SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7A2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 9 GLY A 281
GLY A 665
GLY A 380
GLY A 381
ARG A 379
 7A2  A 901 ( 3.4A)
7A2  A 901 ( 3.4A)
None
None
7A2  A 901 (-2.9A)
 1.13A 1mxdA-5te1A:
2.0		 1mxdA-5te1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 281
GLY A 665
GLY A 380
GLY A 381
ARG A 379
 7A2  A 901 ( 3.4A)
7A2  A 901 ( 3.4A)
None
None
7A2  A 901 (-2.9A)
 1.12A 1mxgA-5te1A:
undetectable		 1mxgA-5te1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 414
LEU A 388
MET A 391
PHE A 354
ALA A 280
 None
None
None
None
7A2  A 901 ( 4.1A)
 0.93A 2jj8C-5te1A:
undetectable		 2jj8C-5te1A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 745
GLY A 664
GLY A 283
THR A 639
VAL A 626
 None
7A2  A 901 (-4.0A)
PO4  A 902 (-3.5A)
None
7A2  A 901 ( 4.3A)
 1.12A 2okcA-5te1A:
4.4		 2okcA-5te1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		3 / 3 GLY A 341
ARG A 379
TYR A 288
 None
7A2  A 901 (-2.9A)
None
 0.81A 2opxA-5te1A:
2.0		 2opxA-5te1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 664
GLU A 718
ALA A 763
ASP A 290
GLY A 746
 7A2  A 901 (-4.0A)
None
None
None
None
 1.42A 3jzjA-5te1A:
undetectable		 3jzjA-5te1A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 12 ARG A 378
ILE A 414
PHE A 354
ALA A 284
ALA A 345
 None
None
None
None
7A2  A 901 (-3.6A)
 1.31A 3ua1A-5te1A:
undetectable		 3ua1A-5te1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 383
GLY A 380
GLY A 381
THR A 353
GLY A 665
 None
None
None
None
7A2  A 901 ( 3.4A)
 0.89A 4dc3B-5te1A:
3.3		 4dc3B-5te1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		4 / 6 ILE A 673
ILE A 344
SER A 343
PHE A 790
 None
None
7A2  A 901 (-3.6A)
None
 0.85A 4m51A-5te1A:
undetectable		 4m51A-5te1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 345
SER A 343
ARG A 379
GLY A 342
GLU A 599
 7A2  A 901 (-3.6A)
7A2  A 901 (-3.6A)
7A2  A 901 (-2.9A)
None
None
 1.14A 4r29B-5te1A:
undetectable		 4r29B-5te1A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 283
ALA A 345
ARG A 379
SER A 343
ALA A 280
 PO4  A 902 (-3.5A)
7A2  A 901 (-3.6A)
7A2  A 901 (-2.9A)
7A2  A 901 (-3.6A)
7A2  A 901 ( 4.1A)
 1.49A 6qgbA-5te1A:
4.2		 6qgbA-5te1A:
22.14