SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6PG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 11 CYH A 365
SER A 139
HIS A 186
LEU A 352
ILE A 357
 None
None
6PG  A 502 ( 4.9A)
None
None
 1.17A 1ee2A-1pgpA:
8.1		 1ee2A-1pgpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 11 CYH A 365
SER A 139
HIS A 186
LEU A 352
ILE A 357
 None
None
6PG  A 502 ( 4.9A)
None
None
 1.18A 1ee2B-1pgpA:
3.4		 1ee2B-1pgpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 280
GLY A 421
ALA A 423
GLU A 189
ALA A 286
 None
None
None
6PG  A1470 (-3.7A)
None
 1.33A 1vq1A-2w8zA:
6.9		 1vq1A-2w8zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ko8 GLUCONATE KINASE
(Escherichia
coli) 		5 / 12 GLY A  18
ALA A 123
LEU A 160
VAL A 163
ILE A 156
 6PG  A 502 (-3.7A)
None
None
None
None
 0.86A 3adxB-1ko8A:
0.0		 3adxB-1ko8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 11 ARG A 369
TRP A 362
LYS A 184
VAL A 183
GLU A 348
 None
None
6PG  A1471 (-2.6A)
None
None
 1.47A 3bf6H-2iyoA:
undetectable		 3bf6H-2iyoA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 3e7f 6-PHOSPHOGLUCONOLACT
ONASE
(Trypanosoma
brucei) 		4 / 5 VAL A 126
PHE A 105
ARG A 125
ARG A 200
 None
None
None
6PG  A 843 (-2.7A)
 1.40A 3bjwE-3e7fA:
undetectable		 3bjwE-3e7fA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		3 / 3 GLY A 263
THR A 266
ASN A 187
 None
None
6PG  A 502 (-2.9A)
 0.71A 3v4tD-1pgpA:
0.0		 3v4tD-1pgpA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 GLY A 180
ASN A 102
ILE A  98
THR A  80
ILE A  96
 None
6PG  A1471 (-2.9A)
None
None
None
 1.03A 4q5mA-2iyoA:
undetectable		 4q5mA-2iyoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 178
ASN A 102
ILE A  98
THR A  80
ILE A  96
 None
6PG  A1470 (-3.1A)
None
None
None
 1.01A 4q5mA-2w8zA:
undetectable		 4q5mA-2w8zA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3e7f 6-PHOSPHOGLUCONOLACT
ONASE
(Trypanosoma
brucei) 		5 / 12 GLY A 159
HIS A 165
ASP A 163
MET A 194
GLY A 164
 6PG  A 843 ( 4.4A)
6PG  A 843 (-3.5A)
None
6PG  A 843 (-3.7A)
None
 1.14A 4qa0A-3e7fA:
undetectable		 4qa0A-3e7fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3e7f 6-PHOSPHOGLUCONOLACT
ONASE
(Trypanosoma
brucei) 		5 / 12 GLY A 159
HIS A 165
ASP A 163
MET A 194
GLY A 164
 6PG  A 843 ( 4.4A)
6PG  A 843 (-3.5A)
None
6PG  A 843 (-3.7A)
None
 1.16A 4qa2A-3e7fA:
3.6		 4qa2A-3e7fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3e7f 6-PHOSPHOGLUCONOLACT
ONASE
(Trypanosoma
brucei) 		5 / 12 GLY A 159
HIS A 165
ASP A 163
MET A 194
GLY A 164
 6PG  A 843 ( 4.4A)
6PG  A 843 (-3.5A)
None
6PG  A 843 (-3.7A)
None
 1.16A 4qa2B-3e7fA:
undetectable		 4qa2B-3e7fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 GLU A 191
GLY A 189
ILE A 190
SER A 334
GLN A 337
 6PG  A1471 (-2.7A)
None
None
None
None
 1.33A 4xudA-2iyoA:
6.8		 4xudA-2iyoA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
 6PG  A1470 (-3.7A)
None
None
None
6PG  A1470 (-4.5A)
 1.10A 5fsaB-2w8zA:
undetectable		 5fsaB-2w8zA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 LYS A  38
GLY A  15
MET A  73
ASN A 102
LYS A 262
 None
None
None
6PG  A1471 (-2.9A)
6PG  A1471 ( 4.9A)
 1.46A 5kc0A-2iyoA:
1.4		 5kc0A-2iyoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3e7f 6-PHOSPHOGLUCONOLACT
ONASE
(Trypanosoma
brucei) 		5 / 9 ALA A 167
SER A 168
ALA A  43
GLY A 159
GLY A  45
 None
6PG  A 843 ( 4.8A)
None
6PG  A 843 ( 4.4A)
6PG  A 843 ( 3.8A)
 1.20A 6bklE-3e7fA:
undetectable
6bklF-3e7fA:
undetectable
6bklG-3e7fA:
undetectable
6bklH-3e7fA:
undetectable		 6bklE-3e7fA:
6.84
6bklF-3e7fA:
6.84
6bklG-3e7fA:
6.84
6bklH-3e7fA:
6.84