SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6OU'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_B_VIBB503_1 (YKOF)	6br8	PROTEIN A6 HOMOLOG (Fowlpox virus)	4 / 7	ILE A 143 ILE A 140 LYS A 139 THR A 170	6OU A 405 (-4.4A) 6OU A 405 ( 4.5A) None 6OU A 405 (-4.3A)	0.86A	1sbrB-6br8A: undetectable	1sbrB-6br8A: 15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HC4_A_VDXA525_1 (VITAMIN D RECEPTOR)	5jxd	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8 (Mus musculus)	5 / 12	LEU A 51 VAL A 50 SER A 47 LEU A 132 LEU A 171	6OU A 201 (-4.4A) None 6OU A 201 (-3.5A) None 6OU A 201 (-4.9A)	1.29A	2hc4A-5jxdA: undetectable	2hc4A-5jxdA: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2L8M_A_CAMA415_0 (CAMPHOR 5-MONOOXYGENASE)	6br8	PROTEIN A6 HOMOLOG (Fowlpox virus)	5 / 9	VAL A 341 THR A 345 VAL A 357 ASP A 358 ILE A 362	6OU A 401 ( 4.3A) 6OU A 401 (-4.7A) 6OU A 401 ( 4.9A) None PGV A 404 ( 4.1A)	1.46A	2l8mA-6br8A: undetectable	2l8mA-6br8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZLC_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	5jxd	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8 (Mus musculus)	5 / 12	LEU A 51 VAL A 50 SER A 47 LEU A 132 LEU A 171	6OU A 201 (-4.4A) None 6OU A 201 (-3.5A) None 6OU A 201 (-4.9A)	1.33A	2zlcA-5jxdA: undetectable	2zlcA-5jxdA: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8I_A_RO7A1_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR ALPHA)	5jxd	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8 (Mus musculus)	4 / 7	LEU A 132 VAL A 106 LEU A 75 LEU A 182	None 6OU A 201 ( 4.9A) 6OU A 201 ( 4.9A) None	0.95A	3g8iA-5jxdA: undetectable	3g8iA-5jxdA: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W67_A_VIVA301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5jxd	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8 (Mus musculus)	5 / 11	LEU A 128 ILE A 198 ILE A 189 LEU A 185 VAL A 57	None None 6OU A 201 ( 4.9A) None None	0.99A	3w67A-5jxdA: undetectable	3w67A-5jxdA: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W68_C_VIVC301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5jxd	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8 (Mus musculus)	5 / 12	LEU A 128 ILE A 198 ILE A 189 LEU A 185 VAL A 57	None None 6OU A 201 ( 4.9A) None None	1.01A	3w68C-5jxdA: undetectable	3w68C-5jxdA: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FI4_B_DVAB8_0 (14-3-3 PROTEIN SIGMA PRO-SEP-LEU-PRO-DVA)	6br8	PROTEIN A6 HOMOLOG (Fowlpox virus)	4 / 5	SER A 237 VAL A 236 LYS A 234 ASN A 233	None None None 6OU A 405 (-3.7A)	1.46A	6fi4A-6br8A: undetectable 6fi4B-6br8A: undetectable	6fi4A-6br8A: undetectable 6fi4B-6br8A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SBR_B_VIBB503_1","YKOF","6br8","PROTEIN A6 HOMOLOG","Fowlpox virus",4,"ILE A 143;ILE A 140;LYS A 139;THR A 170","6OU A 405 (-4.4A);6OU A 405 ( 4.5A);None;6OU A 405 (-4.3A)","0.86A","1sbrB-6br8A:undetectable",null],["2HC4_A_VDXA525_1","VITAMIN D RECEPTOR","5jxd","TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8","Mus musculus",5,"LEU A  51;VAL A  50;SER A  47;LEU A 132;LEU A 171","6OU A 201 (-4.4A);None;6OU A 201 (-3.5A);None;6OU A 201 (-4.9A)","1.29A","2hc4A-5jxdA:undetectable","1sbrB-6br8A:15.17"],["2L8M_A_CAMA415_0","CAMPHOR 5-MONOOXYGENASE","6br8","PROTEIN A6 HOMOLOG","Fowlpox virus",5,"VAL A 341;THR A 345;VAL A 357;ASP A 358;ILE A 362","6OU A 401 ( 4.3A);6OU A 401 (-4.7A);6OU A 401 ( 4.9A);None;PGV A 404 ( 4.1A)","1.46A","2l8mA-6br8A:undetectable","2hc4A-5jxdA:20.33"],["2ZLC_A_VDXA500_1","VITAMIN D3 RECEPTOR","5jxd","TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8","Mus musculus",5,"LEU A  51;VAL A  50;SER A  47;LEU A 132;LEU A 171","6OU A 201 (-4.4A);None;6OU A 201 (-3.5A);None;6OU A 201 (-4.9A)","1.33A","2zlcA-5jxdA:undetectable","2l8mA-6br8A:undetectable"],["3G8I_A_RO7A1_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA","5jxd","TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8","Mus musculus",4,"LEU A 132;VAL A 106;LEU A  75;LEU A 182","None;6OU A 201 ( 4.9A);6OU A 201 ( 4.9A);None","0.95A","3g8iA-5jxdA:undetectable","2zlcA-5jxdA:22.26"],["3W67_A_VIVA301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5jxd","TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8","Mus musculus",5,"LEU A 128;ILE A 198;ILE A 189;LEU A 185;VAL A  57","None;None;6OU A 201 ( 4.9A);None;None","0.99A","3w67A-5jxdA:undetectable","3g8iA-5jxdA:23.72"],["3W68_C_VIVC301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5jxd","TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8","Mus musculus",5,"LEU A 128;ILE A 198;ILE A 189;LEU A 185;VAL A  57","None;None;6OU A 201 ( 4.9A);None;None","1.01A","3w68C-5jxdA:undetectable","3w67A-5jxdA:23.72"],["6FI4_B_DVAB8_0","14-3-3 PROTEIN SIGMA;PRO-SEP-LEU-PRO-DVA","6br8","PROTEIN A6 HOMOLOG","Fowlpox virus",4,"SER A 237;VAL A 236;LYS A 234;ASN A 233","None;None;None;6OU A 405 (-3.7A)","1.46A","6fi4A-6br8A:undetectable;6fi4B-6br8A:undetectable","3w68C-5jxdA:23.72"]]