SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6KB'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1S2A_A_IMNA2001_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TRP A 89 HIS A 120 GLU A 189 TYR A 213 SER A 214	None 6KB A 401 ( 4.0A) None 6KB A 401 (-3.4A) 6KB A 401 (-2.7A)	0.27A	1s2aA-5jgyA: 39.9	1s2aA-5jgyA: 39.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_J_TACJ5888_1 (ELONGATION FACTOR EF-TU)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 6	THR A 85 ASP A 54 SER A 254 VAL A 210	None 6KB A 401 (-3.7A) None None	1.30A	2hdnI-5jgyA: undetectable 2hdnJ-5jgyA: 2.2 2hdnL-5jgyA: 2.4	2hdnI-5jgyA: 9.96 2hdnJ-5jgyA: 21.57 2hdnL-5jgyA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_L_TACL6888_1 (ELONGATION FACTOR EF-TU)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 6	SER A 254 VAL A 210 THR A 85 ASP A 54	None None None 6KB A 401 (-3.7A)	1.25A	2hdnJ-5jgyA: 2.2 2hdnK-5jgyA: undetectable 2hdnL-5jgyA: 2.4	2hdnJ-5jgyA: 21.57 2hdnK-5jgyA: 9.96 2hdnL-5jgyA: 21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2INE_A_PACA317_0 (ALDOSE REDUCTASE)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 5	TRP A 31 TYR A 59 HIS A 120 TRP A 121	EDO A 402 ( 3.2A) 6KB A 401 ( 4.6A) 6KB A 401 ( 4.0A) 6KB A 401 ( 4.4A)	0.34A	2ineA-5jgyA: 41.8	2ineA-5jgyA: 39.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ISF_A_PACA317_0 (ALDOSE REDUCTASE)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 5	TRP A 31 TYR A 59 HIS A 120 TRP A 121	EDO A 402 ( 3.2A) 6KB A 401 ( 4.6A) 6KB A 401 ( 4.0A) 6KB A 401 ( 4.4A)	0.33A	2isfA-5jgyA: 41.6	2isfA-5jgyA: 39.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TYR A 59 ILE A 119 VAL A 164 ILE A 162 VAL A 146	6KB A 401 ( 4.6A) None None None None	1.24A	3fpjB-5jgyA: undetectable	3fpjB-5jgyA: 22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R43_A_ID8A332_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TYR A 59 TRP A 89 HIS A 120 ASN A 166 TYR A 213	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) 6KB A 401 (-3.5A) 6KB A 401 (-3.4A)	0.26A	3r43A-5jgyA: 40.0	3r43A-5jgyA: 38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R6I_A_JMSA332_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TYR A 59 TRP A 89 HIS A 120 ASN A 166 TYR A 213	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) 6KB A 401 (-3.5A) 6KB A 401 (-3.4A)	0.26A	3r6iA-5jgyA: 39.9	3r6iA-5jgyA: 38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RX3_A_SUZA317_1 (ALDOSE REDUCTASE)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 10	TRP A 31 TYR A 59 HIS A 120 TRP A 121 LEU A 299	EDO A 402 ( 3.2A) 6KB A 401 ( 4.6A) 6KB A 401 ( 4.0A) 6KB A 401 ( 4.4A) EDO A 404 (-4.3A)	1.00A	3rx3A-5jgyA: 41.7	3rx3A-5jgyA: 39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3S3G_A_TLTA317_1 (ALDOSE REDUCTASE)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 7	TRP A 31 TYR A 59 HIS A 120 TRP A 121	EDO A 402 ( 3.2A) 6KB A 401 ( 4.6A) 6KB A 401 ( 4.0A) 6KB A 401 ( 4.4A)	0.43A	3s3gA-5jgyA: 41.8	3s3gA-5jgyA: 39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UG8_A_IMNA2001_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TRP A 89 ASN A 166 TYR A 213 SER A 214 SER A 218	None 6KB A 401 (-3.5A) 6KB A 401 (-3.4A) 6KB A 401 (-2.7A) 6KB A 401 (-2.7A)	0.74A	3ug8A-5jgyA: 39.9	3ug8A-5jgyA: 38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UG8_A_IMNA2001_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	6 / 12	TYR A 59 TRP A 89 HIS A 120 ASN A 166 TYR A 213 SER A 214	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) 6KB A 401 (-3.5A) 6KB A 401 (-3.4A) 6KB A 401 (-2.7A)	0.36A	3ug8A-5jgyA: 39.9	3ug8A-5jgyA: 