SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6UY'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
6 / 12 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
0.93A 1uwhA-5ko1A:
26.9
1uwhA-5ko1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 ALA A 228
LYS A 230
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
0.88A 1uwhB-5ko1A:
26.8
1uwhB-5ko1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
6 / 12 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
0.93A 1uwjA-5ko1A:
8.6
1uwjA-5ko1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
6 / 12 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
0.92A 1uwjB-5ko1A:
8.6
1uwjB-5ko1A:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
GLY A 289
LEU A 338
ALA A 348
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
0.76A 2gqgA-5ko1A:
26.8
2gqgA-5ko1A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.74A 2gqgA-5ko1A:
26.8
2gqgA-5ko1A:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
LEU A 338
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.64A 2y6oA-5ko1A:
28.2
2y6oA-5ko1A:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.81A 2zvaA-5ko1A:
28.1
2zvaA-5ko1A:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 MET A 283
PHE A 232
ILE A 281
LEU A 317
GLU A 327
6UY  A 501 (-3.8A)
None
None
None
None
1.26A 3aocC-5ko1A:
undetectable
3aocC-5ko1A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
9 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.83A 3k54A-5ko1A:
27.4
3k54A-5ko1A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
0.79A 3og7A-5ko1A:
26.1
3og7A-5ko1A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 LEU A 209
ALA A 228
LEU A 263
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.38A 3zbfA-5ko1A:
28.2
3zbfA-5ko1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 ALA A 228
LYS A 230
LEU A 263
ILE A 281
HIS A 329
LEU A 338
ALA A 348
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
None
None
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
0.73A 4c8bA-5ko1A:
27.3
4c8bA-5ko1A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 ALA A 228
LYS A 230
ILE A 262
LEU A 263
HIS A 329
LEU A 338
ALA A 348
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
None
None
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
0.67A 4c8bB-5ko1A:
27.1
4c8bB-5ko1A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
0.58A 4mxoA-5ko1A:
27.1
4mxoA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
ILE A 281
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.67A 4mxoB-5ko1A:
27.5
4mxoB-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
ILE A 281
TYR A 285
GLY A 289
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
0.76A 4mxxA-5ko1A:
27.3
4mxxA-5ko1A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
TYR A 285
GLY A 289
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
0.75A 4mxxA-5ko1A:
27.3
4mxxA-5ko1A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 LEU A 209
ALA A 228
LYS A 230
MET A 254
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.74A 4mxxA-5ko1A:
27.3
4mxxA-5ko1A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
GLU A 250
ILE A 281
MET A 283
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-3.8A)
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.85A 4mxyA-5ko1A:
27.5
4mxyA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
ILE A 281
MET A 283
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-3.8A)
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.75A 4mxyA-5ko1A:
27.5
4mxyA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
GLU A 250
ILE A 281
MET A 283
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-3.8A)
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.85A 4mxzA-5ko1A:
27.5
4mxzA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
ILE A 281
MET A 283
TYR A 285
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-3.8A)
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.75A 4mxzA-5ko1A:
27.5
4mxzA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
6 / 12 ALA A 228
LYS A 230
CYH A 286
GLY A 289
HIS A 329
LEU A 338
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
6UY  A 501 ( 4.3A)
None
6UY  A 501 (-4.5A)
0.51A 4u0iA-5ko1A:
26.7
4u0iA-5ko1A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
6 / 11 LEU A 209
ALA A 228
GLY A 289
ASN A 336
LEU A 338
ALA A 348
None
6UY  A 501 (-3.4A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.4A)
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
0.62A 4wa9A-5ko1A:
23.2
4wa9A-5ko1A:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
4 / 6 LEU A 209
ALA A 228
MET A 283
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-3.8A)
6UY  A 501 (-4.5A)
0.93A 4wboC-5ko1A:
20.7
4wboC-5ko1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.83A 4wkqA-5ko1A:
26.2
4wkqA-5ko1A:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
LEU A 338
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.70A 4xliB-5ko1A:
27.3
4xliB-5ko1A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
8 / 12 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
0.66A 4xliB-5ko1A:
27.3
4xliB-5ko1A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
0.78A 4xv2B-5ko1A:
26.1
4xv2B-5ko1A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
0.85A 5cswA-5ko1A:
25.3
5cswA-5ko1A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
0.84A 5cswB-5ko1A:
25.2
5cswB-5ko1A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 12 LEU A 209
ALA A 228
LEU A 263
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.68A 5h2uC-5ko1A:
24.9
5h2uC-5ko1A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 ALA A 228
LYS A 230
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
0.86A 5hi2A-5ko1A:
26.5
5hi2A-5ko1A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 ALA A 228
LYS A 230
GLU A 250
ILE A 281
TYR A 285
GLY A 289
LEU A 338
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.62A 5i9xA-5ko1A:
28.6
5i9xA-5ko1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
7 / 12 ALA A 228
LYS A 230
GLU A 250
MET A 254
TYR A 285
GLY A 289
LEU A 338
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.61A 5i9yA-5ko1A:
28.6
5i9yA-5ko1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo
sapiens)
5 / 9 LEU A 209
ALA A 228
MET A 283
CYH A 286
GLY A 289
None
6UY  A 501 (-3.4A)
6UY  A 501 (-3.8A)
6UY  A 501 (-4.3A)
6UY  A 501 ( 4.3A)
0.86A 5w5vA-5ko1A:
13.9
5w5vA-5ko1A:
17.71