SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7A7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		4 / 7 ASN A 280
HIS A 273
PHE A 296
ILE A 259
 7A7  A 501 ( 4.8A)
None
None
None
 1.26A 1tdnA-5lxdA:
undetectable		 1tdnA-5lxdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 176
LYS A 178
GLU A 193
LEU A 197
LEU A 266
HIS A 273
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
None
None
 0.84A 1uwhB-5lxdA:
20.4		 1uwhB-5lxdA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		4 / 7 ILE A 155
LYS A 178
LEU A 197
ILE A 271
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.5A)
None
None
 0.78A 1uwjA-5lxdA:
7.6		 1uwjA-5lxdA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		7 / 12 ILE A 155
VAL A 163
LYS A 178
PHE A 228
ASN A 280
LEU A 282
ASP A 295
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.56A 2eufB-5lxdA:
30.4		 2eufB-5lxdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		7 / 12 ILE A 155
VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.75A 2y7jA-5lxdA:
26.4		 2y7jA-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		7 / 10 ILE A 155
VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.84A 2y7jB-5lxdA:
22.9		 2y7jB-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 10 VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-3.2A)
 0.72A 2y7jB-5lxdA:
22.9		 2y7jB-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		7 / 10 ILE A 155
VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.80A 2y7jC-5lxdA:
22.8		 2y7jC-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 10 ILE A 155
VAL A 163
ALA A 176
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.89A 2y7jD-5lxdA:
26.2		 2y7jD-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 10 VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.69A 2y7jD-5lxdA:
26.2		 2y7jD-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 163
ALA A 176
GLU A 193
LEU A 197
ILE A 212
HIS A 273
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
None
 0.88A 3gp0A-5lxdA:
25.8		 3gp0A-5lxdA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 156
VAL A 163
ALA A 176
LYS A 178
LEU A 197
ILE A 212
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
None
7A7  A 501 (-4.8A)
 0.77A 3ohtA-5lxdA:
6.5		 3ohtA-5lxdA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 12 GLY A 156
VAL A 163
ALA A 176
LYS A 178
ILE A 212
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
 0.46A 3ohtB-5lxdA:
8.8		 3ohtB-5lxdA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 163
ALA A 176
GLU A 193
LEU A 197
ILE A 212
PHE A 228
LEU A 266
HIS A 273
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
None
 0.79A 3rgfA-5lxdA:
11.9		 3rgfA-5lxdA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 8 LYS A 178
ILE A 212
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.58A 3warA-5lxdA:
28.8		 3warA-5lxdA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 8 VAL A 163
LYS A 178
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.59A 3warA-5lxdA:
28.8		 3warA-5lxdA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 163
ALA A 176
GLU A 193
ILE A 196
ILE A 212
LEU A 282
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
7A7  A 501 (-4.9A)
 0.97A 4bkjB-5lxdA:
20.0		 4bkjB-5lxdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 163
ALA A 176
GLU A 193
ILE A 212
MET A 226
LEU A 282
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
7A7  A 501 (-4.8A)
None
7A7  A 501 (-4.9A)
 0.95A 4bkjB-5lxdA:
20.0		 4bkjB-5lxdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		9 / 12 PHE A 160
VAL A 163
ALA A 176
ILE A 212
ASP A 275
ASN A 280
LEU A 282
ILE A 294
ASP A 295
 7A7  A 501 (-4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.93A 4i41A-5lxdA:
24.6		 4i41A-5lxdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		9 / 12 PHE A 160
VAL A 163
ALA A 176
ILE A 212
ASP A 275
LYS A 277
ASN A 280
ILE A 294
ASP A 295
 7A7  A 501 (-4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
7A7  A 501 ( 4.3A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.96A 4i41A-5lxdA:
24.6		 4i41A-5lxdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 11 VAL A 163
ALA A 176
LYS A 178
LEU A 282
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.9A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.60A 4iaaA-5lxdA:
