SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6TM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.40A 1n6cA-5kjmA:
6.7		 1n6cA-5kjmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 10 GLY A  18
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.63A 2h21A-5kjmA:
10.5		 2h21A-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 10 GLY A  20
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 1.17A 2h21A-5kjmA:
10.5		 2h21A-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 10 GLY A  20
LEU A  21
TYR A 240
TYR A 258
PHE A 260
 None
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 1.46A 2h21A-5kjmA:
10.5		 2h21A-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.55A 2h21B-5kjmA:
12.7		 2h21B-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  20
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 1.20A 2h21B-5kjmA:
12.7		 2h21B-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.55A 2h21C-5kjmA:
11.1		 2h21C-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  20
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 1.16A 2h21C-5kjmA:
11.1		 2h21C-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  20
LEU A  21
TYR A 240
TYR A 258
PHE A 260
 None
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 1.45A 2h21C-5kjmA:
11.1		 2h21C-5kjmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  16
HIS A 207
TYR A 240
CYH A 262
CYH A 264
 None
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
 1.09A 2r3aA-5kjmA:
5.9		 2r3aA-5kjmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 HIS A 207
TYR A 240
CYH A 262
CYH A 264
LEU A 254
 None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
None
 1.29A 2r3aA-5kjmA:
5.9		 2r3aA-5kjmA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
GLU A 135
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.59A 3mekA-5kjmA:
43.2		 3mekA-5kjmA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  20
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.13A 3mekA-5kjmA:
43.2		 3mekA-5kjmA:
32.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.44A 3ooiA-5kjmA:
6.0		 3ooiA-5kjmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  16
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.17A 3opeA-5kjmA:
6.4		 3opeA-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.58A 3opeA-5kjmA:
6.4		 3opeA-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.09A 3opeA-5kjmA:
6.4		 3opeA-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		4 / 5 CYH A 209
TYR A 258
THR A 247
THR A 238
 ZN  A 505 (-2.4A)
6TM  A 502 ( 4.2A)
None
None
 1.26A 3q07A-5kjmA:
undetectable		 3q07A-5kjmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		4 / 5 CYH A 209
TYR A 258
THR A 247
THR A 238
 ZN  A 505 (-2.4A)
6TM  A 502 ( 4.2A)
None
None
 1.25A 3q07B-5kjmA:
undetectable		 3q07B-5kjmA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		9 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.65A 3qwpA-5kjmA:
43.2		 3qwpA-5kjmA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.17A 3qwpA-5kjmA:
43.2		 3qwpA-5kjmA:
32.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.64A 3qxyA-5kjmA:
13.6		 3qxyA-5kjmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.53A 3qxyB-5kjmA:
12.8
3qxyQ-5kjmA:
undetectable		 3qxyB-5kjmA:
21.99
3qxyQ-5kjmA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.51A 3rc0A-5kjmA:
12.5		 3rc0A-5kjmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.62A 3rc0B-5kjmA:
13.7		 3rc0B-5kjmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 ASN A 206
HIS A 207
TYR A 240
PHE A 260
CYH A 262
 SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
SAM  A 501 (-3.6A)
ZN  A 505 (-2.3A)
 0.98A 3rq4A-5kjmA:
8.0		 3rq4A-5kjmA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7B_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.11A 3s7bA-5kjmA:
62.1		 3s7bA-5kjmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7F_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2
P53 PEPTIDE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 12 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.26A 3s7fA-5kjmA:
61.9
3s7fI-5kjmA:
undetectable		 3s7fA-5kjmA:
100.00
3s7fI-5kjmA:
5.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7J_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.23A 3s7jA-5kjmA:
60.3		 3s7jA-5kjmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 ASN A 206
HIS A 207
TYR A 240
PHE A 260
CYH A 262
 SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
SAM  A 501 (-3.6A)
ZN  A 505 (-2.3A)
 1.01A 3s8pA-5kjmA:
7.0		 3s8pA-5kjmA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TG4_A_SAMA434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		10 / 10 LYS A  17
ARG A  19
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.20A 3tg4A-5kjmA:
