SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6U7'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | ALA B 690THR B 739CYH B 742LEU B 777HIS B 784 | 6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)NoneNone | 0.55A | 1uwhA-5kkrB:18.7 | 1uwhA-5kkrB:34.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690THR B 739LEU B 777HIS B 784 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)NoneNone | 0.48A | 1uwjA-5kkrB:10.1 | 1uwjA-5kkrB:34.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | ILE B 672VAL B 680ALA B 690THR B 739CYH B 742LEU B 777 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)None | 1.07A | 1uwjB-5kkrB:10.1 | 1uwjB-5kkrB:34.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | ILE B 672VAL B 680ALA B 690THR B 739LEU B 777HIS B 784 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)NoneNone | 0.87A | 1uwjB-5kkrB:10.1 | 1uwjB-5kkrB:34.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BBT_B_FMMB91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | VAL B 680ALA B 690THR B 739LEU B 741THR B 802PHE B 804 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-4.6A)6U7 B1001 (-3.6A)6U7 B1001 (-3.8A) | 0.65A | 3bbtB-5kkrB:24.7 | 3bbtB-5kkrB:27.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IA4_D_MTXD164_2 (DIHYDROFOLATEREDUCTASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 3 / 3 | ARG B 684ILE B 738THR B 802 | NoneNone6U7 B1001 (-3.6A) | 0.68A | 3ia4D-5kkrB:undetectable | 3ia4D-5kkrB:22.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | ILE B 672VAL B 680ALA B 690THR B 739CYH B 742PHE B 804 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)6U7 B1001 (-3.8A) | 1.01A | 3og7A-5kkrB:17.0 | 3og7A-5kkrB:36.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | ILE B 672VAL B 680ALA B 690THR B 739PHE B 793 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-4.3A) | 0.71A | 3og7A-5kkrB:17.0 | 3og7A-5kkrB:36.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3WZE_A_BAXA1201_2 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 4 / 8 | VAL B 722VAL B 723ILE B 801ASP B 803 | NoneNoneNone6U7 B1001 (-4.6A) | 0.61A | 3wzeA-5kkrB:19.6 | 3wzeA-5kkrB:25.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690THR B 739CYH B 742PHE B 804 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)6U7 B1001 (-3.8A) | 0.80A | 4rzvB-5kkrB:23.5 | 4rzvB-5kkrB:36.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690THR B 739CYH B 742PHE B 793 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)6U7 B1001 (-4.3A) | 0.78A | 5cswA-5kkrB:21.7 | 5cswA-5kkrB:36.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690THR B 739CYH B 742PHE B 793 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)6U7 B1001 (-4.3A) | 0.77A | 5cswB-5kkrB:26.0 | 5cswB-5kkrB:36.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5H2U_D_1N1D504_1 (PROTEIN-TYROSINEKINASE 6) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | VAL B 680ALA B 690ILE B 737THR B 739LEU B 741ASP B 803 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 ( 4.1A)6U7 B1001 (-4.0A)6U7 B1001 (-4.6A)6U7 B1001 (-4.6A) | 0.63A | 5h2uD-5kkrB:22.3 | 5h2uD-5kkrB:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HES_A_032A401_1 (MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690ILE B 737THR B 739PHE B 804 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 ( 4.1A)6U7 B1001 (-4.0A)6U7 B1001 (-3.8A) | 0.70A | 5hesA-5kkrB:9.1 | 5hesA-5kkrB:28.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690ILE B 737THR B 739PHE B 793 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 ( 4.1A)6U7 B1001 (-4.0A)6U7 B1001 (-4.3A) | 0.54A | 5hieA-5kkrB:25.1 | 5hieA-5kkrB:35.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690ILE B 737THR B 739PHE B 793 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 ( 4.1A)6U7 B1001 (-4.0A)6U7 B1001 (-4.3A) | 0.55A | 5hieB-5kkrB:25.2 | 5hieB-5kkrB:35.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 12 | VAL B 680ALA B 690ILE B 737THR B 739PHE B 793 | 6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 ( 4.1A)6U7 B1001 (-4.0A)6U7 B1001 (-4.3A) | 0.56A | 5hieD-5kkrB:25.0 | 5hieD-5kkrB:35.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | GLU B 670ILE B 672GLY B 673ALA B 690CYH B 742ASP B 803 | None6U7 B1001 ( 4.8A)None6U7 B1001 (-3.6A)6U7 B1001 (-3.5A)6U7 B1001 (-4.6A) | 0.65A | 5vc3A-5kkrB:20.5 | 5vc3A-5kkrB:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 6 / 12 | GLU B 670ILE B 672GLY B 673ALA B 690PHE B 793ASP B 803 | None6U7 B1001 ( 4.8A)None6U7 B1001 (-3.6A)6U7 B1001 (-4.3A)6U7 B1001 (-4.6A) | 0.99A | 5vc3A-5kkrB:20.5 | 5vc3A-5kkrB:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VCV_A_1N1A404_2 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 4 / 5 | VAL B 680LEU B 741CYH B 742ASP B 803 | 6U7 B1001 ( 4.3A)6U7 B1001 (-4.6A)6U7 B1001 (-3.5A)6U7 B1001 (-4.6A) | 0.84A | 5vcvA-5kkrB:20.1 | 5vcvA-5kkrB:26.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VCY_A_DB8A401_2 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 4 / 4 | VAL B 723LEU B 741ASN B 791ASP B 803 | None6U7 B1001 (-4.6A)None6U7 B1001 (-4.6A) | 0.84A | 5vcyA-5kkrB:20.1 | 5vcyA-5kkrB:26.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5W5V_A_ANWA701_0 (SERINE/THREONINE-PROTEIN KINASE TBK1) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 5 / 9 | ALA B 690VAL B 723CYH B 742GLY B 744THR B 802 | 6U7 B1001 (-3.6A)None6U7 B1001 (-3.5A)None6U7 B1001 (-3.6A) | 1.14A | 5w5vA-5kkrB:14.5 | 5w5vA-5kkrB:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HU9_S_PCFS603_0 (CYTOCHROME B-C1COMPLEX SUBUNIT 8CYTOCHROME C OXIDASEPOLYPEPTIDE 5A,MITOCHONDRIAL) |
5kkr | KINASE SUPPRESSOR OFRAS 2 (Homosapiens) | 4 / 7 | GLY B 744PHE B 793VAL B 799SER B 749 | None6U7 B1001 (-4.3A)NoneNone | 0.81A | 6hu9S-5kkrB:undetectable6hu9q-5kkrB:undetectable | 6hu9S-5kkrB:16.396hu9q-5kkrB:17.90 |