SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '735'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 8 CYH E 464
ASP E 443
CYH E 441
GLY E 445
 ZN  E 735 (-2.2A)
None
ZN  E 735 (-2.4A)
None
 0.99A 1ekjA-3lvrE:
undetectable
1ekjB-3lvrE:
2.6		 1ekjA-3lvrE:
17.14
1ekjB-3lvrE:
17.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.42A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.54A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
SER A 280
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.80A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 ILE A 272
PHE A 273
CYH A 276
SER A 280
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 ( 4.2A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.67A 1fm6X-2p54A:
36.9		 1fm6X-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 TYR A 464
LEU A 287
LEU A 460
SER A 280
 735  A 469 (-4.6A)
None
735  A 469 (-4.3A)
735  A 469 (-2.8A)
 1.07A 1i7zA-2p54A:
undetectable		 1i7zA-2p54A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 10 LEU A 321
ALA A 362
ILE A 354
HIS A 440
LEU A 436
 735  A 469 ( 4.3A)
None
735  A 469 (-3.7A)
735  A 469 (-4.0A)
None
 1.28A 1pcgA-2p54A:
21.3		 1pcgA-2p54A:
24.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.45A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.69A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.93A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 276
GLN A 277
LEU A 321
MET A 355
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.6A)
 0.98A 2prgA-2p54A:
37.3		 2prgA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
CYH A 276
GLN A 277
SER A 280
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 (-2.8A)
735  A 469 (-4.6A)
 0.99A 2prgA-2p54A:
37.3		 2prgA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 276
LEU A 321
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.83A 2prgA-2p54A:
37.3		 2prgA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
CYH A 276
SER A 280
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.97A 2prgA-2p54A:
37.3		 2prgA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.81A 2prgB-2p54A:
35.1		 2prgB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.91A 2prgB-2p54A:
35.1		 2prgB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 CYH A 276
ILE A 339
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.1A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.42A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 CYH A 276
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.91A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 LEU A 321
ILE A 339
HIS A 440
LEU A 460
TYR A 464
 735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.04A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
CYH A 276
ILE A 339
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 ( 4.1A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.31A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
CYH A 276
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.97A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
LEU A 321
ILE A 339
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.47A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.70A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.63A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 LEU A 247
ILE A 272
GLN A 277
ILE A 317
 None
735  A 469 ( 4.2A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
 0.49A 2xkwA-2p54A:
37.1		 2xkwA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 241
GLU A 251
SER A 280
LEU A 321
MET A 355
 735  A 469 (-4.7A)
None
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.59A 2xkwB-2p54A:
34.0		 2xkwB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 6 LEU A 247
ARG A 271
ILE A 272
ILE A 317
MET A 320
 None
None
735  A 469 ( 4.2A)
735  A 469 ( 4.8A)
None
 0.84A 2xkwB-2p54A:
34.0		 2xkwB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 10 GLU A 251
ARG A 271
ILE A 272
LEU A 321
MET A 355
 None
None
735  A 469 ( 4.2A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.93A 3adsA-2p54A:
37.1		 3adsA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
CYH A 276
LEU A 321
LEU A 344
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.87A 3adsA-2p54A:
37.1		 3adsA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
SER A 280
LEU A 321
LEU A 344
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.64A 3adsA-2p54A:
37.1		 3adsA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 6 ILE A 272
ILE A 317
LEU A 347
PHE A 351
MET A 355
 735  A 469 ( 4.2A)
735  A 469 ( 4.8A)
None
None
735  A 469 (-2.9A)
 0.38A 3adsA-2p54A:
37.1		 3adsA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 272
SER A 280
ILE A 317
LEU A 321
MET A 355
