SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6HJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		11 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
LEU A 788
LEU A 792
MET A 793
GLY A 796
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.38A 1m17A-5j9zA:
40.8		 1m17A-5j9zA:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 THR A 854
ASP A 855
GLY A 857
ILE A 759
GLN A 787
 6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
None
None
None
 1.27A 1oltA-5j9zA:
undetectable		 1oltA-5j9zA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 790
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.75A 1xbbA-5j9zA:
33.4		 1xbbA-5j9zA:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		10 / 12 ALA A 743
GLY A 796
CYH A 797
LEU A 799
ASP A 800
ARG A 803
LEU A 844
THR A 854
ASP A 855
PHE A 856
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
None
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
None
 0.81A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A 718
VAL A 726
CYH A 775
LEU A 777
LEU A 788
LEU A 792
MET A 793
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
None
None
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
 0.60A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 9 VAL A 726
LYS A 745
CYH A 775
LEU A 777
LEU A 788
LEU A 792
MET A 793
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
None
None
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
 0.68A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.62A 2gqgA-5j9zA:
32.4		 2gqgA-5j9zA:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 718
LYS A 745
VAL A 765
MET A 766
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.1A)
 0.55A 2hyyC-5j9zA:
30.4		 2hyyC-5j9zA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 718
VAL A 765
MET A 766
MET A 793
 6HJ  A1101 ( 4.6A)
None
6HJ  A1101 ( 4.1A)
None
 0.94A 2hyyC-5j9zA:
30.4		 2hyyC-5j9zA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		10 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
LEU A 788
GLY A 796
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.54A 2itoA-5j9zA:
44.0		 2itoA-5j9zA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		11 / 12 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
LEU A 788
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.62A 2ityA-5j9zA:
44.4		 2ityA-5j9zA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		11 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
ASP A 800
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.56A 2itzA-5j9zA:
44.1		 2itzA-5j9zA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.36A 2xp2A-5j9zA:
32.9		 2xp2A-5j9zA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LYS A 716
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 None
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.40A 2y6oA-5j9zA:
34.1		 2y6oA-5j9zA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LEU A 792
MET A 793
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.48A 2y7jA-5j9zA:
24.2		 2y7jA-5j9zA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 726
ALA A 743
LEU A 792
MET A 793
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.35A 2y7jB-5j9zA:
24.9		 2y7jB-5j9zA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 726
ALA A 743
LEU A 792
MET A 793
GLY A 796
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.30A 2y7jC-5j9zA:
24.3		 2y7jC-5j9zA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 726
ALA A 743
LEU A 792
MET A 793
GLY A 796
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.30A 2y7jD-5j9zA:
24.7		 2y7jD-5j9zA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.50A 2zvaA-5j9zA:
32.5		 2zvaA-5j9zA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 718
ALA A 743
LYS A 745
LEU A 792
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.39A 3aoxA-5j9zA:
31.6		 3aoxA-5j9zA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 743
LEU A 792
GLY A 796
LEU A 844
THR A 854
ASP A 855
PHE A 856
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
None
 0.89A 3bbtB-5j9zA:
32.8		 3bbtB-5j9zA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LEU A 777
LEU A 792
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.65A 3bbtB-5j9zA:
32.8		 3bbtB-5j9zA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LEU A 792
GLY A 796
LEU A 844
THR A 854
PHE A 856
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
None
 0.85A 3bbtB-5j9zA:
32.8		 3bbtB-5j9zA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LYS A 745
GLY A 796
LEU A 844
THR A 854
PHE A 856
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
None
 1.00A 3bbtD-5j9zA:
33.8		 3bbtD-5j9zA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LYS A 745
LEU A 788
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.81A 3bbtD-5j9zA:
33.8		 3bbtD-5j9zA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 718
GLY A 719
ALA A 743
LYS A 745
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.61A 3c7qA-5j9zA:
30.3		 3c7qA-5j9zA:
33.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 743
GLU A 762
VAL A 765
MET A 766
HIS A 835
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.1A)
None
 0.67A 3cs9B-5j9zA:
31.0		 3cs9B-5j9zA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 743
GLU A 762
VAL A 765
MET A 766
HIS A 835
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.1A)
