SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6G2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 11 THR A 164
ILE A 161
LEU A 127
ASP A 154
GLY A 156
 None
None
None
6G2  A 901 (-3.4A)
None
 1.12A 1b02A-5j5tA:
undetectable		 1b02A-5j5tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
VAL A  74
ASN A 141
LEU A 143
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.45A 1fmoE-5j5tA:
24.1		 1fmoE-5j5tA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.74A 1iepA-5j5tA:
21.3		 1iepA-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.78A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
MET A  65
PHE A  92
GLY A  95
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 ( 4.7A)
6G2  A 901 ( 4.2A)
 1.01A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		4 / 7 LYS A  45
VAL A  74
ILE A  88
LEU A 143
 6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
 0.65A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.68A 1opjA-5j5tA:
21.1		 1opjA-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
MET A  65
VAL A  74
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.67A 1opjA-5j5tA:
21.1		 1opjA-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
PHE A  92
GLY A  96
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.82A 1opjB-5j5tA:
20.9		 1opjB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
MET A  65
VAL A  74
PHE A  92
GLY A  95
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
TPO  A 145 ( 4.7A)
 0.71A 1opjB-5j5tA:
20.9		 1opjB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.54A 1uwhA-5j5tA:
21.7		 1uwhA-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
LYS A  45
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
None
None
 0.53A 1uwhB-5j5tA:
21.5		 1uwhB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.62A 1uwjA-5j5tA:
21.3		 1uwjA-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ILE A  22
VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.8A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.85A 1uwjB-5j5tA:
21.1		 1uwjB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 VAL A  30
ALA A  43
MET A  90
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.42A 1xbbA-5j5tA:
22.9		 1xbbA-5j5tA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 ILE A  22
VAL A  30
LYS A  45
VAL A  74
ASN A 141
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.69A 2eufB-5j5tA:
24.1		 2eufB-5j5tA:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 11 GLY A  23
GLY A  25
VAL A  30
ALA A  43
MET A  90
LEU A 143
ASP A 154
 None
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.89A 2evaA-5j5tA:
23.7		 2evaA-5j5tA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
ASP A 136
LYS A 138
ASN A 141
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.4A)
 0.80A 2fumA-5j5tA:
25.5		 2fumA-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  90
LYS A 138
ASN A 141
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
None
None
6G2  A 901 (-3.4A)
 0.87A 2fumB-5j5tA:
25.3		 2fumB-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  90
LYS A 138
ASN A 141
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
None
None
6G2  A 901 (-3.4A)
 0.79A 2fumD-5j5tA:
24.6		 2fumD-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
PHE A  92
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 ( 4.2A)
 0.74A 2gqgA-5j5tA:
22.9		 2gqgA-5j5tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.56A 2gqgA-5j5tA:
22.9		 2gqgA-5j5tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.61A 2gqgB-5j5tA:
23.2		 2gqgB-5j5tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.49A 2gqgB-5j5tA:
23.2		 2gqgB-5j5tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.78A 2hyyA-5j5tA:
21.7		 2hyyA-5j5tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 2hyyB-5j5tA:
21.7		 2hyyB-5j5tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
VAL A  74
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.59A 2hyyC-5j5tA:
21.9		 2hyyC-5j5tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
ILE A  88
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.75A 2hyyD-5j5tA:
21.5		 2hyyD-5j5tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
GLY A  96
ASP A 100
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.88A 2itzA-5j5tA:
22.1		 2itzA-5j5tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
GLY A  96
ASP A 100
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.89A 2itzA-5j5tA:
22.1		 2itzA-5j5tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.74A 2oiqA-5j5tA:
21.6		 2oiqA-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.80A 2pl0A-5j5tA:
20.8		 2pl0A-5j5tA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 ILE A  22
ALA A  43
LYS A  45
GLU A  61
MET A  65
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.74A 2y6oA-5j5tA:
22.3		 2y6oA-5j5tA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ILE A  22
ARG A  21
VAL A  30
ALA A  43
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.87A 2y7jA-5j5tA:
25.0		 2y7jA-5j5tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.73A 2zvaA-5j5tA:
23.9		 2zvaA-5j5tA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 2zvaA-5j5tA:
23.9		 2zvaA-5j5tA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
MET A  64
GLY A  96
LEU A 143
ASP A 154
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
