SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6SJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 12 LEU A  38
LEU A  37
ILE A  61
GLY A  58
LEU A  54
 None
None
6SJ  A 201 (-3.6A)
6SJ  A 201 ( 3.8A)
6SJ  A 201 (-4.2A)
 1.12A 2j7xA-5lawA:
undetectable		 2j7xA-5lawA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 12 LEU A  38
LEU A  37
ILE A  61
GLY A  58
LEU A  54
 None
None
6SJ  A 201 (-3.6A)
6SJ  A 201 ( 3.8A)
6SJ  A 201 (-4.2A)
 1.15A 2yjaB-5lawA:
undetectable		 2yjaB-5lawA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 7 ILE A  19
LYS A  94
ILE A  99
TYR A 104
 None
6SJ  A 201 ( 2.7A)
6SJ  A 201 (-3.5A)
None
 0.83A 3eteD-5lawA:
undetectable
3eteF-5lawA:
undetectable		 3eteD-5lawA:
13.16
3eteF-5lawA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 12 LEU A  38
LEU A  37
ILE A  61
GLY A  58
LEU A  54
 None
None
6SJ  A 201 (-3.6A)
6SJ  A 201 ( 3.8A)
6SJ  A 201 (-4.2A)
 1.10A 4j26A-5lawA:
undetectable		 4j26A-5lawA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 5 ILE A  61
ILE A  74
HIS A  73
VAL A  93
 6SJ  A 201 (-3.6A)
None
None
6SJ  A 201 (-4.3A)
 0.90A 5jmnA-5lawA:
undetectable		 5jmnA-5lawA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 5 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0B-5lawA:
undetectable		 6ew0B-5lawA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 5 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0D-5lawA:
undetectable		 6ew0D-5lawA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 5 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0F-5lawA:
undetectable		 6ew0F-5lawA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 5 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0H-5lawA:
undetectable		 6ew0H-5lawA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 5 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0I-5lawA:
undetectable		 6ew0I-5lawA:
17.24