SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '770'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Agrobacterium
fabrum) 		4 / 7 GLU A 108
LEU A 109
VAL A 117
LEU A  96
 SO4  A4770 ( 3.7A)
None
None
None
 1.03A 1hk3A-1zccA:
undetectable		 1hk3A-1zccA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLY A  72
VAL A  28
GLY A  60
GLY A 100
ILE A  29
 None
None
COA  A 760 ( 4.0A)
GOL  A 770 ( 4.3A)
None
 0.69A 1hxbA-2x58A:
undetectable		 1hxbA-2x58A:
8.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 PRO A 565
VAL A 567
TYR A 588
MET A 589
 HAR  A 770 ( 4.5A)
None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
 0.32A 1m8dA-1lzxA:
56.9		 1m8dA-1lzxA:
62.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 VAL A 567
TYR A 588
MET A 589
GLU A 592
 None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
HAR  A 770 ( 2.9A)
 1.33A 1m8dA-1lzxA:
56.9		 1m8dA-1lzxA:
62.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 PRO A 565
VAL A 567
TYR A 588
MET A 589
 HAR  A 770 ( 4.5A)
None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
 0.32A 1m8dB-1lzxA:
57.2		 1m8dB-1lzxA:
62.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 VAL A 567
TYR A 588
MET A 589
GLU A 592
 None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
HAR  A 770 ( 2.9A)
 1.28A 1m8dB-1lzxA:
57.2		 1m8dB-1lzxA:
62.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 PRO A 565
VAL A 567
TYR A 588
MET A 589
 HAR  A 770 ( 4.5A)
None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
 0.21A 1m9jA-1lzxA:
59.0		 1m9jA-1lzxA:
65.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 VAL A 567
TYR A 588
MET A 589
GLU A 592
 None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
HAR  A 770 ( 2.9A)
 1.32A 1m9jA-1lzxA:
59.0		 1m9jA-1lzxA:
65.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 PRO A 565
VAL A 567
TYR A 588
MET A 589
 HAR  A 770 ( 4.5A)
None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
 0.16A 1m9jB-1lzxA:
59.3		 1m9jB-1lzxA:
65.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 VAL A 567
TYR A 588
MET A 589
GLU A 592
 None
HAR  A 770 (-4.7A)
HEM  A 750 ( 4.6A)
HAR  A 770 ( 2.9A)
 1.30A 1m9jB-1lzxA:
59.3		 1m9jB-1lzxA:
65.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 PRO A  71
ALA A 132
GLU A 103
GLU A 123
 None
GOL  A 770 (-3.8A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
 1.31A 1qhyA-2x58A:
undetectable		 1qhyA-2x58A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.58A 1uwhA-2z2wA:
23.6		 1uwhA-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.56A 1uwjA-2z2wA:
22.9		 1uwjA-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ILE A 305
VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.78A 1uwjB-2z2wA:
22.7		 1uwjB-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 12 GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.88A 1v2xA-3nk7A:
18.8		 1v2xA-3nk7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		8 / 12 PHE A 217
GLY A 218
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
 None
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
 0.60A 1v2xA-3nk7A:
18.8		 1v2xA-3nk7A:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 11 GLY A 218
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.85A 1x7pA-3nk7A:
24.1
1x7pB-3nk7A:
24.4		 1x7pA-3nk7A:
30.52
1x7pB-3nk7A:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 10 ASP A 196
GLY A 218
GLY A 223
ILE A 238
MET A 240
LEU A 247
 None
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-4.5A)
 0.51A 1x7pA-3nk7A:
24.1
1x7pB-3nk7A:
24.4		 1x7pA-3nk7A:
30.52
1x7pB-3nk7A:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2j7m HYALURONIDASE
(Clostridium
perfringens) 		4 / 8 SER A 635
ALA A 645
ALA A 760
ARG A 690
 None
None
None
GAL  A1770 ( 2.8A)
 0.90A 2bxmA-2j7mA:
undetectable		 2bxmA-2j7mA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 ILE A 128
GLY A 134
THR A 135
GLU A 103
GLU A 251
 None
None
None
GOL  A 770 (-2.9A)
None
 1.15A 2fn1B-2x58A:
undetectable		 2fn1B-2x58A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  39
ASP A 171
SER A 173
 SEP  A 770 (-3.7A)
SEP  A 770 ( 4.7A)
None
 0.76A 2nxeA-1l7pA:
2.4		 2nxeA-1l7pA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  39
ASP A 171
SER A 173
 SEP  A 770 (-3.7A)
SEP  A 770 ( 4.7A)
None
 0.79A 2nxeB-1l7pA:
2.4		 2nxeB-1l7pA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
ILE A 374
TYR A 378
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.67A 2oiqA-2z2wA:
