SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '74W'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q63_A_1UNA1001_2 (PROTEASE RETROPEPSIN)	2yof	THYMIDYLATE KINASE (Plasmodium falciparum)	3 / 3	ARG A 99 ASN A 113 THR A 158	74W A 211 (-4.0A) None None	0.67A	2q63A-2yofA: undetectable	2q63A-2yofA: 14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APV_B_TP0B190_1 (ALPHA-1-ACID GLYCOPROTEIN 2)	2yof	THYMIDYLATE KINASE (Plasmodium falciparum)	5 / 12	LEU A 59 GLU A 151 ARG A 47 SER A 103 TYR A 107	74W A 211 (-4.6A) 74W A 211 (-3.2A) 74W A 211 (-4.6A) 74W A 211 ( 4.4A) 74W A 211 (-3.5A)	1.41A	3apvB-2yofA: undetectable	3apvB-2yofA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GLM_A_ACTA613_0 (GLYCOSIDE HYDROLASE FAMILY 43)	2yof	THYMIDYLATE KINASE (Plasmodium falciparum)	3 / 3	ASP A 17 SER A 103 TYR A 107	74W A 211 (-2.6A) 74W A 211 ( 4.4A) 74W A 211 (-3.5A)	0.83A	5glmA-2yofA: undetectable	5glmA-2yofA: 17.87