SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6L1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 GLY A 290
GLY A 315
THR A 317
ARG A 434
 6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
6L1  A 601 (-3.5A)
6L1  A 601 (-3.6A)
 0.38A 2wd9A-5jjqA:
33.0		 2wd9A-5jjqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 GLY A 290
GLY A 315
THR A 317
ARG A 434
 6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
6L1  A 601 (-3.5A)
6L1  A 601 (-3.6A)
 0.38A 2wd9B-5jjqA:
33.7		 2wd9B-5jjqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 SER A 372
CYH A 313
PHE A 314
LEU A 220
 None
None
6L1  A 601 (-4.4A)
None
 0.90A 3m0wE-5jjqA:
undetectable
3m0wF-5jjqA:
undetectable
3m0wG-5jjqA:
undetectable
3m0wH-5jjqA:
undetectable		 3m0wE-5jjqA:
10.69
3m0wF-5jjqA:
10.69
3m0wG-5jjqA:
10.69
3m0wH-5jjqA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 PHE A 404
GLY A 315
PHE A 314
SER A 319
 None
6L1  A 601 (-4.7A)
6L1  A 601 (-4.4A)
None
 1.08A 3tzfB-5jjqA:
undetectable		 3tzfB-5jjqA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 ASP A 216
GLY A 290
THR A 317
LYS A 429
 6L1  A 601 (-3.5A)
6L1  A 601 (-3.3A)
6L1  A 601 (-3.5A)
6L1  A 601 (-2.7A)
 0.93A 3vnsA-5jjqA:
37.9		 3vnsA-5jjqA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 ASP A 216
PHE A 217
GLY A 290
THR A 317
 6L1  A 601 (-3.5A)
6L1  A 601 ( 4.7A)
6L1  A 601 (-3.3A)
6L1  A 601 (-3.5A)
 0.74A 3vnsA-5jjqA:
37.9		 3vnsA-5jjqA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 ASP A 216
PHE A 217
GLY A 290
GLY A 315
 6L1  A 601 (-3.5A)
6L1  A 601 ( 4.7A)
6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
 0.90A 5n9xA-5jjqA:
38.3		 5n9xA-5jjqA:
33.16