SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6Z4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 7 VAL A 232
LEU A 236
PHE A 241
LEU A 242
ALA A 309
 None
None
6Z4  A 502 ( 4.8A)
None
6Z4  A 502 (-3.6A)
 0.27A 1j8uA-5l01A:
43.4		 1j8uA-5l01A:
53.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		9 / 12 VAL A 232
LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
6Z4  A 502 ( 4.8A)
None
None
FE  A 501 ( 4.8A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.97A 1kw0A-5l01A:
41.0		 1kw0A-5l01A:
53.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		8 / 12 VAL A 232
LEU A 236
PHE A 241
LEU A 242
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
6Z4  A 502 ( 4.8A)
None
FE  A 501 ( 4.8A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.89A 1mmkA-5l01A:
41.2		 1mmkA-5l01A:
53.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		9 / 11 VAL A 232
LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
6Z4  A 502 ( 4.8A)
None
None
FE  A 501 ( 4.8A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.89A 1mmtA-5l01A:
41.2		 1mmtA-5l01A:
53.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A 206
VAL A 256
ASP A 269
SER A 336
TYR A 193
 None
None
None
6Z4  A 502 (-2.5A)
None
 1.43A 1xvaA-5l01A:
undetectable		 1xvaA-5l01A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 SER A 339
THR A 265
SER A 337
PRO A 262
 None
6Z4  A 502 (-4.4A)
6Z4  A 502 (-4.0A)
None
 1.32A 2hdnB-5l01A:
undetectable
2hdnC-5l01A:
undetectable
2hdnD-5l01A:
undetectable		 2hdnB-5l01A:
20.77
2hdnC-5l01A:
5.18
2hdnD-5l01A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 501 ( 3.2A)
6Z4  A 502 (-3.8A)
None
None
 1.26A 4ndnC-5l01A:
undetectable		 4ndnC-5l01A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 6 PHE A 241
HIS A 272
HIS A 277
TYR A 312
GLU A 317
 6Z4  A 502 ( 4.8A)
FE  A 501 ( 3.2A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.49A 4pahA-5l01A:
43.1		 4pahA-5l01A:
65.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		3 / 5 GLY A 276
GLY A 333
GLU A 317
 None
6Z4  A 502 (-3.9A)
FE  A 501 ( 1.8A)
 0.44A 4z2eA-5l01A:
undetectable
4z2eD-5l01A:
undetectable		 4z2eA-5l01A:
21.69
4z2eD-5l01A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 501 ( 3.2A)
6Z4  A 502 (-3.8A)
None
None
 1.31A 5a1iA-5l01A:
undetectable		 5a1iA-5l01A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 4 HIS A 272
HIS A 277
TYR A 312
GLU A 317
 FE  A 501 ( 3.2A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.44A 5pahA-5l01A:
42.9		 5pahA-5l01A:
65.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 ILE A 366
GLU A 340
TYR A 264
ALA A 332
GLY A 331
 6Z4  A 502 (-3.8A)
None
6Z4  A 502 (-4.3A)
FE  A 501 ( 4.6A)
None
 1.08A 5uxdB-5l01A:
undetectable		 5uxdB-5l01A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 ILE A 358
ILE A 293
PHE A 389
PHE A 241
 None
None
None
6Z4  A 502 ( 4.8A)
 0.96A 5vkqA-5l01A:
undetectable
5vkqB-5l01A:
undetectable		 5vkqA-5l01A:
13.23
5vkqB-5l01A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 PHE A 241
ILE A 358
ILE A 293
PHE A 389
 6Z4  A 502 ( 4.8A)
None
None
None
 0.93A 5vkqA-5l01A:
undetectable
5vkqD-5l01A:
undetectable		 5vkqA-5l01A:
13.23
5vkqD-5l01A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 8 GLY A 276
TRP A 174
ARG A 257
ASP A 269
 None
None
6Z4  A 502 (-2.8A)
None
 1.05A 5vlmB-5l01A:
undetectable		 5vlmB-5l01A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 8 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 501 ( 3.2A)
6Z4  A 502 (-3.8A)
None
None
 1.24A 6fcbA-5l01A:
undetectable		 6fcbA-5l01A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 501 ( 3.2A)
6Z4  A 502 (-3.8A)
None
None
 1.31A 6g6rA-5l01A:
undetectable		 6g6rA-5l01A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 6 PRO A 268
HIS A 272
HIS A 277
TYR A 312
GLU A 317
 6Z4  A 502 (-3.8A)
FE  A 501 ( 3.2A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.61A 6pahA-5l01A:
42.9		 6pahA-5l01A:
65.91