SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6QR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 340
ALA A 344
VAL A 342
 6QR  A 503 (-3.8A)
None
None
 0.93A 1bdwA-5k69A:
undetectable
1bdwB-5k69A:
undetectable		 1bdwA-5k69A:
6.25
1bdwB-5k69A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 6QR  A 503 (-3.9A)
None
None
None
None
 1.40A 1gtnO-5k69A:
undetectable
1gtnP-5k69A:
undetectable		 1gtnO-5k69A:
11.27
1gtnP-5k69A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 6QR  A 503 (-3.9A)
None
None
None
None
 1.41A 1gtnQ-5k69A:
undetectable
1gtnR-5k69A:
undetectable		 1gtnQ-5k69A:
11.27
1gtnR-5k69A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 ASN A 356
MET A 280
GLY A 281
THR A 287
GLY A 332
 6QR  A 503 (-3.6A)
None
None
None
None
 1.11A 1jr1A-5k69A:
undetectable		 1jr1A-5k69A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 8 SER A 351
THR A 278
THR A 380
THR A 287
 6QR  A 503 (-3.7A)
None
None
None
 1.02A 5l4eA-5k69A:
undetectable
5l4eB-5k69A:
undetectable
5l4eC-5k69A:
undetectable
5l4eD-5k69A:
undetectable
5l4eE-5k69A:
undetectable		 5l4eA-5k69A:
22.56
5l4eB-5k69A:
22.56
5l4eC-5k69A:
22.56
5l4eD-5k69A:
22.56
5l4eE-5k69A:
22.56