SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6YR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLN A  43
ILE A  30
TYR A  31
 None
None
6YR  A 300 (-3.8A)
 0.73A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLN A  80
ILE A  68
TYR A  69
 None
None
6YR  A 301 (-3.9A)
 0.72A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLN A 118
ILE A 105
TYR A 106
 None
None
6YR  A 302 (-3.9A)
 0.76A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 11 LEU A  48
ARG A  12
ILE A  88
GLY A  52
SER A  14
 6YR  A 301 ( 4.6A)
SO4  A 310 ( 2.9A)
None
None
None
 1.33A 3bpxA-5fsbA:
undetectable
3bpxB-5fsbA:
undetectable		 3bpxA-5fsbA:
19.30
3bpxB-5fsbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 11 VAL A 134
GLY A 136
TYR A 144
ALA A 104
TYR A 106
 None
None
6YR  A 303 (-3.9A)
None
6YR  A 302 (-3.9A)
 1.36A 3qxyB-5fsbA:
undetectable
3qxyQ-5fsbA:
undetectable		 3qxyB-5fsbA:
16.34
3qxyQ-5fsbA:
6.55