24.2		 4iaaA-5lxdA:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 8 ILE A 155
VAL A 163
ALA A 176
ASN A 280
LEU A 282
ASP A 295
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.62A 4ogrA-5lxdA:
29.4		 4ogrA-5lxdA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 9 ILE A 155
VAL A 163
ALA A 176
ASN A 280
LEU A 282
ASP A 295
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.64A 4ogrI-5lxdA:
29.2		 4ogrI-5lxdA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 10 ALA A 176
LYS A 178
ILE A 212
LEU A 230
LEU A 282
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
7A7  A 501 (-4.9A)
 0.57A 4rz7A-5lxdA:
23.8		 4rz7A-5lxdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 10 ILE A 155
ALA A 176
LYS A 178
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
None
7A7  A 501 (-4.9A)
 0.74A 4rz7A-5lxdA:
23.8		 4rz7A-5lxdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 176
LYS A 178
LEU A 197
ASP A 295
PHE A 296
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
None
7A7  A 501 (-3.2A)
None
 0.95A 4xv2B-5lxdA:
20.5		 4xv2B-5lxdA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 11 VAL A 306
GLY A 297
ASN A 280
GLU A 192
ILE A 196
 None
None
7A7  A 501 ( 4.8A)
None
None
 1.47A 4zvmA-5lxdA:
undetectable
4zvmB-5lxdA:
undetectable		 4zvmA-5lxdA:
18.47
4zvmB-5lxdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 176
LYS A 178
GLU A 193
LEU A 197
LEU A 266
HIS A 273
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
None
None
 0.92A 5hi2A-5lxdA:
20.7		 5hi2A-5lxdA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 7 GLY A 156
GLY A 158
SER A 159
VAL A 163
LYS A 178
 7A7  A 501 (-3.2A)
None
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
 0.68A 5izjA-5lxdA:
24.8		 5izjA-5lxdA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 7 GLY A 156
GLY A 158
SER A 159
VAL A 163
LYS A 178
 7A7  A 501 (-3.2A)
None
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
 0.63A 5j5xA-5lxdA:
25.1		 5j5xA-5lxdA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 7 GLY A 156
GLY A 158
VAL A 163
LYS A 178
ASP A 295
 7A7  A 501 (-3.2A)
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.2A)
 0.51A 5j5xA-5lxdA:
25.1		 5j5xA-5lxdA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 ILE A 155
GLY A 156
VAL A 163
ALA A 176
PHE A 228
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.9A)
 0.48A 5l2iA-5lxdA:
16.1		 5l2iA-5lxdA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 12 ILE A 155
GLY A 156
VAL A 163
ALA A 176
PHE A 228
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.9A)
 0.86A 5l2tA-5lxdA:
16.3		 5l2tA-5lxdA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 9 ILE A 155
GLY A 156
VAL A 163
ALA A 176
ILE A 212
ASN A 234
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
 0.81A 5lw1B-5lxdA:
20.4		 5lw1B-5lxdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 10 GLY A 156
VAL A 163
ALA A 176
ILE A 212
LEU A 230
ASN A 234
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
None
 0.68A 5lw1E-5lxdA:
22.0		 5lw1E-5lxdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 9 GLY A 156
VAL A 163
ALA A 176
LEU A 230
ASN A 234
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
None
None
 0.74A 5lw1H-5lxdA:
22.3		 5lw1H-5lxdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		4 / 8 ALA A 176
GLU A 193
LEU A 282
ASP A 295
 7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.53A 5owrA-5lxdA:
15.7		 5owrA-5lxdA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 163
ALA A 176
LYS A 178
GLU A 193
LEU A 230
LEU A 282
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.47A 5y80A-5lxdA:
22.9		 5y80A-5lxdA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 8 VAL A 163
LYS A 178
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.46A 5y9mX-5lxdA:
27.6		 5y9mX-5lxdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		5 / 7 VAL A 163
LYS A 178
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.64A 5yf9B-5lxdA:
27.5		 5yf9B-5lxdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 9 VAL A 163
LYS A 178
ILE A 212
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.64A 5yf9X-5lxdA:
27.4		 5yf9X-5lxdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens) 		6 / 7 VAL A 163
LYS A 178
ILE A 212
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.44A 5ywmX-5lxdA:
27.2		 5ywmX-5lxdA:
10.86