59.8		 3tg4A-5kjmA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		4 / 5 ALA A 222
MET A 205
THR A 238
PHE A 184
 None
None
None
6TM  A 502 (-3.4A)
 1.29A 3vasB-5kjmA:
undetectable		 3vasB-5kjmA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 ASN A 206
HIS A 207
TYR A 240
PHE A 260
CYH A 262
 SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
SAM  A 501 (-3.6A)
ZN  A 505 (-2.3A)
 1.04A 4bupA-5kjmA:
6.9		 4bupA-5kjmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.36A 4e47A-5kjmA:
6.8		 4e47A-5kjmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.35A 4e47B-5kjmA:
5.8		 4e47B-5kjmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.35A 4e47C-5kjmA:
6.8		 4e47C-5kjmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 10 LYS A  17
ARG A  19
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.78A 4ij8A-5kjmA:
7.3
4ij8B-5kjmA:
7.4		 4ij8A-5kjmA:
17.25
4ij8B-5kjmA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 10 LYS A  17
LEU A 204
ASN A 206
HIS A 207
TYR A 240
 None
None
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.95A 4ij8A-5kjmA:
7.3
4ij8B-5kjmA:
7.4		 4ij8A-5kjmA:
17.25
4ij8B-5kjmA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_B_SAMB501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 9 LYS A  17
ARG A  19
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.82A 4ij8A-5kjmA:
7.3
4ij8B-5kjmA:
7.6		 4ij8A-5kjmA:
17.25
4ij8B-5kjmA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.36A 4jdsA-5kjmA:
7.3		 4jdsA-5kjmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.37A 4jdsB-5kjmA:
6.9		 4jdsB-5kjmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.37A 4jdsC-5kjmA:
7.3		 4jdsC-5kjmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.42A 4jlgA-5kjmA:
undetectable		 4jlgA-5kjmA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YND_A_SAMA505_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		10 / 10 LYS A  17
ARG A  19
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.26A 4yndA-5kjmA:
57.7		 4yndA-5kjmA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.00A 4ynmA-5kjmA:
6.5		 4ynmA-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.46A 4ynmB-5kjmA:
6.7		 4ynmB-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  16
HIS A 207
TYR A 240
CYH A 262
CYH A 264
 None
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
 1.03A 4ynpA-5kjmA:
6.5		 4ynpA-5kjmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.17A 4ynpA-5kjmA:
6.5		 4ynpA-5kjmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.37A 4ynpA-5kjmA:
6.5		 4ynpA-5kjmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 10 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.36A 4ynpB-5kjmA:
6.7		 4ynpB-5kjmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.03A 4ypaA-5kjmA:
6.3		 4ypaA-5kjmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.93A 4ypaB-5kjmA:
6.5		 4ypaB-5kjmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.01A 4ypaC-5kjmA:
6.4		 4ypaC-5kjmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.95A 4ypaD-5kjmA:
6.4		 4ypaD-5kjmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.99A 4ypeA-5kjmA:
6.6		 4ypeA-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 11 LYS A  17
GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.97A 4ypeB-5kjmA:
6.8		 4ypeB-5kjmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.46A 4ypuA-5kjmA:
6.6		 4ypuA-5kjmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.16A 4ypuA-5kjmA:
6.6		 4ypuA-5kjmA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		12 / 12 LYS A  17
GLY A  18
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ALA A 203
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-4.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.50A 5arfA-5kjmA:
58.6		 5arfA-5kjmA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ARG_A_SAMA1434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		10 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.60A 5argA-5kjmA:
58.8		 5argA-5kjmA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ARG_A_SAMA1434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		10 / 11 LYS A  17
ARG A  19
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.44A 5argA-5kjmA:
58.8		 5argA-5kjmA:
98.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 182
ASN A 206
HIS A 207
TYR A 240
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.35A 5ayfA-5kjmA:
6.6		 5ayfA-5kjmA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		9 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.64A 5cclA-5kjmA:
42.8		 5cclA-5kjmA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.18A 5cclA-5kjmA:
42.8		 5cclA-5kjmA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
GLU A 135
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.57A 5ccmA-5kjmA:
