SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6KY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 8 ASP A 109
ASP A  29
TYR A 176
TYR A 295
 HIS  A 505 (-2.3A)
HIS  A 505 ( 4.5A)
6KY  A 504 (-4.0A)
6KY  A 504 (-3.4A)
 1.43A 1ceaA-5jh8A:
undetectable
1ceaB-5jh8A:
undetectable		 1ceaA-5jh8A:
12.70
1ceaB-5jh8A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 TYR A   5
ASP A 109
MET A 174
TYR A 176
ASP A 177
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.3A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
 0.78A 1e9lA-5jh8A:
32.5		 1e9lA-5jh8A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 TYR A   5
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.50A 2a3aA-5jh8A:
31.2		 2a3aA-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.52A 2a3aB-5jh8A:
31.6		 2a3aB-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 ASP A 109
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.89A 2a3bB-5jh8A:
31.5		 2a3bB-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 TYR A   5
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.59A 3g6mA-5jh8A:
31.8		 3g6mA-5jh8A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 4 ARG A 223
ASP A 177
GLY A 218
THR A 268
 None
6KY  A 504 (-2.6A)
None
None
 1.34A 3k4vB-5jh8A:
undetectable		 3k4vB-5jh8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 ASP A 109
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.40A 3wqvA-5jh8A:
33.3		 3wqvA-5jh8A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 ASP A 109
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.40A 3wqwA-5jh8A:
33.4		 3wqwA-5jh8A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 SER A  66
ASP A  44
SER A 142
GLU A 111
TYR A 295
 None
None
HIS  A 505 ( 3.6A)
HIS  A 505 (-2.8A)
6KY  A 504 (-3.4A)
 1.26A 5iqbA-5jh8A:
undetectable		 5iqbA-5jh8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 SER A  66
ASP A  44
SER A 142
GLU A 111
TYR A 295
 None
None
HIS  A 505 ( 3.6A)
HIS  A 505 (-2.8A)
6KY  A 504 (-3.4A)
 1.33A 5iqbD-5jh8A:
undetectable		 5iqbD-5jh8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 TYR A 219
GLY A 218
THR A 271
GLY A  63
 6KY  A 504 (-3.7A)
None
None
None
 0.72A 5jlcA-5jh8A:
undetectable		 5jlcA-5jh8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 145
PRO A 144
ASP A 197
ASP A 192
ASP A 177
 None
None
None
None
6KY  A 504 (-2.6A)
 1.24A 5wwsB-5jh8A:
undetectable		 5wwsB-5jh8A:
21.97