7.7		 2oiqA-2z2wA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ayg GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 4 SER A1734
GLY A1736
HIS A1527
ASP A 985
 GOL  A2778 (-3.6A)
GOL  A2778 (-3.7A)
None
CA  A2770 (-2.2A)
 1.37A 2oxtC-4aygA:
undetectable		 2oxtC-4aygA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
 0.87A 2pl0A-2z2wA:
22.5		 2pl0A-2z2wA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 9 LEU A 195
GLY A 218
GLY A 223
SER A 237
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-4.5A)
 0.77A 2qmmA-3nk7A:
10.7		 2qmmA-3nk7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 LEU A 195
GLY A 218
GLY A 223
SER A 237
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-4.5A)
 0.85A 2qmmA-3nk7A:
10.7
2qmmB-3nk7A:
10.6		 2qmmA-3nk7A:
21.35
2qmmB-3nk7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 GLY A 306
VAL A 313
ALA A 326
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.63A 2wgjA-2z2wA:
23.3		 2wgjA-2z2wA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 108
HIS A   7
GLU A  34
 SO4  A4770 ( 3.7A)
SO4  A4770 (-4.2A)
None
 0.65A 2x45B-1zccA:
undetectable		 2x45B-1zccA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 108
HIS A   7
GLU A  34
 SO4  A4770 ( 3.7A)
SO4  A4770 (-4.2A)
None
 0.65A 2x45C-1zccA:
undetectable		 2x45C-1zccA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 MET A 411
GLU A 459
ASN A 749
 BGC  A1764 (-3.6A)
GLC  A1769 ( 4.6A)
BGC  A1770 ( 3.0A)
 0.95A 3a27A-2cn3A:
undetectable		 3a27A-2cn3A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 GLY A 218
GLY A 223
ILE A 238
LEU A 247
VAL A 249
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
 0.49A 3dcmX-3nk7A:
14.1		 3dcmX-3nk7A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 11 VAL A 313
ALA A 326
VAL A 360
TYR A 378
CYH A 379
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
 0.50A 3g0eA-2z2wA:
21.6		 3g0eA-2z2wA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 LEU A 195
GLY A 218
ILE A 238
MET A 240
LEU A 247
SER A 252
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.1A)
 0.43A 3gyqA-3nk7A:
30.7
3gyqB-3nk7A:
33.3		 3gyqA-3nk7A:
73.53
3gyqB-3nk7A:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 GLY A 218
ILE A 255
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 (-3.0A)
None
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.18A 3gyqB-3nk7A:
33.3		 3gyqB-3nk7A:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		8 / 11 LEU A 195
GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.39A 3gyqB-3nk7A:
33.3		 3gyqB-3nk7A:
73.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4a01 PROTON
PYROPHOSPHATASE
(Vigna
radiata) 		4 / 4 GLY A 511
ASP A 283
GLY A 503
THR A 185
 None
MG  A1770 ( 2.7A)
K  A1772 ( 4.5A)
None
 1.05A 3k4vC-4a01A:
undetectable		 3k4vC-4a01A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 6 VAL A 313
LYS A 328
VAL A 360
ILE A 374
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.78A 3mssD-2z2wA:
22.6		 3mssD-2z2wA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 ASN A 129
GLU A 220
GLY A 222
SER A 246
ASN A 248
VAL A 249
 SAM  A 770 ( 4.1A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-3.9A)
SAM  A 770 (-4.1A)
SAM  A 770 (-3.7A)
 0.86A 3nk7A-3nk7A:
44.3		 3nk7A-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		8 / 12 ASN A 129
LEU A 195
GLY A 218
GLU A 220
ILE A 255
ASN A 248
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-4.1A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.25A 3nk7A-3nk7A:
44.3		 3nk7A-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		12 / 12 ASN A 129
LEU A 195
THR A 197
GLY A 218
GLU A 220
GLY A 223
ILE A 238
MET A 240
SER A 246
ASN A 248
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.1A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.00A 3nk7A-3nk7A:
44.3		 3nk7A-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		12 / 12 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLU A 220
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.31A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		9 / 12 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLU A 220
ILE A 255
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.37A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 GLU A 220
GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-4.2A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.97A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
GLU A 346
VAL A 360
TYR A 378
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.48A 3oezA-2z2wA:
