SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6S6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5la7 HEPARANASE
(Homo
sapiens) 		3 / 3 ARG A 303
GLY A 349
SER A 228
 None
6S6  A 613 (-3.7A)
None
 0.64A 2xctB-5la7A:
undetectable		 2xctB-5la7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 10 GLY A  95
GLY A  96
THR A  97
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
6S6  A 613 (-4.1A)
None
None
 1.10A 3fw1A-5la7A:
undetectable		 3fw1A-5la7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 GLY A  95
GLY A  96
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
None
None
 1.10A 4fglC-5la7A:
undetectable		 4fglC-5la7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLY A  95
GLY A  96
THR A  97
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
6S6  A 613 (-4.1A)
None
None
 1.17A 4zvmA-5la7A:
undetectable
4zvmB-5la7A:
undetectable		 4zvmA-5la7A:
18.09
4zvmB-5la7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
ASP A 357
 6S6  A 613 (-3.7A)
None
None
None
 0.78A 5f8yA-5la7A:
undetectable		 5f8yA-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
HIS A 392
 6S6  A 613 (-3.7A)
None
None
None
 0.73A 5f8yA-5la7A:
undetectable		 5f8yA-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
ASP A 357
 6S6  A 613 (-3.7A)
None
None
None
 0.76A 5f8yB-5la7A:
undetectable		 5f8yB-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
HIS A 392
 6S6  A 613 (-3.7A)
None
None
None
 0.69A 5f8yB-5la7A:
undetectable		 5f8yB-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLU A 343
GLY A  95
VAL A 326
LEU A 279
GLY A 269
 6S6  A 613 (-1.9A)
None
None
None
None
 1.18A 5vooA-5la7A:
2.9		 5vooA-5la7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLU A 343
GLY A  95
VAL A 326
LEU A 279
GLY A 269
 6S6  A 613 (-1.9A)
None
None
None
None
 1.17A 5vooC-5la7A:
2.9		 5vooC-5la7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLU A 154
GLU A 343
GLU A 225
HIS A 296
GLY A 223
 EDO  A 612 ( 4.5A)
6S6  A 613 (-1.9A)
6S6  A 613 (-3.4A)
None
None
 1.13A 5xipC-5la7A:
undetectable		 5xipC-5la7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 GLY A 223
ASN A 224
ASP A 267
ARG A  93
 None
6S6  A 613 (-2.9A)
None
6S6  A 613 ( 4.9A)
 1.30A 6dwdB-5la7A:
undetectable
6dwdD-5la7A:
undetectable		 6dwdB-5la7A:
19.73
6dwdD-5la7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 ARG A  93
GLY A 223
ASN A 224
ASP A 267
 6S6  A 613 ( 4.9A)
None
6S6  A 613 (-2.9A)
None
 1.35A 6dwjB-5la7A:
undetectable
6dwjD-5la7A:
undetectable		 6dwjB-5la7A:
19.73
6dwjD-5la7A:
19.73