 735  A 469 ( 4.2A)
735  A 469 (-2.8A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.51A 3adsB-2p54A:
33.9		 3adsB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
CYH A 276
GLN A 277
LEU A 321
LEU A 344
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.89A 3adxA-2p54A:
37.2		 3adxA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
GLN A 277
SER A 280
LEU A 321
LEU A 344
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-4.4A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.66A 3adxA-2p54A:
37.2		 3adxA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 7 ILE A 272
ILE A 317
LEU A 347
PHE A 351
MET A 355
LYS A 358
 735  A 469 ( 4.2A)
735  A 469 ( 4.8A)
None
None
735  A 469 (-2.9A)
None
 0.40A 3adxA-2p54A:
37.2		 3adxA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
 0.99A 3cs8A-2p54A:
37.5		 3cs8A-2p54A:
61.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 SER A 280
ILE A 317
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-2.8A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.67A 3cs8A-2p54A:
37.5		 3cs8A-2p54A:
61.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.91A 3cs8A-2p54A:
37.5		 3cs8A-2p54A:
61.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 SER A 280
LEU A 321
MET A 355
LYS A 358
HIS A 440
TYR A 464
 735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
None
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.98A 3cs8A-2p54A:
37.5		 3cs8A-2p54A:
61.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.92A 3dzyD-2p54A:
34.7		 3dzyD-2p54A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 347
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
None
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.42A 3dzyD-2p54A:
34.7		 3dzyD-2p54A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
HIS A 440
VAL A 444
TYR A 464
 735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.67A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 CYH A 275
CYH A 276
TYR A 314
MET A 330
ILE A 339
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.87A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 SER A 280
TYR A 314
MET A 325
ILE A 354
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-2.8A)
735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 1.24A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 TYR A 314
MET A 325
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 1.11A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 255
CYH A 275
CYH A 276
ILE A 354
TYR A 314
 735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.7A)
735  A 469 (-3.9A)
 1.33A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 VAL A 255
CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
VAL A 444
TYR A 464
 735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.78A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 7 LEU A 247
GLN A 277
LEU A 321
VAL A 332
LEU A 344
LYS A 358
LEU A 460
 None
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-3.8A)
735  A 469 ( 4.2A)
None
735  A 469 (-4.3A)
 0.64A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 CYH A 276
LEU A 321
ILE A 339
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.39A 3g9eA-2p54A:
37.6		 3g9eA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
SER A 280
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.86A 3g9eA-2p54A:
37.6		 3g9eA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 10 PHE A 273
GLN A 277
ILE A 317
MET A 320
VAL A 332
LEU A 344
LYS A 358
 735  A 469 (-3.7A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
None
735  A 469 (-3.8A)
735  A 469 ( 4.2A)
None
 0.49A 3gwxA-2p54A:
37.9		 3gwxA-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
THR A 279
THR A 283
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-3.6A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.47A 3gwxA-2p54A:
37.9		 3gwxA-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
THR A 283
ILE A 354
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
None
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.77A 3gwxA-2p54A:
37.9		 3gwxA-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 CYH A 276
THR A 279
THR A 283
GLU A 286
LEU A 321
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-3.6A)
None
None
735  A 469 ( 4.3A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.64A 3gwxB-2p54A:
38.0		 3gwxB-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 THR A 279
ILE A 339
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.6A)
735  A 469 ( 4.1A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.49A 3gwxB-2p54A:
38.0		 3gwxB-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 247
PHE A 273
GLN A 277
ILE A 317
MET A 320
VAL A 332
LEU A 344
 None