None
 0.79A 3cs9C-5j9zA:
30.0		 3cs9C-5j9zA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.57A 3g5dB-5j9zA:
32.7		 3g5dB-5j9zA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 774
LEU A 792
MET A 793
ILE A 853
 None
6HJ  A1101 ( 4.9A)
None
None
 0.88A 3gcsA-5j9zA:
20.2		 3gcsA-5j9zA:
25.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.53A 3k54A-5j9zA:
30.6		 3k54A-5j9zA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 8 ALA A 743
LYS A 745
GLU A 762
LEU A 788
LEU A 792
MET A 793
 6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
 0.61A 3lfaA-5j9zA:
20.6		 3lfaA-5j9zA:
25.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.50A 3miyB-5j9zA:
26.4		 3miyB-5j9zA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LYS A 745
GLU A 762
VAL A 765
MET A 766
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.85A 3oezB-5j9zA:
31.4		 3oezB-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.60A 3qlgA-5j9zA:
32.1		 3qlgA-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
GLU A 762
MET A 766
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.66A 3qlgB-5j9zA:
32.7		 3qlgB-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		10 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
LEU A 788
LEU A 792
MET A 793
GLY A 796
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.50A 3ug2A-5j9zA:
42.9		 3ug2A-5j9zA:
97.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 790
LEU A 792
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.70A 3ug2A-5j9zA:
42.9		 3ug2A-5j9zA:
97.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 718
ALA A 743
LEU A 792
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.42A 3zbfA-5j9zA:
32.9		 3zbfA-5j9zA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.53A 4agcA-5j9zA:
30.6		 4agcA-5j9zA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.64A 4anqA-5j9zA:
32.5		 4anqA-5j9zA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.30A 4anqA-5j9zA:
32.5		 4anqA-5j9zA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 790
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.71A 4ansA-5j9zA:
32.4		 4ansA-5j9zA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.62A 4ansA-5j9zA:
32.4		 4ansA-5j9zA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.29A 4ansA-5j9zA:
32.4		 4ansA-5j9zA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
ALA A 743
MET A 793
GLY A 796
CYH A 797
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.90A 4hjoA-5j9zA:
35.2		 4hjoA-5j9zA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.67A 4hjoA-5j9zA:
35.2		 4hjoA-5j9zA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
CYH A 797
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.82A 4hjoA-5j9zA:
35.2		 4hjoA-5j9zA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
ALA A 743
LYS A 745
LEU A 788
GLY A 796
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.75A 4i22A-5j9zA:
35.6		 4i22A-5j9zA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LYS A 745
LEU A 788
GLY A 796
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.68A 4i22A-5j9zA:
35.6		 4i22A-5j9zA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LYS A 745
MET A 790
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.86A 4i22A-5j9zA:
35.6		 4i22A-5j9zA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.72A 4mxoA-5j9zA:
32.7		 4mxoA-5j9zA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.64A 4mxoB-5j9zA:
32.8		 4mxoB-5j9zA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
ALA A 743
GLU A 762
MET A 766
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.72A 4mxxA-5j9zA:
32.7		 4mxxA-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.62A 4mxxA-5j9zA:
32.7		 4mxxA-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.66A 4mxxB-5j9zA:
31.2		 4mxxB-5j9zA:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 718
VAL A 726
ALA A 743
LYS A 745
ASN A 842
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.86A 4o0sA-5j9zA:
25.4		 4o0sA-5j9zA:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 743
GLU A 762
MET A 766
LEU A 828
ARG A 836
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
None
None
 1.04A 4qrcA-5j9zA:
30.8		 4qrcA-5j9zA:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASN A 842
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
None
6HJ  A1101 ( 4.8A)
 0.86A 4twpB-5j9zA:
31.6		 4twpB-5j9zA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.39A 4u5jB-5j9zA:
32.4		 4u5jB-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 718
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASN A 842
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
None
6HJ  A1101 ( 4.8A)
 1.03A 4wa9A-5j9zA:
28.1		 4wa9A-5j9zA:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 718
ALA A 743
MET A 793
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.8A)
 0.43A 4wboC-5j9zA:
22.5		 4wboC-5j9zA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		11 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
LEU A 788
LEU A 792
GLY A 796
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.45A 4wkqA-5j9zA:
42.7		 4wkqA-5j9zA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
ALA A 743
GLU A 762
MET A 766
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.55A 4xliA-5j9zA:
32.4		 4xliA-5j9zA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.49A 4xliB-5j9zA:
32.2		 4xliB-5j9zA:
