SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '78M'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 11 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.91A 1c6yA-6ei3A:
undetectable		 1c6yA-6ei3A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 10 MET A 355
LEU A 352
LEU A 349
ALA A 348
LEU A 172
 78M  A 613 (-4.4A)
78M  A 610 ( 3.8A)
78M  A 610 (-4.3A)
78M  A 610 (-3.7A)
78M  A 612 ( 4.3A)
 1.28A 1gwrA-6ei3A:
undetectable		 1gwrA-6ei3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 462
GLU A 368
GLY A 463
HIS A 480
GLY A  50
 78M  A1493 (-3.9A)
None
78M  A1493 (-3.7A)
78M  A1493 (-4.0A)
78M  A1499 ( 4.3A)
 0.95A 1n2xB-4b61A:
undetectable		 1n2xB-4b61A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 6 GLY A 185
ILE A 184
VAL A 166
SER A 180
 None
None
None
78M  A 505 (-4.3A)
 1.05A 1rs7B-4xniA:
undetectable		 1rs7B-4xniA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 10 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.92A 1sdvA-6ei3A:
undetectable		 1sdvA-6ei3A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		3 / 3 VAL A  88
TRP A  90
VAL A  93
 None
78M  A 510 ( 4.2A)
None
 0.95A 2izqA-4xniA:
undetectable
2izqB-4xniA:
undetectable		 2izqA-4xniA:
6.55
2izqB-4xniA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 9 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.92A 2o4pB-6ei3A:
undetectable		 2o4pB-6ei3A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 12 ALA A 186
GLY A 188
HIS A 105
LEU A 181
MET A  36
 None
78M  A 603 ( 4.4A)
None
78M  A 611 ( 4.7A)
None
 1.18A 3bxoB-6ei3A:
undetectable		 3bxoB-6ei3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 9 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.93A 3nujB-6ei3A:
undetectable		 3nujB-6ei3A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 9 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.95A 3nuoB-6ei3A:
undetectable		 3nuoB-6ei3A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 11 VAL A 225
ALA A 228
LEU A 275
GLY A 277
GLY A 280
 None
None
78M  A 614 ( 4.7A)
None
78M  A 614 ( 4.1A)
 1.07A 3zosA-6ei3A:
undetectable
3zosB-6ei3A:
undetectable		 3zosA-6ei3A:
20.97
3zosB-6ei3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 11 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.95A 4njtA-6ei3A:
undetectable		 4njtA-6ei3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 10 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.97A 4njuB-6ei3A:
undetectable		 4njuB-6ei3A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 10 LEU A 173
ALA A 186
GLY A 191
ILE A 192
ILE A 174
 None
None
None
78M  A 603 (-4.3A)
None
 0.97A 4njuD-6ei3A:
undetectable		 4njuD-6ei3A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 7 ASN A 128
TYR A 194
LEU A 190
PHE A 187
 None
None
None
78M  A 505 ( 3.7A)
 1.23A 4yv5A-4xniA:
undetectable		 4yv5A-4xniA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 12 GLY A  72
LEU A 122
GLY A 131
GLY A 104
PHE A  33
 78M  A 606 ( 3.9A)
78M  A 606 ( 4.3A)
None
None
None
 1.11A 5d4uB-6ei3A:
undetectable		 5d4uB-6ei3A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		4 / 8 LEU A 168
LEU A 356
THR A 422
TYR A 418
 78M  A 610 ( 4.6A)
78M  A 613 ( 4.9A)
None
None
 1.08A 5hbsA-6ei3A:
undetectable		 5hbsA-6ei3A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		4 / 7 ILE A 399
GLY A 397
PHE A 423
PHE A 321
 78M  A 605 ( 4.9A)
None
None
None
 0.99A 5hieA-6ei3A:
1.3		 5hieA-6ei3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5ys3 SUCCINATE-ACETATE
PERMEASE
(Citrobacter
koseri) 		5 / 12 TYR A  72
LEU A 103
GLY A 104
VAL A 108
LEU A 138
 ACT  A 203 (-4.0A)
ACT  A 201 ( 4.9A)
78M  A 211 ( 4.0A)
78M  A 211 (-4.5A)
ACT  A 201 (-4.1A)
 1.39A 5jo9A-5ys3A:
undetectable		 5jo9A-5ys3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		4 / 7 THR A 377
LEU A 379
THR A 431
VAL A 314
 None
78M  A 609 (-4.3A)
None
None
 1.14A 5ov9A-6ei3A:
undetectable		 5ov9A-6ei3A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		4 / 8 THR A 377
LEU A 379
THR A 431
VAL A 314
 None
78M  A 609 (-4.3A)
None
None
 1.11A 5ov9B-6ei3A:
undetectable		 5ov9B-6ei3A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN
(Xanthomonas
campestris) 		5 / 12 SER A 326
THR A 315
PHE A 494
PHE A 497
LEU A 490
 None
78M  A 614 ( 4.5A)
None
None
None
 1.21A 6a93A-6ei3A:
undetectable		 6a93A-6ei3A:
20.15