SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '78P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		5 / 7 HIS A 887
GLY A 888
TYR A 919
LEU A 926
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.6A)
78P  A1101 (-3.8A)
 0.43A 1dmaA-5lx6A:
4.8		 1dmaA-5lx6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		5 / 6 HIS A 887
GLY A 888
TYR A 919
ALA A 921
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-3.8A)
 0.64A 1dmaB-5lx6A:
5.3		 1dmaB-5lx6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 8 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.52A 3u9hA-5lx6A:
18.9		 3u9hA-5lx6A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 8 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.54A 3u9hB-5lx6A:
18.7		 3u9hB-5lx6A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		4 / 6 HIS A 887
GLY A 888
TYR A 919
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 (-3.8A)
 0.34A 4ae1A-5lx6A:
6.0		 4ae1A-5lx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		4 / 5 HIS A 887
GLY A 888
TYR A 919
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 (-3.8A)
 0.35A 4ae1B-5lx6A:
4.5		 4ae1B-5lx6A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 8 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.39A 4bjcA-5lx6A:
18.4		 4bjcA-5lx6A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 7 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.52A 4hyfA-5lx6A:
18.9		 4hyfA-5lx6A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 8 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.51A 4hyfB-5lx6A:
19.0		 4hyfB-5lx6A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 8 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.50A 4hyfC-5lx6A:
19.0		 4hyfC-5lx6A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 11 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.53A 4rv6A-5lx6A:
17.9		 4rv6A-5lx6A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		6 / 11 HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.53A 4rv6B-5lx6A:
18.4		 4rv6B-5lx6A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens) 		5 / 9 HIS A 887
ILE A 897
TYR A 919
SER A 927
TYR A 932
 78P  A1101 (-4.0A)
None
78P  A1101 (-3.7A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
 0.84A 5ha9B-5lx6A:
16.5		 5ha9B-5lx6A:
20.23