA A 617MET A 674GLY A 677ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.71A | 4u5jB-5td2A:21.5 | 4u5jB-5td2A:38.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 5 / 12 | ALA A 617MET A 641LEU A 714HIS A 721ALA A 740 | 7AE A1000 (-3.3A)NoneNoneNone7AE A1000 ( 3.7A) | 0.71A | 4v01A-5td2A:29.6 | 4v01A-5td2A:41.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_B_0LIB1770_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 5 / 12 | ALA A 617MET A 641LEU A 714HIS A 721ALA A 740 | 7AE A1000 (-3.3A)NoneNoneNone7AE A1000 ( 3.7A) | 0.59A | 4v01B-5td2A:29.9 | 4v01B-5td2A:41.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WA9_A_AXIA9000_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 6 / 11 | LEU A 593ALA A 617MET A 674GLY A 677ASN A 728ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)7AE A1000 (-4.7A)7AE A1000 ( 3.7A) | 0.71A | 4wa9A-5td2A:27.8 | 4wa9A-5td2A:42.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WA9_B_AXIB9000_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 12 | VAL A 601ALA A 617PHE A 673MET A 674GLY A 677ASN A 728ALA A 740 | 7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-4.1A)None7AE A1000 ( 3.7A)7AE A1000 (-4.7A)7AE A1000 ( 3.7A) | 0.61A | 4wa9B-5td2A:29.0 | 4wa9B-5td2A:42.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAA_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 9 | LEU A 593VAL A 601ALA A 617LEU A 671MET A 674GLY A 677ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.50A | 5aaaA-5td2A:12.8 | 5aaaA-5td2A:38.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAB_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 10 | LEU A 593VAL A 601ALA A 617LEU A 671MET A 674GLY A 677ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.51A | 5aabA-5td2A:21.1 | 5aabA-5td2A:38.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAC_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 10 | LEU A 593VAL A 601ALA A 617LEU A 671MET A 674GLY A 677ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 (-3.7A)None7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.38A | 5aacA-5td2A:21.2 | 5aacA-5td2A:37.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AJQ_A_DB8A800_1 (SERINE/THREONINE-PROTEIN KINASE 10) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 7 / 12 | LEU A 593GLY A 594ALA A 617PHE A 673GLY A 677ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.2A)7AE A1000 (-3.3A)7AE A1000 (-4.1A)7AE A1000 ( 3.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 1.04A | 5ajqA-5td2A:17.8 | 5ajqA-5td2A:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5XV7_A_EMHA705_1 (SERINE-ARGININE (SR)PROTEIN KINASE 1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 5 / 12 | LEU A 593GLY A 594VAL A 601ALA A 617ALA A 740 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.2A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)7AE A1000 ( 3.7A) | 0.28A | 5xv7A-5td2A:19.7 | 5xv7A-5td2A:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD4_B_STIB602_1 (TYROSINE-PROTEINKINASE ABL1) |
5td2 | TYROSINE-PROTEINKINASE MER (Homosapiens) | 4 / 6 | LEU A 593PHE A 673MET A 674GLY A 677 | 7AE A1000 ( 3.9A)7AE A1000 (-4.1A)None7AE A1000 ( 3.7A) | 0.60A | 6hd4B-5td2A:28.4 | 6hd4B-5td2A:12.93 |