38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UGR_A_IMNA2001_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TRP A 89 HIS A 120 TYR A 213 SER A 214 PHE A 300	None 6KB A 401 ( 4.0A) 6KB A 401 (-3.4A) 6KB A 401 (-2.7A) None	1.05A	3ugrA-5jgyA: 39.7	3ugrA-5jgyA: 38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UGR_A_IMNA2001_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TRP A 89 HIS A 120 TYR A 213 SER A 214 SER A 218	None 6KB A 401 ( 4.0A) 6KB A 401 (-3.4A) 6KB A 401 (-2.7A) 6KB A 401 (-2.7A)	0.75A	3ugrA-5jgyA: 39.7	3ugrA-5jgyA: 38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UZZ_B_ASDB501_1 (3-OXO-5-BETA-STEROID 4-DEHYDROGENASE)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 8	TYR A 59 HIS A 120 LEU A 299 MET A 131	6KB A 401 ( 4.6A) 6KB A 401 ( 4.0A) EDO A 404 (-4.3A) None	1.05A	3uzzB-5jgyA: 40.5	3uzzB-5jgyA: 37.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 8	TRP A 31 TRP A 89 HIS A 120 TRP A 121	EDO A 402 ( 3.2A) None 6KB A 401 ( 4.0A) 6KB A 401 ( 4.4A)	0.33A	3v35A-5jgyA: 42.0	3v35A-5jgyA: 39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4JTR_A_IBPA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	4 / 8	TYR A 59 TRP A 89 HIS A 120 LEU A 294	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) 6KB A 401 ( 4.8A)	0.57A	4jtrA-5jgyA: 40.1	4jtrA-5jgyA: 38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVV_A_GBMA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 9	TYR A 59 TRP A 89 HIS A 120 ASN A 166 TYR A 213	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) 6KB A 401 (-3.5A) 6KB A 401 (-3.4A)	0.22A	4yvvA-5jgyA: 39.8	4yvvA-5jgyA: 37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TYR A 59 TRP A 89 HIS A 120 LEU A 125 ASN A 166	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) None 6KB A 401 (-3.5A)	0.27A	4yvxA-5jgyA: 39.6	4yvxA-5jgyA: 37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5jgy	ALDOSE REDUCTASE, AKR4C13 (Zea mays)	5 / 12	TYR A 59 TRP A 89 HIS A 120 LEU A 125 ASN A 166	6KB A 401 ( 4.6A) None 6KB A 401 ( 4.0A) None 6KB A 401 (-3.5A)	0.24A	4yvxB-5jgyA: 39.5	4yvxB-5jgyA: 37.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S2A_A_IMNA2001_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TRP A  89;HIS A 120;GLU A 189;TYR A 213;SER A 214","None;6KB A 401 ( 4.0A);None;6KB A 401 (-3.4A);6KB A 401 (-2.7A)","0.27A","1s2aA-5jgyA:39.9",null],["2HDN_J_TACJ5888_1","ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"THR A  85;ASP A  54;SER A 254;VAL A 210","None;6KB A 401 (-3.7A);None;None","1.30A","2hdnI-5jgyA:undetectable;2hdnJ-5jgyA:2.2;2hdnL-5jgyA:2.4","1s2aA-5jgyA:39.32"],["2HDN_L_TACL6888_1","ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"SER A 254;VAL A 210;THR A  85;ASP A  54","None;None;None;6KB A 401 (-3.7A)","1.25A","2hdnJ-5jgyA:2.2;2hdnK-5jgyA:undetectable;2hdnL-5jgyA:2.4","2hdnI-5jgyA:9.96;2hdnJ-5jgyA:21.57;2hdnL-5jgyA:21.57"],["2INE_A_PACA317_0","ALDOSE REDUCTASE","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"TRP A  31;TYR A  59;HIS A 120;TRP A 121","EDO A 402 ( 3.2A);6KB A 401 ( 4.6A);6KB A 401 ( 4.0A);6KB A 401 ( 4.4A)","0.34A","2ineA-5jgyA:41.8","2hdnJ-5jgyA:21.57;2hdnK-5jgyA:9.96;2hdnL-5jgyA:21.57"],["2ISF_A_PACA317_0","ALDOSE REDUCTASE","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"TRP A  31;TYR A  59;HIS A 120;TRP A 121","EDO A 402 ( 3.2A);6KB A 401 ( 4.6A);6KB A 401 ( 4.0A);6KB A 401 ( 4.4A)","0.33A","2isfA-5jgyA:41.6","2ineA-5jgyA:39.71"],["3FPJ_B_SAMB301_0","PUTATIVE UNCHARACTERIZED PROTEIN","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TYR A  59;ILE A 119;VAL A 164;ILE A 162;VAL A 146","6KB A 401 ( 