735  A 469 (-3.7A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
None
735  A 469 (-3.8A)
735  A 469 ( 4.2A)
 0.59A 3gwxB-2p54A:
38.0		 3gwxB-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 CYH A 276
LEU A 321
ILE A 339
LYS A 358
HIS A 440
 735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
None
735  A 469 (-4.0A)
 1.45A 3qt0A-2p54A:
36.6		 3qt0A-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A 195
GLU A 519
TYR A 237
LEU A 211
 None
None
C14  A1735 ( 4.4A)
None
 1.15A 3rqwC-1w6jA:
2.2
3rqwD-1w6jA:
2.4		 3rqwC-1w6jA:
16.55
3rqwD-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 GLU A 519
TYR A 237
LEU A 211
PHE A 195
 None
C14  A1735 ( 4.4A)
None
None
 1.10A 3rqwF-1w6jA:
1.7
3rqwJ-1w6jA:
undetectable		 3rqwF-1w6jA:
16.55
3rqwJ-1w6jA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		12 / 12 PHE A 273
CYH A 275
CYH A 276
THR A 279
SER A 280
TYR A 314
VAL A 332
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-3.7A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 (-3.8A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.32A 3sp6A-2p54A:
41.7		 3sp6A-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 275
CYH A 276
TYR A 464
ILE A 354
HIS A 440
 735  A 469 (-3.7A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-4.6A)
735  A 469 (-3.7A)
735  A 469 (-4.0A)
 1.47A 3sp6A-2p54A:
41.7		 3sp6A-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 TYR A 314
VAL A 324
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.9A)
None
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.50A 3sp6A-2p54A:
41.7		 3sp6A-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 LEU A 247
CYH A 276
THR A 279
ILE A 317
ILE A 354
 None
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-3.7A)
 1.07A 3sp9A-2p54A:
37.5		 3sp9A-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 247
PHE A 273
CYH A 276
THR A 279
ILE A 317
HIS A 440
TYR A 464
 None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.32A 3sp9A-2p54A:
37.5		 3sp9A-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 258
PHE A 273
CYH A 276
THR A 279
ILE A 317
HIS A 440
TYR A 464
 None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.27A 3sp9A-2p54A:
37.5		 3sp9A-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 247
PHE A 273
CYH A 276
THR A 279
ILE A 317
HIS A 440
TYR A 464
 None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.31A 3sp9B-2p54A:
37.7		 3sp9B-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 258
PHE A 273
CYH A 276
THR A 279
ILE A 317
HIS A 440
TYR A 464
 None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.29A 3sp9B-2p54A:
37.7		 3sp9B-2p54A:
70.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 LEU A 247
THR A 246
LEU A 344
THR A 340
ILE A 339
 None
None
735  A 469 ( 4.2A)
None
735  A 469 ( 4.1A)
 1.01A 3tbgD-2p54A:
undetectable		 3tbgD-2p54A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 10 CYH E 464
ASP E 443
CYH E 441
GLY E 445
ALA E 446
 ZN  E 735 (-2.2A)
None
ZN  E 735 (-2.4A)
None
ZN  E 735 ( 4.4A)
 1.17A 3ucjA-3lvrE:
4.3		 3ucjA-3lvrE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 10 CYH E 464
ASP E 443
CYH E 441
GLY E 445
ALA E 446
 ZN  E 735 (-2.2A)
None
ZN  E 735 (-2.4A)
None
ZN  E 735 ( 4.4A)
 1.13A 3ucjB-3lvrE:
undetectable		 3ucjB-3lvrE:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 PHE A 273
CYH A 276
SER A 280
ILE A 317
LEU A 321
LEU A 344
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.51A 3vn2A-2p54A:
38.6		 3vn2A-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.75A 4emaA-2p54A:
36.7		 4emaA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ILE A 666
LEU A 670
GLY A 677
SER A 711
ASN A 735
 ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
SER  A 711 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.20A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ILE A 702
ILE A 666
LEU A 670
GLY A 677
ASN A 735
 ILE  A 702 ( 0.7A)
ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.09A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
SER A 280
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.71A 4o8fA-2p54A:
34.9		 4o8fA-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 276
SER A 280
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.73A 4o8fA-2p54A:
34.9		 4o8fA-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 SER A 280
VAL A 324
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.8A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.24A 4o8fA-2p54A:
34.9		 4o8fA-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.76A 4o8fB-2p54A:
34.5		 4o8fB-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 CYH A 276
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.49A 4o8fB-2p54A:
