SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6OM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 LEU A  10
LEU A  53
ALA A  25
VAL A  98
ILE A   6
 None
None
None
6OM  A 301 (-3.0A)
None
 1.10A 1s9pA-5hzgA:
undetectable		 1s9pA-5hzgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Arabidopsis
thaliana;
Oryza
sativa) 		5 / 12 GLY A 246
ALA A 253
ALA B 600
PHE A 175
ALA A 216
 None
None
None
6OM  A 301 ( 4.9A)
None
 0.94A 3jb1A-5hzgA:
undetectable		 3jb1A-5hzgA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Arabidopsis
thaliana;
Oryza
sativa) 		5 / 12 GLY A 246
ALA A 253
ALA B 600
PHE A 175
ALA A 216
 None
None
None
6OM  A 301 ( 4.9A)
None
 1.01A 3jb3A-5hzgA:
undetectable		 3jb3A-5hzgA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 7 GLY A  27
SER A  97
LEU A 179
PHE A 175
HIS A 247
 6OM  A 301 ( 4.4A)
6OM  A 301 (-1.5A)
None
6OM  A 301 ( 4.9A)
6OM  A 301 (-2.6A)
 1.36A 3o9mA-5hzgA:
11.1		 3o9mA-5hzgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 8 PHE A  28
GLY A  29
TYR A  69
PHE A  66
 6OM  A 301 (-4.3A)
None
None
None
 0.89A 5flcB-5hzgA:
undetectable		 5flcB-5hzgA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 8 PHE A  28
GLY A  29
TYR A  69
PHE A  66
 6OM  A 301 (-4.3A)
None
None
None
 0.90A 5flcF-5hzgA:
undetectable		 5flcF-5hzgA:
11.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 144
 6OM  A 301 (-3.0A)
None
None
None
None
 1.01A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.33A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
PHE A 195
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.15A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.25A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 136
ILE A 141
VAL A 144
PHE A 195
 6OM  A 301 (-3.0A)
None
None
None
None
 1.14A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 144
 6OM  A 301 (-3.0A)
None
None
None
None
 1.03A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.34A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
PHE A 195
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.15A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.26A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 136
ILE A 141
VAL A 144
PHE A 195
 6OM  A 301 (-3.0A)
None
None
None
None
 1.15A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34