SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '746'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 137
SER A 183
SER A 185
THR A 187
 5AD  A1746 ( 3.9A)
None
EDO  A1754 (-3.2A)
None
 0.69A 1dvxA-2xijA:
undetectable		 1dvxA-2xijA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.63A 1iepA-4y93A:
30.8		 1iepA-4y93A:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		4 / 8 LEU A 486
VAL A 529
CYH A 527
GLY A 480
 None
None
None
746  A 702 (-3.6A)
 0.96A 1jlfA-4y93A:
2.2
1jlfB-4y93A:
undetectable		 1jlfA-4y93A:
22.91
1jlfB-4y93A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.71A 1m17A-4y93A:
29.4		 1m17A-4y93A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
ALA A 428
LYS A 430
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.58A 1m17A-4y93A:
29.4		 1m17A-4y93A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.71A 1muoA-4y93A:
11.6		 1muoA-4y93A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
 0.74A 1opjA-4y93A:
30.3		 1opjA-4y93A:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.76A 1t46A-4y93A:
30.4		 1t46A-4y93A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
 0.48A 1uwjA-4y93A:
11.5		 1uwjA-4y93A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
 0.47A 1uwjB-4y93A:
11.5		 1uwjB-4y93A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 9 LEU A 408
VAL A 416
ALA A 428
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.44A 1xbbA-4y93A:
30.8		 1xbbA-4y93A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 ALA A 428
GLY A 480
CYH A 481
LEU A 483
LEU A 528
ASP A 539
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.6A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.83A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 ALA A 428
THR A 474
GLY A 480
CYH A 481
LEU A 483
LEU A 528
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
None
746  A 702 (-4.4A)
None
 0.86A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 746  A 702 (-3.6A)
None
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.73A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
PHE A 540
 746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
None
None
746  A 702 (-4.4A)
None
 0.58A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 11 GLY A 409
GLY A 411
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 ( 3.5A)
746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.45A 2evaA-4y93A:
27.1		 2evaA-4y93A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.77A 2gqgA-4y93A:
31.6		 2gqgA-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.53A 2gqgA-4y93A:
31.6		 2gqgA-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.42A 2gqgB-4y93A:
31.8		 2gqgB-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.64A 2oiqA-4y93A:
30.9		 2oiqA-4y93A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 4 SER A 444
GLY A 441
HIS A 448
ASP A 489
 None
GOL  A1746 ( 3.1A)
None
NA  A1731 (-3.2A)
 1.32A 2oxtC-4c1oA:
undetectable		 2oxtC-4c1oA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5g56 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 170
GLU A 171
HIS A 253
TYR A 255
GLU A 279
 None
MPD  A1746 (-2.7A)
None
MPD  A1746 (-3.8A)
None
 0.27A 2v3dA-5g56A:
14.5		 2v3dA-5g56A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 GLY A 409
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
 0.77A 2wgjA-4y93A:
32.1		 2wgjA-4y93A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.34A 2xp2A-4y93A:
31.4		 2xp2A-4y93A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 ALA A 428
LYS A 430
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.68A 2y6oA-4y93A:
31.6		 2y6oA-4y93A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.50A 2zvaA-4y93A:
32.8		 2zvaA-4y93A:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 10 LEU A 408
ALA A 428
LYS A 430
VAL A 458
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.49A 3aoxA-4y93A:
27.4		 3aoxA-4y93A:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 VAL A 416
ALA A 428
MET A 449
LEU A 460
THR A 474
GLY A 480
LEU A 528
ASP A 539
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.75A 3bbtB-4y93A:
31.5		 3bbtB-4y93A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 VAL A 416
ALA A 428
MET A 449
THR A 474
GLY A 480
LEU A 528
ASP A 539
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.79A 3bbtD-4y93A:
31.5		 3bbtD-4y93A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
GLY A 409
ALA A 428
LYS A 430
VAL A 458
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.79A 3c7qA-4y93A:
29.0		 3c7qA-4y93A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 10 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
None
None
 0.91A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 10 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.50A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
LEU A 528
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
 0.59A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
LEU A 528
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
 0.61A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
 0.50A 3cs9B-4y93A:
