SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7AE'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 12 LEU A 593
VAL A 601
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
0.85A 1iepA-5td2A:
29.0
1iepA-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
1.05A 1iepB-5td2A:
28.9
1iepB-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 12 LEU A 593
VAL A 601
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
0.87A 1iepB-5td2A:
28.9
1iepB-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 VAL A 601
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
0.78A 2hyyA-5td2A:
28.9
2hyyA-5td2A:
43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 VAL A 601
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
0.75A 2hyyB-5td2A:
29.2
2hyyB-5td2A:
43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 12 LEU A 593
GLY A 594
VAL A 601
ALA A 617
LYS A 619
MET A 641
GLY A 677
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.2A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.83A 2ityA-5td2A:
24.2
2ityA-5td2A:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
9 / 12 GLY A 594
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
MET A 730
ALA A 740
ASP A 741
7AE  A1000 ( 4.2A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-3.6A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.49A 2wgjA-5td2A:
30.9
2wgjA-5td2A:
43.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 9 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.41A 2xp2A-5td2A:
29.4
2xp2A-5td2A:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 10 LEU A 593
ALA A 617
LYS A 619
LEU A 671
MET A 674
GLY A 677
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
0.47A 3aoxA-5td2A:
11.8
3aoxA-5td2A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 ALA A 617
MET A 641
GLY A 677
PHE A 719
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
None
None
7AE  A1000 ( 3.7A)
0.75A 3cs9A-5td2A:
29.5
3cs9A-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
5 / 12 ALA A 617
MET A 641
GLY A 677
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
None
7AE  A1000 ( 3.7A)
0.60A 3cs9B-5td2A:
30.3
3cs9B-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 ALA A 617
MET A 641
PHE A 673
PHE A 719
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
None
None
7AE  A1000 ( 3.7A)
0.80A 3cs9C-5td2A:
29.5
3cs9C-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 ALA A 617
MET A 641
GLY A 677
PHE A 719
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
None
None
7AE  A1000 ( 3.7A)
0.66A 3cs9D-5td2A:
22.2
3cs9D-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 ALA A 617
MET A 641
PHE A 673
GLY A 677
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
None
7AE  A1000 ( 3.7A)
0.61A 3cs9D-5td2A:
22.2
3cs9D-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
5 / 9 ALA A 617
LYS A 619
PHE A 673
MET A 674
GLY A 677
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
0.55A 3miyB-5td2A:
31.2
3miyB-5td2A:
38.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 12 LEU A 593
VAL A 601
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.98A 3ms9A-5td2A:
29.1
3ms9A-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.99A 3mssA-5td2A:
29.3
3mssA-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
VAL A 601
ALA A 617
MET A 641
PHE A 673
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
0.75A 3mssA-5td2A:
29.3
3mssA-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
1.00A 3mssC-5td2A:
29.4
3mssC-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
VAL A 601
ALA A 617
MET A 641
PHE A 673
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
0.75A 3mssC-5td2A:
29.4
3mssC-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
1.00A 3mssD-5td2A:
29.3
3mssD-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 12 LEU A 593
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
0.84A 3mssD-5td2A:
29.3
3mssD-5td2A:
41.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
3 / 3 LEU A 671
MET A 674
ASP A 678
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 4.8A)
0.63A 3v5wA-5td2A:
10.0
3v5wA-5td2A:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 12 LEU A 593
VAL A 601
ALA A 617
LYS A 619
PHE A 673
GLY A 677
LEU A 714
HIS A 721
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
None
None
0.67A 3wzeA-5td2A:
29.4
3wzeA-5td2A:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 12 LEU A 593
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 678
THR A 681
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 ( 4.8A)
None
7AE  A1000 (-4.4A)
0.61A 3zbfA-5td2A:
30.4
3zbfA-5td2A:
40.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 9 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.52A 4anqA-5td2A:
29.0
4anqA-5td2A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 9 LEU A 593
VAL A 601
ALA A 617
MET A 674
GLY A 677
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.57A 4ansA-5td2A:
28.9
4ansA-5td2A:
34.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 12 LEU A 593
VAL A 601
ALA A 617
LYS A 619
PHE A 673
GLY A 677
LEU A 714
HIS A 721
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
None
None
0.72A 4asdA-5td2A:
29.0
4asdA-5td2A:
36.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 11 VAL A 601
ALA A 617
LYS A 619
LEU A 671
ASP A 678
ASP A 741
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-3.7A)
7AE  A1000 ( 4.8A)
7AE  A1000 (-4.4A)
0.75A 4iaaA-5td2A:
20.8
4iaaA-5td2A:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 12 VAL A 601
ALA A 617
PHE A 673
MET A 674
GLY A 677
ASN A 728
ALA A 740
ASP A 741
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.60A 4twpA-5td2A:
29.9
4twpA-5td2A:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
9 / 12 LEU A 593
VAL A 601
ALA A 617
PHE A 673
MET A 674
GLY A 677
ASN A 728
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.63A 4twpB-5td2A:
16.9
4twpB-5td2A:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
8 / 11 LEU A 593
VAL A 601
ALA A 617
MET A 674
GLY A 677
ASN A 728
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.54A 4u5jA-5td2A:
21.7
4u5jA-5td2A:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 9 LEU A 593
VAL A 601
ALA A 617
MET A 674
GLY A 677
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.71A 4u5jB-5td2A:
21.5
4u5jB-5td2A:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
5 / 12 ALA A 617
MET A 641
LEU A 714
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
None
None
7AE  A1000 ( 3.7A)
0.71A 4v01A-5td2A:
29.6
4v01A-5td2A:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
5 / 12 ALA A 617
MET A 641
LEU A 714
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
None
None
7AE  A1000 ( 3.7A)
0.59A 4v01B-5td2A:
29.9
4v01B-5td2A:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
6 / 11 LEU A 593
ALA A 617
MET A 674
GLY A 677
ASN A 728
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
0.71A 4wa9A-5td2A:
27.8
4wa9A-5td2A:
42.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 12 VAL A 601
ALA A 617
PHE A 673
MET A 674
GLY A 677
ASN A 728
ALA A 740
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
0.61A 4wa9B-5td2A:
29.0
4wa9B-5td2A:
42.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 9 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.50A 5aaaA-5td2A:
12.8
5aaaA-5td2A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 10 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.51A 5aabA-5td2A:
21.1
5aabA-5td2A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 10 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
0.38A 5aacA-5td2A:
21.2
5aacA-5td2A:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
7 / 12 LEU A 593
GLY A 594
ALA A 617
PHE A 673
GLY A 677
ALA A 740
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.2A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
1.04A 5ajqA-5td2A:
17.8
5ajqA-5td2A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
5 / 12 LEU A 593
GLY A 594
VAL A 601
ALA A 617
ALA A 740
7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.2A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 ( 3.7A)
0.28A 5xv7A-5td2A:
19.7
5xv7A-5td2A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo
sapiens)
4 / 6 LEU A 593
PHE A 673
MET A 674
GLY A 677
7AE  A1000 ( 3.9A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
0.60A 6hd4B-5td2A:
28.4
6hd4B-5td2A:
12.93