SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6U7'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 ALA B 690
THR B 739
CYH B 742
LEU B 777
HIS B 784
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
None
None
0.55A 1uwhA-5kkrB:
18.7
1uwhA-5kkrB:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
THR B 739
LEU B 777
HIS B 784
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
None
None
0.48A 1uwjA-5kkrB:
10.1
1uwjA-5kkrB:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 ILE B 672
VAL B 680
ALA B 690
THR B 739
CYH B 742
LEU B 777
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
None
1.07A 1uwjB-5kkrB:
10.1
1uwjB-5kkrB:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 ILE B 672
VAL B 680
ALA B 690
THR B 739
LEU B 777
HIS B 784
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
None
None
0.87A 1uwjB-5kkrB:
10.1
1uwjB-5kkrB:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 VAL B 680
ALA B 690
THR B 739
LEU B 741
THR B 802
PHE B 804
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.6A)
6U7  B1001 (-3.6A)
6U7  B1001 (-3.8A)
0.65A 3bbtB-5kkrB:
24.7
3bbtB-5kkrB:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
3 / 3 ARG B 684
ILE B 738
THR B 802
None
None
6U7  B1001 (-3.6A)
0.68A 3ia4D-5kkrB:
undetectable
3ia4D-5kkrB:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 ILE B 672
VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 804
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-3.8A)
1.01A 3og7A-5kkrB:
17.0
3og7A-5kkrB:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 ILE B 672
VAL B 680
ALA B 690
THR B 739
PHE B 793
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.3A)
0.71A 3og7A-5kkrB:
17.0
3og7A-5kkrB:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
4 / 8 VAL B 722
VAL B 723
ILE B 801
ASP B 803
None
None
None
6U7  B1001 (-4.6A)
0.61A 3wzeA-5kkrB:
19.6
3wzeA-5kkrB:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 804
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-3.8A)
0.80A 4rzvB-5kkrB:
23.5
4rzvB-5kkrB:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 793
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.3A)
0.78A 5cswA-5kkrB:
21.7
5cswA-5kkrB:
36.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 793
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.3A)
0.77A 5cswB-5kkrB:
26.0
5cswB-5kkrB:
36.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 VAL B 680
ALA B 690
ILE B 737
THR B 739
LEU B 741
ASP B 803
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.6A)
6U7  B1001 (-4.6A)
0.63A 5h2uD-5kkrB:
22.3
5h2uD-5kkrB:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
ILE B 737
THR B 739
PHE B 804
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.8A)
0.70A 5hesA-5kkrB:
9.1
5hesA-5kkrB:
28.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
ILE B 737
THR B 739
PHE B 793
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.3A)
0.54A 5hieA-5kkrB:
25.1
5hieA-5kkrB:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
ILE B 737
THR B 739
PHE B 793
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.3A)
0.55A 5hieB-5kkrB:
25.2
5hieB-5kkrB:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 12 VAL B 680
ALA B 690
ILE B 737
THR B 739
PHE B 793
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.3A)
0.56A 5hieD-5kkrB:
25.0
5hieD-5kkrB:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 GLU B 670
ILE B 672
GLY B 673
ALA B 690
CYH B 742
ASP B 803
None
6U7  B1001 ( 4.8A)
None
6U7  B1001 (-3.6A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.6A)
0.65A 5vc3A-5kkrB:
20.5
5vc3A-5kkrB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
6 / 12 GLU B 670
ILE B 672
GLY B 673
ALA B 690
PHE B 793
ASP B 803
None
6U7  B1001 ( 4.8A)
None
6U7  B1001 (-3.6A)
6U7  B1001 (-4.3A)
6U7  B1001 (-4.6A)
0.99A 5vc3A-5kkrB:
20.5
5vc3A-5kkrB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
4 / 5 VAL B 680
LEU B 741
CYH B 742
ASP B 803
6U7  B1001 ( 4.3A)
6U7  B1001 (-4.6A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.6A)
0.84A 5vcvA-5kkrB:
20.1
5vcvA-5kkrB:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
4 / 4 VAL B 723
LEU B 741
ASN B 791
ASP B 803
None
6U7  B1001 (-4.6A)
None
6U7  B1001 (-4.6A)
0.84A 5vcyA-5kkrB:
20.1
5vcyA-5kkrB:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
5 / 9 ALA B 690
VAL B 723
CYH B 742
GLY B 744
THR B 802
6U7  B1001 (-3.6A)
None
6U7  B1001 (-3.5A)
None
6U7  B1001 (-3.6A)
1.14A 5w5vA-5kkrB:
14.5
5w5vA-5kkrB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo
sapiens)
4 / 7 GLY B 744
PHE B 793
VAL B 799
SER B 749
None
6U7  B1001 (-4.3A)
None
None
0.81A 6hu9S-5kkrB:
undetectable
6hu9q-5kkrB:
undetectable
6hu9S-5kkrB:
16.39
6hu9q-5kkrB:
17.90