37.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 ALA A 743
LEU A 792
MET A 793
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.8A)
 0.21A 4xoyA-5j9zA:
22.6		 4xoyA-5j9zA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 ALA A 743
LEU A 792
MET A 793
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.8A)
 0.24A 4xp3A-5j9zA:
22.7		 4xp3A-5j9zA:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.71A 5aaaA-5j9zA:
32.8		 5aaaA-5j9zA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.37A 5aaaA-5j9zA:
32.8		 5aaaA-5j9zA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.75A 5aabA-5j9zA:
32.6		 5aabA-5j9zA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.54A 5aabA-5j9zA:
32.6		 5aabA-5j9zA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.80A 5aacA-5j9zA:
32.4		 5aacA-5j9zA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.54A 5aacA-5j9zA:
32.4		 5aacA-5j9zA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.74A 5bvwA-5j9zA:
30.1		 5bvwA-5j9zA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 718
VAL A 726
ALA A 743
LEU A 792
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.33A 5h2uD-5j9zA:
29.0		 5h2uD-5j9zA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
GLU A 804
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
None
6HJ  A1101 ( 4.8A)
 0.71A 5i9yA-5j9zA:
32.7		 5i9yA-5j9zA:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 GLY A 719
GLY A 721
VAL A 726
LYS A 745
 6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
 0.48A 5izjA-5j9zA:
22.8		 5izjA-5j9zA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 GLY A 719
GLY A 721
VAL A 726
LYS A 745
 6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
 0.41A 5j5xA-5j9zA:
22.6		 5j5xA-5j9zA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 10 GLY A 719
VAL A 726
ALA A 743
LEU A 792
MET A 793
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
 0.75A 5lw1E-5j9zA:
15.5		 5lw1E-5j9zA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 9 GLY A 719
VAL A 726
ALA A 743
LEU A 792
MET A 793
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
 0.66A 5lw1H-5j9zA:
20.2		 5lw1H-5j9zA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 9 GLY A 719
VAL A 726
ALA A 743
MET A 790
LEU A 792
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.9A)
 0.77A 5lw1H-5j9zA:
20.2		 5lw1H-5j9zA:
12.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A 718
MET A 793
CYH A 797
ASP A 855
 6HJ  A1101 ( 4.6A)
None
6HJ  A1101 (-1.6A)
6HJ  A1101 (-4.3A)
 0.53A 5p9iA-5j9zA:
29.5		 5p9iA-5j9zA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
LEU A 788
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.6A)
 0.49A 5vcyA-5j9zA:
23.5		 5vcyA-5j9zA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LEU A 788
MET A 790
CYH A 797
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.55A 5yu9A-5j9zA:
35.4		 5yu9A-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LYS A 745
LEU A 788
MET A 790
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.68A 5yu9A-5j9zA:
35.4		 5yu9A-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A 718
GLY A 719
VAL A 726
ALA A 743
MET A 790
CYH A 797
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.78A 5yu9A-5j9zA:
35.4		 5yu9A-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 GLY A 719
VAL A 726
ALA A 743
LEU A 788
MET A 790
CYH A 797
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.58A 5yu9B-5j9zA:
35.8		 5yu9B-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 GLY A 719
VAL A 726
ALA A 743
LYS A 745
LEU A 788
MET A 790
LEU A 844
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.8A)
 0.66A 5yu9B-5j9zA:
35.8		 5yu9B-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 GLY A 719
VAL A 726
ALA A 743
MET A 790
CYH A 797
ASP A 800
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.74A 5yu9B-5j9zA:
35.8		 5yu9B-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 726
ALA A 743
LEU A 788
MET A 790
GLY A 796
CYH A 797
ASP A 800
THR A 854
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 (-3.9A)
 0.49A 5yu9C-5j9zA:
35.2		 5yu9C-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 726
ALA A 743
LYS A 745
LEU A 788
MET A 790
GLY A 796
CYH A 797
THR A 854
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 (-3.9A)
 0.72A 5yu9C-5j9zA:
35.2		 5yu9C-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 726
ALA A 743
MET A 790
GLY A 796
CYH A 797
ASP A 800
THR A 854
ASP A 855
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.72A 5yu9C-5j9zA:
35.2		 5yu9C-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LYS A 745
MET A 790
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.83A 5yu9D-5j9zA:
36.1		 5yu9D-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		9 / 12 VAL A 726
ALA A 743
MET A 790
GLY A 796
CYH A 797
ASP A 800
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.67A 5yu9D-5j9zA:
36.1		 5yu9D-5j9zA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 LYS A 745
LEU A 844
ASP A 855
 6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.69A 5zv2A-5j9zA:
31.2		 5zv2A-5j9zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.79A 6bsdA-5j9zA:
29.6		 6bsdA-5j9zA:
14.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.56A 6fnmA-5j9zA:
33.2		 6fnmA-5j9zA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
 0.50A 6hd6B-5j9zA:
29.9		 6hd6B-5j9zA:
15.35