SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6TO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE
(Arabidopsis
thaliana) 		5 / 9 THR A 223
GLY A 398
MET A 423
LEU A 399
ILE A 394
 None
None
None
6TO  A 800 (-4.0A)
None
 1.48A 3nbqD-5kjuA:
undetectable		 3nbqD-5kjuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 394
PRO A 395
SER A  38
GLY A 393
 None
None
6TO  A 800 ( 4.3A)
None
 0.88A 3tkdB-5kjuA:
undetectable		 3tkdB-5kjuA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 394
PRO A 395
SER A  38
GLY A 393
 None
None
6TO  A 800 ( 4.3A)
None
 0.90A 3tkdA-5kjuA:
undetectable		 3tkdA-5kjuA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  64
PHE A 164
ALA A 155
MET A 151
GLY A 150
 None
None
None
6TO  A 800 (-3.9A)
None
 1.50A 4j7xA-5kjuA:
undetectable		 4j7xA-5kjuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 302
VAL A 301
GLY A 158
HIS A  35
CYH A  86
 6TO  A 800 (-4.2A)
None
6TO  A 800 (-3.5A)
None
None
 1.14A 5ergB-5kjuA:
undetectable		 5ergB-5kjuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA416_0
(AROMATIC
PEROXYGENASE)		 5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE
(Arabidopsis
thaliana) 		4 / 4 LYS A 278
VAL A 355
ARG A 356
TYR A 280
 None
None
6TO  A 800 (-3.9A)
None
 1.47A 6ekzA-5kjuA:
0.0		 6ekzA-5kjuA:
9.93