43.3		 5ccmA-5kjmA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  20
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.16A 5ccmA-5kjmA:
43.3		 5ccmA-5kjmA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		4 / 6 PHE A 184
PHE A  34
GLU A 235
VAL A 236
 6TM  A 502 (-3.4A)
None
None
None
 1.17A 5h4dA-5kjmA:
undetectable		 5h4dA-5kjmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.56A 5jhnA-5kjmA:
6.6		 5jhnA-5kjmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.57A 5jhnB-5kjmA:
6.1		 5jhnB-5kjmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.55A 5jiyA-5kjmA:
6.0		 5jiyA-5kjmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.58A 5jiyB-5kjmA:
6.0		 5jiyB-5kjmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.61A 5jj0B-5kjmA:
6.0		 5jj0B-5kjmA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJK_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.11A 5kjkA-5kjmA:
62.2		 5kjkA-5kjmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJL_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.20A 5kjlA-5kjmA:
60.5		 5kjlA-5kjmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJM_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.00A 5kjmA-5kjmA:
64.1		 5kjmA-5kjmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJN_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		11 / 11 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.34A 5kjnA-5kjmA:
60.8		 5kjnA-5kjmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		3 / 3 ASN A 206
TYR A 240
CYH A 262
 SAM  A 501 (-3.2A)
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.19A 5lsuB-5kjmA:
6.1		 5lsuB-5kjmA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.51A 5t0kA-5kjmA:
6.1		 5t0kA-5kjmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.50A 5t0kB-5kjmA:
4.8		 5t0kB-5kjmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.58A 5t0mB-5kjmA:
5.9		 5t0mB-5kjmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 9 LYS A  17
ARG A  19
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.79A 5tegA-5kjmA:
8.4
5tegD-5kjmA:
undetectable		 5tegA-5kjmA:
17.03
5tegD-5kjmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 9 LYS A  17
LEU A 204
ASN A 206
HIS A 207
TYR A 240
 None
None
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.98A 5tegA-5kjmA:
8.4
5tegD-5kjmA:
undetectable		 5tegA-5kjmA:
17.03
5tegD-5kjmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 10 LYS A  17
GLY A  18
ARG A  19
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.77A 5tegB-5kjmA:
8.6
5tegE-5kjmA:
undetectable		 5tegB-5kjmA:
17.03
5tegE-5kjmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 10 LYS A  17
GLY A  18
LEU A 204
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 ( 4.1A)
None
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.90A 5tegB-5kjmA:
8.6
5tegE-5kjmA:
undetectable		 5tegB-5kjmA:
17.03
5tegE-5kjmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.45A 5ttfA-5kjmA:
5.9		 5ttfA-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.40A 5ttfB-5kjmA:
6.0		 5ttfB-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.39A 5ttfC-5kjmA:
6.0		 5ttfC-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.31A 5ttfD-5kjmA:
6.7		 5ttfD-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.32A 5ttgA-5kjmA:
6.7		 5ttgA-5kjmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.32A 5ttgB-5kjmA:
6.7		 5ttgB-5kjmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.47A 5tuyA-5kjmA:
6.2		 5tuyA-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.55A 5tuyB-5kjmA:
6.7		 5tuyB-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.31A 5tuzA-5kjmA:
6.8		 5tuzA-5kjmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.33A 5tuzB-5kjmA:
6.6		 5tuzB-5kjmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  16
HIS A 207
TYR A 240
CYH A 262
CYH A 264
 None
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
 1.02A 5updA-5kjmA:
6.3		 5updA-5kjmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.54A 5updA-5kjmA:
6.3		 5updA-5kjmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.47A 5v21A-5kjmA:
5.9		 5v21A-5kjmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 HIS A 137
HIS A 207
TYR A 240
CYH A 262
LEU A 254
 SAM  A 501 (-3.9A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
None
 1.11A 5v21A-5kjmA:
5.9		 5v21A-5kjmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.05A 5v21A-5kjmA:
5.9		 5v21A-5kjmA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.46A 5v37A-5kjmA:
43.4		 5v37A-5kjmA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 0.69A 5v37A-5kjmA:
43.4		 5v37A-5kjmA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.22A 5v37A-5kjmA:
