SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6S2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4y1y GALECTIN-1
(Homo
sapiens) 		6 / 6 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
 0.49A 3galA-4y1yA:
20.0		 3galA-4y1yA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4y26 GALECTIN-7
(Homo
sapiens) 		6 / 6 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
 0.21A 3galA-4y26A:
27.2		 3galA-4y26A:
88.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4y1y GALECTIN-1
(Homo
sapiens) 		6 / 6 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
 0.41A 3galB-4y1yA:
19.6		 3galB-4y1yA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4y26 GALECTIN-7
(Homo
sapiens) 		6 / 6 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
 0.29A 3galB-4y26A:
27.5		 3galB-4y26A:
88.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4y26 GALECTIN-7
(Homo
sapiens) 		4 / 7 ARG A  31
VAL A  60
GLU A  72
ARG A  74
 None
None
6S2  A 202 (-2.8A)
6S2  A 202 (-3.5A)
 1.20A 4mv7A-4y26A:
undetectable		 4mv7A-4y26A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4y1y GALECTIN-1
(Homo
sapiens) 		4 / 5 LEU A   4
VAL A  87
VAL A  23
ARG A  73
 None
CSO  A  88 ( 3.1A)
None
6S2  A 202 (-3.8A)
 1.10A 4r7iA-4y1yA:
undetectable		 4r7iA-4y1yA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4y1y GALECTIN-1
(Homo
sapiens) 		7 / 7 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
6S2  A 202 (-3.8A)
 0.44A 6b8kA-4y1yA:
19.5		 6b8kA-4y1yA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4y26 GALECTIN-7
(Homo
sapiens) 		7 / 7 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
6S2  A 202 (-3.5A)
 0.61A 6b8kA-4y26A:
22.5		 6b8kA-4y26A:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 4y1y GALECTIN-1
(Homo
sapiens) 		8 / 8 HIS A  44
ASN A  46
ARG A  48
HIS A  52
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-4.2A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
6S2  A 202 (-3.8A)
 0.36A 6b94A-4y1yA:
28.7		 6b94A-4y1yA:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 4y26 GALECTIN-7
(Homo
sapiens) 		7 / 8 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
6S2  A 202 (-3.5A)
 0.68A 6b94A-4y26A:
20.0		 6b94A-4y26A:
35.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 4y1y GALECTIN-1
(Homo
sapiens) 		9 / 10 HIS A  44
ASN A  46
ARG A  48
HIS A  52
ASP A  54
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-4.2A)
6S2  A 202 (-3.5A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
6S2  A 202 (-3.8A)
 0.44A 6b94A-4y1yA:
28.7
6b94B-4y1yA:
26.8		 6b94A-4y1yA:
78.79
6b94B-4y1yA:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 4y26 GALECTIN-7
(Homo
sapiens) 		7 / 10 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
6S2  A 202 (-3.5A)
 0.71A 6b94A-4y26A:
20.0
6b94B-4y26A:
19.4		 6b94A-4y26A:
35.51
6b94B-4y26A:
35.51