SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6GA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.75A 1j36A-5j6sA:
7.3		 1j36A-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.75A 1j36B-5j6sA:
7.3		 1j36B-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.73A 1j37A-5j6sA:
4.8		 1j37A-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.73A 1j37B-5j6sA:
7.3		 1j37B-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.74A 1o86A-5j6sA:
7.4		 1o86A-5j6sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ILE A 267
ASP A 198
PHE A 199
 None
6GA  A1015 (-3.1A)
None
 0.58A 1uwjB-5j6sA:
undetectable		 1uwjB-5j6sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.99A 1v7zD-5j6sA:
2.5		 1v7zD-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.99A 1v7zE-5j6sA:
2.5		 1v7zE-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.98A 1v7zF-5j6sA:
undetectable		 1v7zF-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		6 / 12 ALA A 335
HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 6GA  A1015 (-4.7A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.73A 2c6nA-5j6sA:
7.3		 2c6nA-5j6sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.82A 2c6nB-5j6sA:
undetectable		 2c6nB-5j6sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 GLU A 337
HIS A 370
GLU A 371
 6GA  A1015 (-4.0A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.79A 2x45B-5j6sA:
undetectable		 2x45B-5j6sA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 GLU A 337
HIS A 370
GLU A 371
 6GA  A1015 (-4.0A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.79A 2x45C-5j6sA:
undetectable		 2x45C-5j6sA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.69A 2x8zA-5j6sA:
6.3		 2x8zA-5j6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.71A 2x91A-5j6sA:
7.3		 2x91A-5j6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.94A 3a6jB-5j6sA:
2.6		 3a6jB-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.95A 3a6jC-5j6sA:
2.4		 3a6jC-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.97A 3a6jE-5j6sA:
undetectable		 3a6jE-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.94A 3a6jF-5j6sA:
2.4		 3a6jF-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.76A 4c2pA-5j6sA:
7.4		 4c2pA-5j6sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 9 GLY A 334
HIS A 370
GLU A 371
GLU A 393
TYR A 455
 6GA  A1015 (-3.7A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.39A 4dprA-5j6sA:
31.8		 4dprA-5j6sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 GLU A 452
ILE A 930
THR A 933
TYR A 892
 6GA  A1015 ( 4.8A)
None
None
6GA  A1015 (-3.8A)
 1.28A 4qwpA-5j6sA:
undetectable		 4qwpA-5j6sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 5 GLU A 452
ILE A 930
THR A 933
TYR A 892
 6GA  A1015 ( 4.8A)
None
None
6GA  A1015 (-3.8A)
 1.32A 4qwpB-5j6sA:
undetectable		 4qwpB-5j6sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		6 / 12 HIS A 370
GLU A 371
HIS A 374
TRP A 386
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
None
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.56A 4r7lA-5j6sA:
41.2		 4r7lA-5j6sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		6 / 12 HIS A 370
GLU A 371
HIS A 374
TRP A 386
PHE A 450
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
None
6GA  A1015 (-3.7A)
6GA  A1015 (-4.0A)
 1.31A 4r7lA-5j6sA:
41.2		 4r7lA-5j6sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ILE A 328
VAL A 196
THR A 197
ILE A 267
PRO A 201
 None
None
None
None
6GA  A1015 ( 4.4A)
 1.19A 6hlpA-5j6sA:
undetectable		 6hlpA-5j6sA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 ILE A 328
ALA A 335
ARG A 345
ASP A 893
 None
6GA  A1015 (-4.7A)
None
None
 0.93A 6hu9m-5j6sA:
undetectable
6hu9q-5j6sA:
undetectable		 6hu9m-5j6sA:
20.56
6hu9q-5j6sA:
7.95