SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '75D'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
THR A  60
PHE A  70
 None
None
75D  A 201 ( 4.1A)
None
None
 1.27A 1mx8A-4nnsA:
16.6		 1mx8A-4nnsA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ARG A 126
TYR A 128
 None
None
75D  A 201 (-2.5A)
None
75D  A 201 (-3.9A)
None
 1.24A 2qm9A-4nnsA:
26.5		 2qm9A-4nnsA:
81.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
VAL A  25
ALA A  33
SER A  53
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
CYH A 117
ARG A 126
TYR A 128
 None
None
75D  A 201 ( 4.1A)
75D  A 201 (-2.5A)
75D  A 201 ( 4.7A)
None
75D  A 201 (-3.6A)
75D  A 201 (-4.1A)
75D  A 201 (-4.7A)
75D  A 201 (-3.5A)
75D  A 201 (-3.9A)
None
 0.43A 2qm9A-4nnsA:
26.5		 2qm9A-4nnsA:
81.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
75D  A 201 (-3.6A)
75D  A 201 (-4.4A)
75D  A 201 ( 4.4A)
 0.30A 2qm9A-4nnsA:
26.5		 2qm9A-4nnsA:
81.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  53
SER A  55
THR A  60
ALA A  75
ARG A  78
ILE A 104
CYH A 117
ARG A 126
TYR A 128
 None
None
None
75D  A 201 (-2.5A)
75D  A 201 ( 4.7A)
None
75D  A 201 (-3.6A)
75D  A 201 (-4.7A)
75D  A 201 ( 4.4A)
75D  A 201 (-3.5A)
75D  A 201 (-3.9A)
None
 0.38A 2qm9B-4nnsA:
26.6		 2qm9B-4nnsA:
81.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ARG A 126
TYR A 128
 None
None
75D  A 201 (-2.5A)
None
75D  A 201 (-3.9A)
None
 1.22A 2qm9B-4nnsA:
26.6		 2qm9B-4nnsA:
81.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 75D  A 201 (-3.6A)
75D  A 201 (-4.4A)
75D  A 201 (-4.1A)
75D  A 201 ( 4.6A)
 0.26A 2qm9B-4nnsA:
26.6		 2qm9B-4nnsA:
81.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 ARG A 106
ASP A  18
GLY A 121
THR A 102
 75D  A 201 ( 4.6A)
None
None
None
 1.04A 3k4vB-4nnsA:
undetectable		 3k4vB-4nnsA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 None
75D  A 201 (-3.6A)
None
75D  A 201 (-4.4A)
75D  A 201 (-4.1A)
75D  A 201 (-4.7A)
75D  A 201 ( 4.4A)
75D  A 201 ( 4.6A)
None
75D  A 201 (-3.5A)
75D  A 201 (-3.9A)
None
 0.39A 3p6gA-4nnsA:
27.7		 3p6gA-4nnsA:
90.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 None
None
75D  A 201 (-4.4A)
75D  A 201 (-3.9A)
None
 1.25A 3p6gA-4nnsA:
27.7		 3p6gA-4nnsA:
90.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 7 PHE A  16
MET A  20
ASP A  76
ILE A 104
VAL A 115
ARG A 126
TYR A 128
 None
75D  A 201 (-3.6A)
75D  A 201 (-4.1A)
75D  A 201 ( 4.4A)
None
75D  A 201 (-3.9A)
None
 0.25A 3p6hA-4nnsA:
27.5		 3p6hA-4nnsA:
90.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 None
None
75D  A 201 ( 4.1A)
None
75D  A 201 ( 4.7A)
 0.79A 5h8tA-4nnsA:
20.1		 5h8tA-4nnsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 None
None
None
75D  A 201 ( 4.1A)
None
75D  A 201 ( 4.7A)
 0.89A 5hbsA-4nnsA:
19.8		 5hbsA-4nnsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
75D  A 201 ( 4.1A)
75D  A 201 (-4.4A)
None
75D  A 201 ( 4.7A)
 0.93A 5hbsA-4nnsA:
19.8		 5hbsA-4nnsA:
31.82