43.4		 5v37A-5kjmA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V3H_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		10 / 10 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
SAM  A 501 (-3.6A)
 0.35A 5v3hA-5kjmA:
53.6		 5v3hA-5kjmA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.43A 5v9iA-5kjmA:
5.9		 5v9iA-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.41A 5v9iB-5kjmA:
6.0		 5v9iB-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.33A 5v9iC-5kjmA:
6.0		 5v9iC-5kjmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.32A 5v9jA-5kjmA:
6.7		 5v9jA-5kjmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.31A 5v9jB-5kjmA:
6.0		 5v9jB-5kjmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.49A 5vscA-5kjmA:
5.3		 5vscA-5kjmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.48A 5vscB-5kjmA:
5.9		 5vscB-5kjmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.32A 5vsdA-5kjmA:
6.8		 5vsdA-5kjmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.34A 5vsdB-5kjmA:
6.7		 5vsdB-5kjmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.50A 5vseA-5kjmA:
6.1		 5vseA-5kjmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.50A 5vseB-5kjmA:
5.9		 5vseB-5kjmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.33A 5vsfA-5kjmA:
6.7		 5vsfA-5kjmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.34A 5vsfB-5kjmA:
6.8		 5vsfB-5kjmA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.42A 5xxdA-5kjmA:
43.3		 5xxdA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 0.66A 5xxdA-5kjmA:
43.3		 5xxdA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.24A 5xxdA-5kjmA:
43.3		 5xxdA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXG_A_SAMA502_0
(SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		9 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.63A 5xxgA-5kjmA:
43.3		 5xxgA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXG_A_SAMA502_0
(SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.22A 5xxgA-5kjmA:
43.3		 5xxgA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXJ_A_SAMA505_0
(SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.43A 5xxjA-5kjmA:
43.4		 5xxjA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXJ_A_SAMA505_0
(SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 0.67A 5xxjA-5kjmA:
43.4		 5xxjA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXJ_A_SAMA505_0
(SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.19A 5xxjA-5kjmA:
43.4		 5xxjA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.47A 5yjoA-5kjmA:
43.2		 5yjoA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		8 / 12 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 0.70A 5yjoA-5kjmA:
43.2		 5yjoA-5kjmA:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		6 / 12 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.21A 5yjoA-5kjmA:
43.2		 5yjoA-5kjmA:
33.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.47A 6a5kA-5kjmA:
6.0		 6a5kA-5kjmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.40A 6a5mA-5kjmA:
5.6		 6a5mA-5kjmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 HIS A 207
TYR A 240
CYH A 262
CYH A 264
LEU A 254
 None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
None
 1.21A 6a5mA-5kjmA:
5.6		 6a5mA-5kjmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  16
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.36A 6agoA-5kjmA:
6.3		 6agoA-5kjmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  16
HIS A 207
TYR A 240
CYH A 262
CYH A 264
 None
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
 1.11A 6agoA-5kjmA:
6.3		 6agoA-5kjmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.03A 6agoA-5kjmA:
6.3		 6agoA-5kjmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.29A 6agoA-5kjmA:
6.3		 6agoA-5kjmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.42A 6bp4A-5kjmA:
5.6		 6bp4A-5kjmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  16
HIS A 207
TYR A 240
CYH A 262
CYH A 264
 None
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
 1.04A 6bp4B-5kjmA:
5.6		 6bp4B-5kjmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 11 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.56A 6cenA-5kjmA:
6.0		 6cenA-5kjmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  16
HIS A 207
TYR A 240
CYH A 262
CYH A 264
 None
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
ZN  A 505 (-2.4A)
 1.00A 6ineA-5kjmA:
6.1		 6ineA-5kjmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.46A 6ineA-5kjmA:
6.1		 6ineA-5kjmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.18A 6ineA-5kjmA:
6.1		 6ineA-5kjmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens) 		5 / 12 LYS A  17
GLY A  18
HIS A 207
TYR A 240
CYH A 262
 None
SAM  A 501 ( 4.1A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 1.36A 6ineA-5kjmA:
6.1		 6ineA-5kjmA:
19.63