30.8		 3cs9B-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
VAL A 416
VAL A 458
ILE A 472
LEU A 528
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
746  A 702 (-4.4A)
None
 0.74A 3cs9B-4y93A:
30.8		 3cs9B-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 ALA A 428
LEU A 457
THR A 474
PHE A 517
HIS A 519
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
None
None
 0.72A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 9 LEU A 408
VAL A 416
ILE A 472
MET A 477
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.68A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 9 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
None
None
 0.93A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 9 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.58A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
 0.49A 3cs9D-4y93A:
30.4		 3cs9D-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
 0.49A 3cs9D-4y93A:
30.4		 3cs9D-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 11 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.67A 3g0eA-4y93A:
28.9		 3g0eA-4y93A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 11 LEU A 408
VAL A 416
ALA A 428
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.64A 3g0fA-4y93A:
29.2		 3g0fA-4y93A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 10 LEU A 408
VAL A 416
ALA A 428
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.54A 3g0fB-4y93A:
29.7		 3g0fB-4y93A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.44A 3g5dA-4y93A:
31.0		 3g5dA-4y93A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.65A 3g5dB-4y93A:
31.2		 3g5dB-4y93A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
 0.63A 3gvuA-4y93A:
31.5		 3gvuA-4y93A:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		10 / 12 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.64A 3k54A-4y93A:
35.3		 3k54A-4y93A:
60.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
GLY A 409
GLY A 411
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.70A 3lxnA-4y93A:
28.3		 3lxnA-4y93A:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 11 ALA A 428
LYS A 430
VAL A 458
MET A 477
GLY A 480
LEU A 528
SER A 538
ASP A 539
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
746  A 702 (-3.7A)
 0.65A 3miyA-4y93A:
33.1		 3miyA-4y93A:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
SER A 538
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.64A 3miyB-4y93A:
33.2		 3miyB-4y93A:
35.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.57A 3ms9B-4y93A:
30.8		 3ms9B-4y93A:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.64A 3mssB-4y93A:
31.0		 3mssB-4y93A:
29.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		10 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
CA  A 703 ( 4.5A)
746  A 702 (-4.4A)
 0.97A 3octA-4y93A:
33.6		 3octA-4y93A:
57.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.75A 3oezA-4y93A:
30.8		 3oezA-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 VAL A 416
ALA A 428
LYS A 430
THR A 474
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
 0.69A 3og7A-4y93A:
28.9		 3og7A-4y93A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 GLY A 409
VAL A 416
ALA A 428
THR A 474
ASP A 539
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
 0.53A 3ohtB-4y93A:
5.3		 3ohtB-4y93A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 ALA A 428
LEU A 457
VAL A 458
THR A 474
GLY A 480
HIS A 519
 746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
 0.55A 3oxzA-4y93A:
30.7		 3oxzA-4y93A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 9 LEU A 408
ILE A 472
MET A 477
LEU A 528
VAL A 537
 746  A 702 (-3.8A)
None
None
746  A 702 (-4.4A)
None
 0.61A 3oxzA-4y93A:
30.6		 3oxzA-4y93A:
29.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
 0.68A 3pyyB-4y93A:
30.4		 3pyyB-4y93A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.72A 3qlgA-4y93A:
31.4		 3qlgA-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.51A 3qlgA-4y93A:
31.4		 3qlgA-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.61A 3qlgB-4y93A:
31.2		 3qlgB-4y93A:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.41A 3sxrA-4y93A:
32.9		 3sxrA-4y93A:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.45A 3sxrB-4y93A:
32.4		 3sxrB-4y93A:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
ALA A 428
LYS A 430
VAL A 458
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.73A 3ue4A-4y93A:
31.4		 3ue4A-4y93A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.49A 3ue4A-4y93A:
31.4		 3ue4A-4y93A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.52A 3ue4B-4y93A:
31.2		 3ue4B-4y93A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
ALA A 428
LYS A 430
THR A 474
LEU A 512
HIS A 519
ARG A 520
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
None
None
746  A 702 (-4.4A)
 0.84A 3zosA-4y93A:
29.4		 3zosA-4y93A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 ALA A 428
LYS A 430
THR A 474
LEU A 512
HIS A 519
ARG A 520
LEU A 528
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
None
None
746  A 702 (-4.4A)