4.6A);None;None;None;None","1.24A","3fpjB-5jgyA:undetectable","2isfA-5jgyA:39.71"],["3R43_A_ID8A332_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TYR A  59;TRP A  89;HIS A 120;ASN A 166;TYR A 213","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);6KB A 401 (-3.5A);6KB A 401 (-3.4A)","0.26A","3r43A-5jgyA:40.0","3fpjB-5jgyA:22.68"],["3R6I_A_JMSA332_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TYR A  59;TRP A  89;HIS A 120;ASN A 166;TYR A 213","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);6KB A 401 (-3.5A);6KB A 401 (-3.4A)","0.26A","3r6iA-5jgyA:39.9","3r43A-5jgyA:38.81"],["3RX3_A_SUZA317_1","ALDOSE REDUCTASE","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TRP A  31;TYR A  59;HIS A 120;TRP A 121;LEU A 299","EDO A 402 ( 3.2A);6KB A 401 ( 4.6A);6KB A 401 ( 4.0A);6KB A 401 ( 4.4A);EDO A 404 (-4.3A)","1.00A","3rx3A-5jgyA:41.7","3r6iA-5jgyA:38.81"],["3S3G_A_TLTA317_1","ALDOSE REDUCTASE","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"TRP A  31;TYR A  59;HIS A 120;TRP A 121","EDO A 402 ( 3.2A);6KB A 401 ( 4.6A);6KB A 401 ( 4.0A);6KB A 401 ( 4.4A)","0.43A","3s3gA-5jgyA:41.8","3rx3A-5jgyA:39.33"],["3UG8_A_IMNA2001_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TRP A  89;ASN A 166;TYR A 213;SER A 214;SER A 218","None;6KB A 401 (-3.5A);6KB A 401 (-3.4A);6KB A 401 (-2.7A);6KB A 401 (-2.7A)","0.74A","3ug8A-5jgyA:39.9","3s3gA-5jgyA:39.33"],["3UG8_A_IMNA2001_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",6,"TYR A  59;TRP A  89;HIS A 120;ASN A 166;TYR A 213;SER A 214","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);6KB A 401 (-3.5A);6KB A 401 (-3.4A);6KB A 401 (-2.7A)","0.36A","3ug8A-5jgyA:39.9","3ug8A-5jgyA:38.81"],["3UGR_A_IMNA2001_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TRP A  89;HIS A 120;TYR A 213;SER A 214;PHE A 300","None;6KB A 401 ( 4.0A);6KB A 401 (-3.4A);6KB A 401 (-2.7A);None","1.05A","3ugrA-5jgyA:39.7","3ug8A-5jgyA:38.81"],["3UGR_A_IMNA2001_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TRP A  89;HIS A 120;TYR A 213;SER A 214;SER A 218","None;6KB A 401 ( 4.0A);6KB A 401 (-3.4A);6KB A 401 (-2.7A);6KB A 401 (-2.7A)","0.75A","3ugrA-5jgyA:39.7","3ugrA-5jgyA:38.81"],["3UZZ_B_ASDB501_1","3-OXO-5-BETA-STEROID 4-DEHYDROGENASE","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"TYR A  59;HIS A 120;LEU A 299;MET A 131","6KB A 401 ( 4.6A);6KB A 401 ( 4.0A);EDO A 404 (-4.3A);None","1.05A","3uzzB-5jgyA:40.5","3ugrA-5jgyA:38.81"],["3V35_A_NTIA317_1","ALDOSE REDUCTASE","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"TRP A  31;TRP A  89;HIS A 120;TRP A 121","EDO A 402 ( 3.2A);None;6KB A 401 ( 4.0A);6KB A 401 ( 4.4A)","0.33A","3v35A-5jgyA:42.0","3uzzB-5jgyA:37.37"],["4JTR_A_IBPA401_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",4,"TYR A  59;TRP A  89;HIS A 120;LEU A 294","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);6KB A 401 ( 4.8A)","0.57A","4jtrA-5jgyA:40.1","3v35A-5jgyA:39.33"],["4YVV_A_GBMA402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TYR A  59;TRP A  89;HIS A 120;ASN A 166;TYR A 213","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);6KB A 401 (-3.5A);6KB A 401 (-3.4A)","0.22A","4yvvA-5jgyA:39.8","4jtrA-5jgyA:38.44"],["4YVX_A_GMRA401_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TYR A  59;TRP A  89;HIS A 120;LEU A 125;ASN A 166","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);None;6KB A 401 (-3.5A)","0.27A","4yvxA-5jgyA:39.6","4yvvA-5jgyA:37.65"],["4YVX_B_GMRB401_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5jgy","ALDOSE REDUCTASE, AKR4C13","Zea mays",5,"TYR A  59;TRP A  89;HIS A 120;LEU A 125;ASN A 166","6KB A 401 ( 4.6A);None;6KB A 401 ( 4.0A);None;6KB A 401 (-3.5A)","0.24A","4yvxB-5jgyA:39.5","4yvxA-5jgyA:37.65"]]