SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6GT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 264
ALA A  38
ALA A  32
GLY A 272
THR A  55
 None
None
None
None
6GT  A 403 (-3.7A)
 1.07A 3c6gB-5j5dA:
undetectable		 3c6gB-5j5dA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 MET A 251
LEU A 259
LEU A  15
ALA A 218
LEU A 217
 6GT  A 403 ( 4.4A)
None
None
None
None
 1.26A 4m11A-5j5dA:
undetectable		 4m11A-5j5dA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 141
PHE A 210
GLY A 194
LEU A 177
LEU A 225
 None
None
6GT  A 403 (-4.2A)
None
None
 1.24A 5y2tA-5j5dA:
undetectable		 5y2tA-5j5dA:
undetectable