SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6PC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPOR IN C SYNTHETASE)	5gja	1-AMINOCYCLOPROPANE- 1-CARBOXYLATE OXIDASE 2 (Arabidopsis thaliana)	6 / 12	HIS A 180 ASP A 182 LEU A 198 HIS A 237 SER A 249 PHE A 253	ZN A 401 ( 3.4A) ZN A 401 ( 2.2A) None ZN A 401 ( 3.3A) 6PC A 402 ( 4.5A) None	0.62A	1uobA-5gjaA: 21.9	1uobA-5gjaA: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	5gja	1-AMINOCYCLOPROPANE- 1-CARBOXYLATE OXIDASE 2 (Arabidopsis thaliana)	5 / 10	ILE A 187 PHE A 36 TYR A 287 VAL A 239 LEU A 198	6PC A 402 ( 4.7A) None None None None	1.47A	2w98A-5gjaA: undetectable	2w98A-5gjaA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_F_SAMF300_0 (PUTATIVE RRNA METHYLASE)	5gja	1-AMINOCYCLOPROPANE- 1-CARBOXYLATE OXIDASE 2 (Arabidopsis thaliana)	5 / 12	GLY A 35 ILE A 187 GLY A 185 LEU A 200 THR A 181	None 6PC A 402 ( 4.7A) None None None	1.08A	3eeyF-5gjaA: undetectable	3eeyF-5gjaA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0U_B_ASWB1301_1 (DNA TOPOISOMERASE 2-BETA)	4yzz	TRAP TRANSPORTER SOLUTE BINDING PROTEIN (Bordetella bronchiseptica)	4 / 7	ILE A 218 GLY A 184 ALA A 245 GLU A 242	6PC A 404 (-4.3A) None 6PC A 404 ( 3.8A) None	0.94A	4g0uB-4yzzA: undetectable	4g0uB-4yzzA: 18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G5J_A_0WMA1103_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4m1e	PURINE NUCLEOSIDE PHOSPHORYLASE (Planctopirus limnophila)	4 / 5	ARG A 170 MET A 166 HIS A 165 LEU A 229	6PC A 402 (-2.8A) None None None	1.44A	4g5jA-4m1eA: undetectable	4g5jA-4m1eA: 21.49

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UOB_A_PNNA1311_0","DEACETOXYCEPHALOSPORIN C SYNTHETASE","5gja","1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE 2","Arabidopsis thaliana",6,"HIS A 180;ASP A 182;LEU A 198;HIS A 237;SER A 249;PHE A 253"," ZN A 401 ( 3.4A); ZN A 401 ( 2.2A);None; ZN A 401 ( 3.3A);6PC A 402 ( 4.5A);None","0.62A","1uobA-5gjaA:21.9",null],["2W98_A_P1ZA1351_1","PROSTAGLANDIN REDUCTASE 2","5gja","1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE 2","Arabidopsis thaliana",5,"ILE A 187;PHE A  36;TYR A 287;VAL A 239;LEU A 198","6PC A 402 ( 4.7A);None;None;None;None","1.47A","2w98A-5gjaA:undetectable","1uobA-5gjaA:22.16"],["3EEY_F_SAMF300_0","PUTATIVE RRNA METHYLASE","5gja","1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE 2","Arabidopsis thaliana",5,"GLY A  35;ILE A 187;GLY A 185;LEU A 200;THR A 181","None;6PC A 402 ( 4.7A);None;None;None","1.08A","3eeyF-5gjaA:undetectable","2w98A-5gjaA:21.10"],["4G0U_B_ASWB1301_1","DNA TOPOISOMERASE 2-BETA","4yzz","TRAP TRANSPORTER SOLUTE BINDING PROTEIN","Bordetella bronchiseptica",4,"ILE A 218;GLY A 184;ALA A 245;GLU A 242","6PC A 404 (-4.3A);None;6PC A 404 ( 3.8A);None","0.94A","4g0uB-4yzzA:undetectable","3eeyF-5gjaA:19.50"],["4G5J_A_0WMA1103_1","EPIDERMAL GROWTH FACTOR RECEPTOR","4m1e","PURINE NUCLEOSIDE PHOSPHORYLASE","Planctopirus limnophila",4,"ARG A 170;MET A 166;HIS A 165;LEU A 229","6PC A 402 (-2.8A);None;None;None","1.44A","4g5jA-4m1eA:undetectable","4g0uB-4yzzA:18.73"]]