SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6R3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		5 / 11 HIS A 179
ALA A 228
CYH A 145
GLY A 144
ILE A 162
 None
6R3  A 404 ( 4.3A)
None
EDO  A 405 (-4.1A)
None
 1.16A 2uxpB-5k2zA:
undetectable		 2uxpB-5k2zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 6 SER A 120
ARG A 163
GLY A 230
GLY A 169
 6R3  A 404 (-3.1A)
6R3  A 404 (-3.8A)
SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
 0.85A 4koeA-5k2zA:
undetectable
4koeB-5k2zA:
undetectable
4koeC-5k2zA:
undetectable		 4koeA-5k2zA:
22.07
4koeB-5k2zA:
22.07
4koeC-5k2zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 7 ARG A 163
SER A 120
GLY A 230
GLY A 169
 6R3  A 404 (-3.8A)
6R3  A 404 (-3.1A)
SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
 0.84A 4koeA-5k2zA:
undetectable
4koeB-5k2zA:
undetectable
4koeD-5k2zA:
undetectable		 4koeA-5k2zA:
22.07
4koeB-5k2zA:
22.07
4koeD-5k2zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 6 GLY A 230
GLY A 169
SER A 120
ARG A 163
 SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
6R3  A 404 (-3.1A)
6R3  A 404 (-3.8A)
 0.83A 4z53A-5k2zA:
undetectable
4z53B-5k2zA:
undetectable		 4z53A-5k2zA:
19.65
4z53B-5k2zA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 7 ARG A 163
GLY A 230
GLY A 169
SER A 120
 6R3  A 404 (-3.8A)
SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
6R3  A 404 (-3.1A)
 0.79A 4z53A-5k2zA:
undetectable
4z53B-5k2zA:
undetectable		 4z53A-5k2zA:
19.65
4z53B-5k2zA:
19.65