 0.77A 3zosB-4y93A:
29.4		 3zosB-4y93A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.70A 4ag8A-4y93A:
30.4		 4ag8A-4y93A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 11 LEU A 408
ALA A 428
LYS A 430
VAL A 458
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.71A 4agdA-4y93A:
29.2		 4agdA-4y93A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.28A 4anqA-4y93A:
31.5		 4anqA-4y93A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.31A 4ansA-4y93A:
31.4		 4ansA-4y93A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 10 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.49A 4ckjA-4y93A:
30.8		 4ckjA-4y93A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.89A 4hjoA-4y93A:
32.4		 4hjoA-4y93A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
MET A 477
GLY A 480
CYH A 481
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.74A 4hjoA-4y93A:
32.4		 4hjoA-4y93A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 10 ALA A 428
VAL A 458
GLY A 480
LEU A 528
SER A 538
ASP A 539
 746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
746  A 702 (-3.7A)
 0.86A 4ks8A-4y93A:
24.7		 4ks8A-4y93A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
 0.46A 4mxoA-4y93A:
31.1		 4mxoA-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.47A 4mxoB-4y93A:
31.1		 4mxoB-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.60A 4mxxA-4y93A:
31.1		 4mxxA-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		10 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.73A 4mxxB-4y93A:
31.0		 4mxxB-4y93A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.51A 4mxyA-4y93A:
31.7		 4mxyA-4y93A:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.41A 4mxyB-4y93A:
31.3		 4mxyB-4y93A:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.51A 4mxzA-4y93A:
31.7		 4mxzA-4y93A:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.41A 4mxzB-4y93A:
31.3		 4mxzB-4y93A:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
LYS A 430
VAL A 458
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.91A 4otwA-4y93A:
31.1		 4otwA-4y93A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.66A 4otwA-4y93A:
31.1		 4otwA-4y93A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 ALA A 428
LYS A 430
ILE A 472
THR A 474
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
None
 0.58A 4rzvA-4y93A:
11.3		 4rzvA-4y93A:
23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.72A 4twpA-4y93A:
31.1		 4twpA-4y93A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.74A 4twpB-4y93A:
31.3		 4twpB-4y93A:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 ALA A 428
LYS A 430
THR A 474
GLY A 480
HIS A 519
LEU A 528
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
 0.58A 4u0iA-4y93A:
30.3		 4u0iA-4y93A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 11 LEU A 408
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.32A 4u5jA-4y93A:
32.2		 4u5jA-4y93A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 9 LEU A 408
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.29A 4u5jB-4y93A:
32.2		 4u5jB-4y93A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 LEU A 408
ALA A 428
LEU A 512
HIS A 519
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
 0.56A 4uxqA-4y93A:
31.0		 4uxqA-4y93A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
VAL A 416
LYS A 430
TYR A 476
ARG A 520
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
746  A 702 (-4.4A)
 1.06A 4v01B-4y93A:
30.6		 4v01B-4y93A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 11 LEU A 408
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.57A 4wa9A-4y93A:
28.6		 4wa9A-4y93A:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 VAL A 416
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.56A 4wa9B-4y93A:
30.8		 4wa9B-4y93A:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		4 / 8 LEU A 408
ALA A 428
LEU A 528
SER A 538
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.70A 4wboB-4y93A:
21.3		 4wboB-4y93A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		4 / 6 LEU A 408
ALA A 428
MET A 477
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
 0.47A 4wboC-4y93A:
21.5		 4wboC-4y93A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.74A 4xeyA-4y93A:
31.4		 4xeyA-4y93A:
36.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.48A 4xeyA-4y93A:
31.4		 4xeyA-4y93A:
36.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.46A 4xeyB-4y93A:
30.7		 4xeyB-4y93A:
36.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
ALA A 428
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.42A 4xliA-4y93A:
31.7		 4xliA-4y93A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.60A 4xliB-4y93A:
31.8		 4xliB-4y93A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.42A 4xliB-4y93A:
31.8		 4xliB-4y93A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.36A 5aaaA-4y93A:
31.9		 5aaaA-4y93A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 10 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.77A 5aabA-4y93A:
31.8		 5aabA-4y93A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 10 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.80A 5aacA-4y93A:
