SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6SB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 PHE B 150
SER B 131
PHE B 101
LEU B 158
 6SB  B 301 (-2.6A)
None
None
None
 1.02A 1qcaA-5kewB:
undetectable		 1qcaA-5kewB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ILE B  54
SER B 123
ILE B 124
ILE B  67
TYR B  39
 None
6SB  B 301 (-2.3A)
6SB  B 301 (-4.2A)
6SB  B 301 ( 4.0A)
None
 1.31A 3qgtA-5kewB:
undetectable		 3qgtA-5kewB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 11 ILE B 124
VAL B  83
VAL B 106
HIS B  50
ILE B  69
 6SB  B 301 (-4.2A)
None
None
6SB  B 301 (-2.9A)
6SB  B 301 (-3.3A)
 1.40A 3rf4A-5kewB:
undetectable
3rf4C-5kewB:
undetectable		 3rf4A-5kewB:
20.27
3rf4C-5kewB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 11 HIS B  50
ILE B  69
ILE B 124
VAL B  83
VAL B 106
 6SB  B 301 (-2.9A)
6SB  B 301 (-3.3A)
6SB  B 301 (-4.2A)
None
None
 1.37A 3rf4A-5kewB:
undetectable
3rf4B-5kewB:
undetectable		 3rf4A-5kewB:
20.27
3rf4B-5kewB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 11 HIS B  50
ILE B  69
ILE B 124
VAL B  83
VAL B 106
 6SB  B 301 (-2.9A)
6SB  B 301 (-3.3A)
6SB  B 301 (-4.2A)
None
None
 1.37A 3rf4B-5kewB:
undetectable
3rf4C-5kewB:
undetectable		 3rf4B-5kewB:
20.27
3rf4C-5kewB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ILE B  54
SER B 123
ILE B 124
ILE B  67
TYR B  39
 None
6SB  B 301 (-2.3A)
6SB  B 301 (-4.2A)
6SB  B 301 ( 4.0A)
None
 1.34A 3um5A-5kewB:
undetectable		 3um5A-5kewB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ILE B  54
SER B 123
ILE B 124
ILE B  67
TYR B  39
 None
6SB  B 301 (-2.3A)
6SB  B 301 (-4.2A)
6SB  B 301 ( 4.0A)
None
 1.33A 3um5B-5kewB:
undetectable		 3um5B-5kewB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 11 ILE B  54
SER B 123
ILE B 124
ILE B  67
TYR B  39
 None
6SB  B 301 (-2.3A)
6SB  B 301 (-4.2A)
6SB  B 301 ( 4.0A)
None
 1.32A 4p68A-5kewB:
undetectable		 4p68A-5kewB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5kew VTRC PROTEIN
(Vibrio
parahaemolyticus) 		5 / 11 LEU B  99
PHE B 150
GLY B 153
ILE B 134
ASN B 133
 None
6SB  B 301 (-2.6A)
None
None
None
 1.36A 5hjiA-5kewB:
undetectable		 5hjiA-5kewB:
19.88