SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6UI'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.95A 1iepA-4usfA:
18.8
1iepA-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.14A 1iepA-4usfA:
18.8
1iepA-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
GLY A 114
ALA A 172
ASP A 173
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 ( 4.1A)
None
1.16A 1iepB-4usfA:
18.9
1iepB-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 9 LEU A  40
VAL A  48
ALA A  61
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.41A 1xbbA-4usfA:
23.6
1xbbA-4usfA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 LEU A  40
ALA A  61
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.68A 2gqgA-4usfA:
17.9
2gqgA-4usfA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.10A 2hyyA-4usfA:
18.9
2hyyA-4usfA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.14A 2hyyB-4usfA:
18.8
2hyyB-4usfA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 VAL A  48
ALA A  61
VAL A  92
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
None
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.97A 2hyyC-4usfA:
25.0
2hyyC-4usfA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A  48
ALA A  61
ILE A 106
PHE A 110
LEU A 162
ALA A 172
None
6UI  A 700 (-3.3A)
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.89A 2hyyD-4usfA:
18.8
2hyyD-4usfA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.11A 2hyyD-4usfA:
18.8
2hyyD-4usfA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
ALA A  61
VAL A  92
ILE A 106
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.72A 2zvaA-4usfA:
19.2
2zvaA-4usfA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
GLY A  41
ALA A  61
PHE A 110
CYH A 111
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
1.15A 3c7qA-4usfA:
18.0
3c7qA-4usfA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 10 LEU A  40
VAL A  48
VAL A  92
ILE A 106
PHE A 110
6UI  A 700 ( 4.9A)
None
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
0.75A 3cs9A-4usfA:
18.5
3cs9A-4usfA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 ALA A  61
GLY A 114
HIS A 153
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 ( 4.1A)
None
0.83A 3cs9B-4usfA:
19.7
3cs9B-4usfA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 9 LEU A  40
VAL A  48
LYS A  63
VAL A  92
ILE A 106
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-4.5A)
None
6UI  A 700 (-3.5A)
1.02A 3cs9C-4usfA:
24.4
3cs9C-4usfA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
VAL A  92
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.93A 3gvuA-4usfA:
18.9
3gvuA-4usfA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A  61
VAL A  92
HIS A 153
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.72A 3ik3A-4usfA:
24.7
3ik3A-4usfA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A  61
VAL A  92
HIS A 153
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.73A 3ik3B-4usfA:
24.4
3ik3B-4usfA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.15A 3k5vA-4usfA:
23.9
3k5vA-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.11A 3k5vB-4usfA:
18.2
3k5vB-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 9 ALA A  61
LYS A  63
PHE A 110
GLY A 114
LEU A 162
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.69A 3miyB-4usfA:
24.8
3miyB-4usfA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.80A 3ms9A-4usfA:
18.9
3ms9A-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.11A 3ms9A-4usfA:
18.9
3ms9A-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.91A 3ms9B-4usfA:
18.8
3ms9B-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.13A 3ms9B-4usfA:
18.8
3ms9B-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.83A 3mssA-4usfA:
19.0
3mssA-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.11A 3mssA-4usfA:
19.0
3mssA-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.83A 3mssC-4usfA:
19.0
3mssC-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A  48
ALA A  61
PHE A 110
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.12A 3mssC-4usfA:
19.0
3mssC-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.91A 3mssD-4usfA:
19.0
3mssD-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 LEU A  40
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.92A 3mssD-4usfA:
19.0
3mssD-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
VAL A  92
GLY A 114
LEU A 162
ALA A 172
ASP A 173
None
6UI  A 700 (-3.3A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.73A 3oezA-4usfA:
19.1
3oezA-4usfA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A  61
VAL A  92
GLY A 114
HIS A 153
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
None
6UI  A 700 ( 4.2A)
None
6UI  A 700 ( 4.1A)
None
0.79A 3oxzA-4usfA:
23.6
3oxzA-4usfA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
ALA A  61
LYS A  63
VAL A  92
ILE A 106
PHE A 110
LEU A 162
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
0.76A 3ue4A-4usfA:
17.7
