SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6R9'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 THR A 336
VAL A 411
GLY A 412
TRP A 439
 6R9  A 704 ( 4.9A)
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
6R9  A 704 ( 3.5A)
 0.31A 2p2fA-5k8fA:
57.2		 2p2fA-5k8fA:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 10 TRP A 334
ILE A 335
VAL A 411
GLY A 412
THR A 441
 6R9  A 704 ( 4.2A)
None
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
ATP  A 703 ( 3.7A)
 0.58A 2wd9C-5k8fA:
38.8		 2wd9C-5k8fA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 6 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.16A 2x45A-5k8fA:
undetectable		 2x45A-5k8fA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.16A 2x45C-5k8fA:
undetectable		 2x45C-5k8fA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.17A 3bu1A-5k8fA:
undetectable		 3bu1A-5k8fA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 412
ASP A 436
ILE A 335
GLY A 444
THR A 310
 ATP  A 703 ( 3.4A)
6R9  A 704 ( 3.5A)
None
None
None
 1.18A 3eeyF-5k8fA:
undetectable		 3eeyF-5k8fA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 GLY A 528
THR A 384
PRO A 414
 None
None
6R9  A 704 (-3.3A)
 0.62A 5v5zA-5k8fA:
undetectable		 5v5zA-5k8fA:
20.45