34.5		 4o8fB-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
SER A 280
LEU A 321
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.90A 4o8fB-2p54A:
34.5		 4o8fB-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 HIS A 440
LEU A 321
VAL A 324
LEU A 460
TYR A 464
 735  A 469 (-4.0A)
735  A 469 ( 4.3A)
None
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.45A 4o8fB-2p54A:
34.5		 4o8fB-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 ILE A 272
PHE A 273
ILE A 317
LEU A 344
 735  A 469 ( 4.2A)
735  A 469 (-3.7A)
735  A 469 ( 4.8A)
735  A 469 ( 4.2A)
 0.74A 4o8fB-2p54A:
34.5		 4o8fB-2p54A:
61.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.81A 4xldA-2p54A:
36.7		 4xldA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 9 SER A 280
GLU A 286
MET A 320
LEU A 321
 735  A 469 (-2.8A)
None
None
735  A 469 ( 4.3A)
 0.39A 4xtaA-2p54A:
35.1		 4xtaA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 ILE A 272
SER A 280
LEU A 321
MET A 355
 735  A 469 ( 4.2A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.61A 4xtaB-2p54A:
33.4		 4xtaB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 PHE A 273
CYH A 276
SER A 280
ILE A 317
MET A 355
HIS A 440
LEU A 456
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.69A 4xumA-2p54A:
37.3		 4xumA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Thermobifida
fusca) 		4 / 6 LEU A 604
SER A 548
PRO A 547
GLU A  40
 None
ZN  A 735 (-3.9A)
None
CBK  A 702 ( 3.4A)
 1.17A 5b8iA-4jjjA:
undetectable		 5b8iA-4jjjA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.84A 5ji0D-2p54A:
37.5		 5ji0D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 276
GLN A 277
SER A 280
LEU A 321
MET A 355
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 1.05A 5ji0D-2p54A:
37.5		 5ji0D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.6A)
 1.19A 5ji0D-2p54A:
37.5		 5ji0D-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.72A 5y2oA-2p54A:
37.5		 5y2oA-2p54A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.82A 5y2oA-2p54A:
37.5		 5y2oA-2p54A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 LEU A 247
CYH A 276
LEU A 321
MET A 355
HIS A 440
 None
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
 0.84A 5y2tA-2p54A:
36.2		 5y2tA-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 247
PHE A 273
CYH A 276
GLN A 277
LEU A 321
MET A 355
 None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.72A 5y2tA-2p54A:
36.2		 5y2tA-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
CYH A 276
GLN A 277
LEU A 321
ILE A 339
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
 1.23A 5y2tA-2p54A:
36.2		 5y2tA-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 247
ARG A 271
ILE A 272
CYH A 276
GLN A 277
ILE A 317
HIS A 440
 None
None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
 0.98A 5y2tB-2p54A:
34.2		 5y2tB-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 247
ILE A 272
CYH A 276
GLN A 277
ILE A 317
LEU A 321
HIS A 440
 None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-4.0A)
 0.75A 5y2tB-2p54A:
34.2		 5y2tB-2p54A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 LEU A 247
ILE A 272
LEU A 321
MET A 355
LEU A 460
 None
735  A 469 ( 4.2A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
 0.62A 5ycnA-2p54A:
37.6		 5ycnA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 CYH A 276
SER A 280
HIS A 440
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.68A 5ycnA-2p54A:
37.6		 5ycnA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 PHE A 273
CYH A 276
SER A 280
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.6A)
 0.52A 5ycnA-2p54A:
37.6		 5ycnA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 CYH A 276
LEU A 321
ILE A 339
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.37A 5ycpA-2p54A:
38.0		 5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.76A 5ycpA-2p54A:
38.0		 5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.90A 5ycpA-2p54A:
38.0		 5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 PHE A 273
CYH A 276
GLN A 277
HIS A 440
TYR A 314
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 (-4.0A)
735  A 469 (-3.9A)
 1.48A 6md4A-2p54A:
36.5		 6md4A-2p54A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 273
CYH A 276
GLN A 277
LEU A 321
ILE A 339
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.39A 6md4A-2p54A:
36.5		 6md4A-2p54A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 PHE A 273
CYH A 276
GLN A 277
SER A 280
LEU A 321
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.70A 6md4A-2p54A:
36.5		 6md4A-2p54A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 PHE A 185
GLY A  52
GLY A  49
ASP A  55
ILE A 215
 None
None
EDO  A1735 (-2.9A)
None
None
 1.10A 6mhtA-4c1oA:
undetectable		 6mhtA-4c1oA:
18.47