31.7		 5aacA-4y93A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.58A 5h2uA-4y93A:
34.7		 5h2uA-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		3 / 3 ILE A 472
MET A 477
ASP A 539
 None
None
746  A 702 (-3.7A)
 0.67A 5h2uA-4y93A:
34.7		 5h2uA-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
ALA A 428
ILE A 472
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.65A 5h2uC-4y93A:
35.0		 5h2uC-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
ALA A 428
THR A 474
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.71A 5h2uC-4y93A:
35.0		 5h2uC-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
VAL A 416
ALA A 428
ILE A 472
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.61A 5h2uD-4y93A:
34.9		 5h2uD-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.54A 5h2uD-4y93A:
34.9		 5h2uD-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
 0.73A 5hesA-4y93A:
14.5		 5hesA-4y93A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
TYR A 476
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
 0.67A 5hesB-4y93A:
27.6		 5hesB-4y93A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
 746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
 0.31A 5hieA-4y93A:
27.8		 5hieA-4y93A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
 746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
 0.32A 5hieB-4y93A:
27.8		 5hieB-4y93A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 GLY A 409
GLY A 411
VAL A 416
ALA A 428
THR A 474
 746  A 702 ( 3.5A)
746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
 0.43A 5hieC-4y93A:
27.6		 5hieC-4y93A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
 746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
 0.30A 5hieD-4y93A:
27.3		 5hieD-4y93A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
CA  A 703 ( 4.5A)
746  A 702 (-4.4A)
 0.82A 5i9xA-4y93A:
31.4		 5i9xA-4y93A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 ALA A 428
LYS A 430
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
SER A 538
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
CA  A 703 ( 4.5A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.93A 5i9yA-4y93A:
31.1		 5i9yA-4y93A:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 10 LEU A 408
VAL A 416
ILE A 472
MET A 477
GLY A 480
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
746  A 702 (-3.6A)
 0.47A 5mo4A-4y93A:
26.6		 5mo4A-4y93A:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 ALA A 428
LEU A 457
VAL A 458
HIS A 519
LEU A 528
 746  A 702 (-2.4A)
None
None
None
746  A 702 (-4.4A)
 0.78A 5mo4A-4y93A:
26.6		 5mo4A-4y93A:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 10 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.69A 5n3hA-4y93A:
21.9		 5n3hA-4y93A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		9 / 12 GLY A 411
VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
LEU A 528
SER A 538
PHE A 540
 746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
None
 0.71A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
LEU A 528
SER A 538
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
None
 0.73A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		10 / 12 VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
None
 0.48A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 5 LEU A 408
TYR A 476
MET A 477
CYH A 481
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-4.4A)
None
None
746  A 702 (-3.7A)
 0.67A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 LEU A 408
GLY A 409
VAL A 416
ALA A 428
CYH A 481
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.71A 5yu9A-4y93A:
30.2		 5yu9A-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 GLY A 409
VAL A 416
ALA A 428
CYH A 481
LEU A 528
ASP A 539
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.65A 5yu9B-4y93A:
30.7		 5yu9B-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 VAL A 416
ALA A 428
MET A 449
CYH A 481
LEU A 528
ASP A 539
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.86A 5yu9B-4y93A:
30.7		 5yu9B-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		5 / 12 VAL A 416
ALA A 428
GLY A 480
CYH A 481
ASP A 539
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.6A)
None
746  A 702 (-3.7A)
 0.51A 5yu9C-4y93A:
30.3		 5yu9C-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		6 / 12 VAL A 416
ALA A 428
GLY A 480
CYH A 481
LEU A 528
ASP A 539
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.57A 5yu9D-4y93A:
30.6		 5yu9D-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 VAL A 416
ALA A 428
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.35A 6bsdA-4y93A:
29.9		 6bsdA-4y93A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		8 / 12 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.62A 6fnmA-4y93A:
31.9		 6fnmA-4y93A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE
(Bos
taurus) 		7 / 12 VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
SER A 538
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.78A 6fnmA-4y93A:
31.9		 6fnmA-4y93A:
25.75