23.3		 3oezA-2z2wA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ILE A 305
VAL A 313
CYH A 379
PHE A 433
GLY A 465
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.73A 3og7A-2z2wA:
23.4		 3og7A-2z2wA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.78A 3og7A-2z2wA:
23.4		 3og7A-2z2wA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.07A 3r75A-2x58A:
undetectable		 3r75A-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.10A 3r75B-2x58A:
undetectable		 3r75B-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.08A 3r76A-2x58A:
0.0		 3r76A-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.08A 3r76B-2x58A:
0.0		 3r76B-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.31A 3r9sA-2x58A:
19.6		 3r9sA-2x58A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.32A 3r9sC-2x58A:
19.9		 3r9sC-2x58A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.35A 3r9tA-2x58A:
20.3		 3r9tA-2x58A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.37A 3r9tC-2x58A:
20.0		 3r9tC-2x58A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 LEU A 102
LEU A 137
LEU A 138
GLY A 131
LEU A  75
 None
None
None
GOL  A 770 (-3.7A)
None
 1.26A 3uudA-2x58A:
undetectable		 3uudA-2x58A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
GLU A 346
CYH A 379
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
 0.49A 3wzdA-2z2wA:
23.1		 3wzdA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 VAL A 359
VAL A 360
CYH A 379
ILE A 461
 None
770  A 901 ( 4.7A)
770  A 901 (-3.9A)
None
 0.46A 3wzeA-2z2wA:
23.4		 3wzeA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 VAL A 359
VAL A 360
ILE A 461
ASP A 463
 None
770  A 901 ( 4.7A)
None
770  A 901 (-3.8A)
 0.42A 3wzeA-2z2wA:
23.4		 3wzeA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 11 GLY A 306
VAL A 313
ALA A 326
TYR A 378
GLY A 382
SER A 383
 770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
None
 0.65A 4ckiA-2z2wA:
25.6		 4ckiA-2z2wA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4a01 PROTON
PYROPHOSPHATASE
(Vigna
radiata) 		4 / 8 ASP A 269
ASP A 283
GLU A 268
ASP A 731
 MG  A1768 ( 3.9A)
MG  A1770 ( 2.7A)
2PN  A1773 (-3.7A)
2PN  A1773 (-3.9A)
 1.14A 4gkhC-4a01A:
undetectable
4gkhK-4a01A:
0.7		 4gkhC-4a01A:
16.82
4gkhK-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4a01 PROTON
PYROPHOSPHATASE
(Vigna
radiata) 		4 / 8 ASP A 269
ASP A 283
GLU A 268
ASP A 731
 MG  A1768 ( 3.9A)
MG  A1770 ( 2.7A)
2PN  A1773 (-3.7A)
2PN  A1773 (-3.9A)
 1.10A 4gkiE-4a01A:
undetectable
4gkiG-4a01A:
undetectable		 4gkiE-4a01A:
16.82
4gkiG-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
ASP A 386
ASP A 426
LYS A 428
ASN A 431
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
None
None
None
770  A 901 (-3.8A)
 0.60A 4i41A-2z2wA:
27.1		 4i41A-2z2wA:
25.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		6 / 6 ARG A 481
GLU A 592
ARG A 596
ASP A 597
ASP A 600
ARG A 603
 None
HAR  A 770 ( 2.9A)
H4B  A 760 (-3.5A)
HAR  A 770 (-2.8A)
None
None
 0.32A 4kcnA-1lzxA:
63.5		 4kcnA-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		6 / 6 ARG A 481
GLU A 592
ARG A 596
ASP A 597
ASP A 600
ARG A 603
 None
HAR  A 770 ( 2.9A)
H4B  A 760 (-3.5A)
HAR  A 770 (-2.8A)
None
None
 0.32A 4kcnB-1lzxA:
62.2		 4kcnB-1lzxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4a01 PROTON
PYROPHOSPHATASE
(Vigna
radiata) 		4 / 6 ASP A 283
ASP A 507
ALA A 531
ASP A 287
 MG  A1770 ( 2.7A)
MG  A1768 (-2.5A)
None
2PN  A1773 (-3.9A)
 0.97A 4mdaA-4a01A:
undetectable		 4mdaA-4a01A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4a01 PROTON
PYROPHOSPHATASE
(Vigna
radiata) 		4 / 6 ASP A 283
ASP A 507
ALA A 531
ASP A 287
 MG  A1770 ( 2.7A)
MG  A1768 (-2.5A)
None
2PN  A1773 (-3.9A)
 0.93A 4mdbA-4a01A:
undetectable		 4mdbA-4a01A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.78A 4mxoA-2z2wA:
19.2		 4mxoA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.69A 4mxoA-2z2wA:
19.2		 4mxoA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.87A 4mxoB-2z2wA:
19.1		 4mxoB-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
GLU A 346
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.83A 4mxyA-2z2wA:
20.7		 4mxyA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
GLU A 346
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.83A 4mxzA-2z2wA:
20.7		 4mxzA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 8 ILE A 305
VAL A 313
ALA A 326
ASN A 431
ASP A 463
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-3.8A)
