SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6MB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
6MB  A 301 (-3.4A)
None
 0.63A 1q8jA-5jq9A:
14.9		 1q8jA-5jq9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ASP A  56
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
6MB  A 301 (-3.4A)
None
 1.23A 2ycjA-5jq9A:
21.2		 2ycjA-5jq9A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
6MB  A 301 (-3.4A)
None
 0.72A 2ycjA-5jq9A:
21.2		 2ycjA-5jq9A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 LEU A 182
LEU A 184
ASP A 185
ASP A  56
SER A  94
 None
None
6MB  A 301 (-3.2A)
None
None
 1.22A 3ko0M-5jq9A:
undetectable
3ko0N-5jq9A:
undetectable
3ko0O-5jq9A:
undetectable
3ko0P-5jq9A:
undetectable		 3ko0M-5jq9A:
15.16
3ko0N-5jq9A:
15.16
3ko0O-5jq9A:
15.16
3ko0P-5jq9A:
15.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 PHE A 190
LYS A 221
SER A 222
 6MB  A 301 (-3.9A)
6MB  A 301 (-2.7A)
6MB  A 301 (-2.6A)
 0.44A 3tyeB-5jq9A:
37.3		 3tyeB-5jq9A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 GLY A 189
PHE A 190
LYS A 221
SER A 222
 6MB  A 301 (-3.6A)
6MB  A 301 (-3.9A)
6MB  A 301 (-2.7A)
6MB  A 301 (-2.6A)
 0.10A 3tzfB-5jq9A:
44.4		 3tzfB-5jq9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		6 / 12 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
6MB  A 301 (-3.4A)
None
 0.73A 4djeB-5jq9A:
21.5		 4djeB-5jq9A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ASP A  56
ASP A  96
ASN A 115
GLY A 217
SER A 219
 None
6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.4A)
None
 0.68A 4djfB-5jq9A:
12.5		 4djfB-5jq9A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 GLU A  74
ASP A  96
ASN A 115
ILE A 103
 None
6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
None
 1.27A 4ii8A-5jq9A:
undetectable		 4ii8A-5jq9A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		4 / 5 LEU A 113
ASP A  96
ARG A 255
ILE A  20
 None
6MB  A 301 (-3.2A)
6MB  A 301 (-3.1A)
None
 1.38A 4mwrA-5jq9A:
undetectable		 4mwrA-5jq9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
 0.32A 5vopA-5jq9A:
18.8		 5vopA-5jq9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5jq9 DIHYDROPTEROATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
 0.30A 5vopB-5jq9A:
8.3		 5vopB-5jq9A:
23.66