3ue4A-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
ALA A  61
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.58A 3ue4A-4usfA:
17.7
3ue4A-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 LEU A  40
VAL A  48
ALA A  61
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.68A 3ue4B-4usfA:
23.7
3ue4B-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 8 VAL A  92
CYH A 111
LEU A 162
ASP A 173
None
6UI  A 700 (-4.2A)
6UI  A 700 (-4.2A)
None
0.54A 3wzeA-4usfA:
18.0
3wzeA-4usfA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 11 ALA A  61
VAL A  92
PHE A 110
CYH A 111
GLY A 114
LEU A 162
6UI  A 700 (-3.3A)
None
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.64A 4agdA-4usfA:
21.6
4agdA-4usfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 11 LEU A  40
ALA A  61
LYS A  63
PHE A 110
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
1.02A 4agdA-4usfA:
21.6
4agdA-4usfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 11 LEU A  40
ALA A  61
PHE A 110
CYH A 111
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.70A 4agdA-4usfA:
21.6
4agdA-4usfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 9 LEU A  40
VAL A  48
ALA A  61
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.56A 4anqA-4usfA:
23.6
4anqA-4usfA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 9 LEU A  40
VAL A  48
ALA A  61
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.56A 4ansA-4usfA:
23.5
4ansA-4usfA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
LYS A  63
VAL A  92
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.77A 4mxxB-4usfA:
17.8
4mxxB-4usfA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
VAL A  92
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.56A 4mxyB-4usfA:
17.7
4mxyB-4usfA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
ALA A  61
VAL A  92
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.56A 4mxzB-4usfA:
17.7
4mxzB-4usfA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0U_A_ADNA501_1
(AURORA KINASE A)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 6 VAL A  48
ALA A  61
LYS A  63
LEU A 162
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-4.2A)
0.76A 4o0uA-4usfA:
19.6
4o0uA-4usfA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 LEU A  40
VAL A  48
LYS A  63
VAL A  92
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-4.5A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.81A 4otwA-4usfA:
17.3
4otwA-4usfA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 LEU A  40
VAL A  48
ALA A  61
PHE A 110
GLY A 114
ASN A 160
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
1.02A 4twpB-4usfA:
18.3
4twpB-4usfA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A  61
LEU A 146
HIS A 153
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.93A 4uxqA-4usfA:
18.3
4uxqA-4usfA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 11 LEU A  40
ALA A  61
GLY A 114
ASN A 160
LEU A 162
ALA A 172
PHE A 174
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.01A 4wa9A-4usfA:
21.5
4wa9A-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 ALA A  61
PHE A 110
GLY A 114
ASN A 160
LEU A 162
ALA A 172
PHE A 174
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.31A 4wa9B-4usfA:
18.0
4wa9B-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
PHE A 110
GLY A 114
ASN A 160
LEU A 162
ALA A 172
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
1.04A 4wa9B-4usfA:
18.0
4wa9B-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 LEU A  40
VAL A  48
ALA A  61
LYS A  63
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.90A 4xeyA-4usfA:
17.5
4xeyA-4usfA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 LEU A  40
VAL A  48
ALA A  61
LYS A  63
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.86A 4xeyB-4usfA:
16.3
4xeyB-4usfA:
25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 LEU A  40
GLY A  41
ALA A  61
LYS A  63
PHE A 110
CYH A 111
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.78A 5ajqA-4usfA:
36.2
5ajqA-4usfA:
75.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 LEU A  40
ALA A  61
ILE A 106
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.55A 5h2uC-4usfA:
17.7
5h2uC-4usfA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 LEU A  40
VAL A  48
ALA A  61
ILE A 106
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.57A 5h2uD-4usfA:
17.7
5h2uD-4usfA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A  61
VAL A  92
HIS A 153
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.69A 5mo4A-4usfA:
14.8
5mo4A-4usfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A  48
ALA A  61
LYS A  63
ILE A 106
GLY A 114
LEU A 162
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.81A 5p9iA-4usfA:
18.2
5p9iA-4usfA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A  48
ALA A  61
VAL A  92
ILE A 106
PHE A 110
LEU A 162
ALA A 172
None
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.95A 6hd6A-4usfA:
23.9
6hd6A-4usfA:
12.45