 0.58A 4ogrA-2z2wA:
26.6		 4ogrA-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 7 ALA A 326
CYH A 379
ASN A 431
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-3.8A)
 0.26A 4ogrE-2z2wA:
26.2		 4ogrE-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 9 ILE A 305
VAL A 313
ALA A 326
CYH A 379
ASN A 431
ASP A 463
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-3.8A)
 0.62A 4ogrI-2z2wA:
26.3		 4ogrI-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ILE A 305
ALA A 326
LYS A 328
GLU A 346
ILE A 374
TYR A 378
ASP A 463
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.78A 4qmnA-2z2wA:
28.7		 4qmnA-2z2wA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 11 ILE A 305
ALA A 326
GLU A 346
ILE A 374
TYR A 378
ASP A 463
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.68A 4qmsA-2z2wA:
28.6		 4qmsA-2z2wA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 105
GLY A 100
ALA A 120
ILE A 104
VAL A 134
 None
SEP  A 770 (-3.7A)
None
None
None
 1.03A 4r21B-1l7pA:
undetectable		 4r21B-1l7pA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ALA A 326
ILE A 374
SER A 383
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
None
None
770  A 901 (-4.0A)
None
 0.36A 4rzvA-2z2wA:
22.4		 4rzvA-2z2wA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
CYH A 379
SER A 383
PHE A 433
GLY A 462
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.0A)
None
None
 1.20A 4rzvB-2z2wA:
22.4		 4rzvB-2z2wA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 10 VAL A 313
GLU A 346
LEU A 353
VAL A 360
TYR A 378
ILE A 461
 770  A 901 ( 4.7A)
770  A 901 (-3.9A)
None
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
None
 0.75A 4u0iA-2z2wA:
15.6		 4u0iA-2z2wA:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 9 GLY A 218
ILE A 238
MET A 240
SER A 246
VAL A 249
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-3.7A)
 0.64A 4x3mA-3nk7A:
24.9		 4x3mA-3nk7A:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 9 GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
 0.57A 4x3mB-3nk7A:
24.8		 4x3mB-3nk7A:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2v5d O-GLCNACASE NAGJ
(Clostridium
perfringens) 		5 / 12 ILE A 726
TYR A 687
VAL A 763
ASP A 650
THR A 655
 None
None
None
None
CA  A1770 (-3.8A)
 1.29A 4xe0A-2v5dA:
2.0		 4xe0A-2v5dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
770  A 901 (-3.8A)
 0.66A 4xv2A-2z2wA:
23.0		 4xv2A-2z2wA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ALA A 326
CYH A 379
PHE A 433
GLY A 462
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
770  A 901 (-3.8A)
 0.62A 4xv2B-2z2wA:
23.1		 4xv2B-2z2wA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.56A 5cswA-2z2wA:
22.8		 5cswA-2z2wA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.57A 5cswB-2z2wA:
22.7		 5cswB-2z2wA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
ILE A 374
GLY A 382
GLY A 462
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-3.4A)
None
770  A 901 (-3.8A)
 0.83A 5h2uB-2z2wA:
23.8		 5h2uB-2z2wA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
TYR A 378
ASP A 386
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.2A)
None
 0.54A 5hesA-2z2wA:
22.2		 5hesA-2z2wA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
ILE A 374
TYR A 378
ASP A 386
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.2A)
None
None
 0.98A 5hesB-2z2wA:
22.5		 5hesB-2z2wA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 ALA A 326
LYS A 328
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.90A 5hi2A-2z2wA:
23.5		 5hi2A-2z2wA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.67A 5hieA-2z2wA:
4.3		 5hieA-2z2wA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.69A 5hieB-2z2wA:
21.9		 5hieB-2z2wA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.67A 5hieD-2z2wA:
22.2		 5hieD-2z2wA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 ILE A 305
ALA A 326
LYS A 328
ILE A 374
TYR A 378
GLY A 382
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.67A 5i9xA-2z2wA:
24.2		 5i9xA-2z2wA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 137
LEU A 121
VAL A  79
GLY A  76
ALA A 132
 None
None
None
None
GOL  A 770 (-3.8A)
 1.05A 5ikrB-2x58A:
undetectable		 5ikrB-2x58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 7 GLY A 306
GLY A 308
VAL A 313
ASP A 463
 770  A 901 ( 4.6A)
None
770  A 901 ( 4.7A)
770  A 901 (-3.8A)
 0.48A 5j5xA-2z2wA:
19.1		 5j5xA-2z2wA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 12 GLY A 218
GLY A 223
ILE A 238
SER A 246
LEU A 247
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.57A 5l0zA-3nk7A:
23.9		 5l0zA-3nk7A:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1lzx NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 12 ASP A 597
GLU A 592
LEU A 522
GLY A 563
LEU A 564
 HAR  A 770 (-2.8A)
HAR  A 770 ( 2.9A)
None
None
None
 1.33A 5m50E-1lzxA:
undetectable		 5m50E-1lzxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 GLU A 303
ILE A 305
GLY A 306
VAL A 313
ALA A 326
LYS A 328
GLU A 346
TYR A 378
 None
770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
 0.98A 5mafA-2z2wA:
28.0		 5mafA-2z2wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ILE A 305
GLY A 306
VAL A 313
ALA A 326
GLU A 346
TYR A 378
GLY A 382
 770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.60A 5mafA-2z2wA:
28.0		 5mafA-2z2wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 10 VAL A 313
LYS A 328
GLU A 346
ILE A 374
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-3.4A)
 0.70A 5mo4A-2z2wA:
16.4		 5mo4A-2z2wA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 LEU A 102
GLY A 100
GLY A  60
ALA A 105
 None
GOL  A 770 ( 4.3A)
COA  A 760 ( 4.0A)
None
 0.78A 5o96C-2x58A:
undetectable		 5o96C-2x58A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 ALA A 326
GLU A 346
CYH A 379
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-3.8A)
 0.40A 5owrA-2z2wA:
23.1		 5owrA-2z2wA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 LEU A 195
ASP A 196
GLY A 218
GLY A 223
LEU A 247
 SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-4.5A)
 0.63A 5twjD-3nk7A:
8.8		 5twjD-3nk7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 167
LEU A   7
VAL A  94
ALA A 120
GLY A 101
 SEP  A 770 ( 4.4A)
None
None
None
SEP  A 770 ( 4.4A)
 1.11A 5uxdB-1l7pA:
undetectable		 5uxdB-1l7pA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 ALA A 326
GLU A 346
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
770  A 901 (-3.8A)
 0.77A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 ALA A 326
GLU A 346
TYR A 378
CYH A 379
GLY A 382
ASP A 386
PHE A 433
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
None
770  A 901 (-4.0A)
770  A 901 (-3.8A)
 0.57A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		9 / 12 GLU A 303
ILE A 305
ALA A 326
GLU A 346
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.89A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		9 / 12 GLU A 303
ILE A 305
ALA A 326
GLU A 346
TYR A 378
CYH A 379
GLY A 382
ASP A 386
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
None
770  A 901 (-4.0A)
 0.80A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		9 / 12 GLU A 303
ILE A 305
GLY A 306
ALA A 326
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.49A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 4 VAL A 313
LYS A 328
VAL A 360
ASN A 431
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.34A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ALA A 326
LYS A 328
GLU A 346
VAL A 360
GLY A 382
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
None
 0.94A 5vcvA-2z2wA:
32.2		 5vcvA-2z2wA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
CYH A 379
PHE A 433
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
 0.56A 5vcyA-2z2wA:
31.8		 5vcyA-2z2wA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
GLY A 382
PHE A 433
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.93A 5vcyA-2z2wA:
31.8		 5vcyA-2z2wA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.12A 5vooA-2x58A:
undetectable		 5vooA-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.14A 5vooB-2x58A:
undetectable		 5vooB-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.10A 5vooC-2x58A:
undetectable		 5vooC-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.16A 5vooD-2x58A:
undetectable		 5vooD-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 LEU A 195
GLY A 218
GLY A 223
SER A 237
ILE A 238
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-3.8A)
SAM  A 770 (-4.5A)
 1.17A 5zhmB-3nk7A:
7.4		 5zhmB-3nk7A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Agrobacterium
fabrum) 		4 / 6 TYR A 106
GLU A 108
ASP A  36
GLU A  16
 None
SO4  A4770 ( 3.7A)
SO4  A4770 ( 4.1A)
None
 1.48A 6mn5A-1zccA:
undetectable		 6mn5A-1zccA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 PRO A  71
GLY A  99
GLY A 101
VAL A  96
ALA A 132
 None
COA  A 760 ( 4.0A)
None
COA  A 760 ( 4.6A)
GOL  A 770 (-3.8A)
 1.08A 6nj9K-2x58A:
2.2		 6nj9K-2x58A:
20.49