None
 1.13A 3bbtD-5j5tA:
21.8		 3bbtD-5j5tA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  43
LYS A  45
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.81A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  95
LEU A 143
 None
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.7A)
6G2  A 901 (-4.7A)
 1.04A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.57A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 10 VAL A  30
LYS A  45
VAL A  74
ILE A  88
PHE A  92
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
 0.55A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
GLY A  96
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
 0.73A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
GLU A  61
MET A  65
GLY A  96
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.67A 3cs9B-5j5tA:
22.0		 3cs9B-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
MET A  65
GLY A  96
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
 0.60A 3cs9B-5j5tA:
22.0		 3cs9B-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 VAL A  30
LYS A  45
VAL A  74
ILE A  88
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
 0.57A 3cs9B-5j5tA:
22.0		 3cs9B-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
PHE A  92
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
None
6G2  A 901 ( 4.2A)
 0.71A 3cs9C-5j5tA:
21.5		 3cs9C-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.75A 3cs9D-5j5tA:
20.4		 3cs9D-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
MET A  65
PHE A  92
GLY A  96
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
 0.54A 3cs9D-5j5tA:
20.4		 3cs9D-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  90
ASN A 141
LEU A 143
ASP A 154
 None
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-3.5A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.67A 3eygA-5j5tA:
23.0		 3eygA-5j5tA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  90
LEU A 143
ASP A 154
 None
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.75A 3fupA-5j5tA:
22.9		 3fupA-5j5tA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 GLY A  23
VAL A  30
ALA A  43
LYS A  45
VAL A  74
MET A  90
LEU A 143
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.60A 3fupB-5j5tA:
22.3		 3fupB-5j5tA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 11 VAL A  30
ALA A  43
VAL A  74
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.45A 3g0eA-5j5tA:
19.7		 3g0eA-5j5tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
ILE A  88
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.59A 3g5dA-5j5tA:
23.0		 3g5dA-5j5tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.51A 3g5dA-5j5tA:
23.0		 3g5dA-5j5tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 3g5dB-5j5tA:
22.8		 3g5dB-5j5tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 3gvuA-5j5tA:
21.7		 3gvuA-5j5tA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 3ik3A-5j5tA:
21.8		 3ik3A-5j5tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 GLU A  61
MET A  65
VAL A  74
HIS A 134
LEU A 143
ALA A 153
 None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.82A 3ik3A-5j5tA:
21.8		 3ik3A-5j5tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.70A 3ik3B-5j5tA:
21.5		 3ik3B-5j5tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.68A 3k54A-5j5tA:
22.1		 3k54A-5j5tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 3k5vA-5j5tA:
20.9		 3k5vA-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.70A 3k5vB-5j5tA:
20.9		 3k5vB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 GLY A  23
VAL A  30
ALA A  43
LYS A  45
VAL A  74
MET A  90
LEU A 143
ALA A 153
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.88A 3lxkA-5j5tA:
22.8		 3lxkA-5j5tA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ILE A  22
ALA A  43
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.55A 3miyB-5j5tA:
22.7		 3miyB-5j5tA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.76A 3ms9A-5j5tA:
21.1		 3ms9A-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 3ms9B-5j5tA:
21.2		 3ms9B-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.77A 3mssA-5j5tA:
21.3		 3mssA-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.60A 3mssB-5j5tA:
21.3		 3mssB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
 0.70A 3mssB-5j5tA:
21.3		 3mssB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.76A 3mssC-5j5tA:
21.2		 3mssC-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.61A 3mssD-5j5tA:
21.3		 3mssD-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		4 / 6 VAL A  30
LYS A  45
VAL A  74
ILE A  88
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
 0.47A 3mssD-5j5tA:
21.3		 3mssD-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
MET A  65
VAL A  74
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.71A 3octA-5j5tA:
22.3		 3octA-5j5tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
VAL A  74
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.67A 3oezA-5j5tA:
21.5		 3oezA-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.72A 3oezB-5j5tA:
21.8		 3oezB-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.74A 3og7A-5j5tA:
22.1		 3og7A-5j5tA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
VAL A  74
GLY A  96
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
 0.67A 3oxzA-5j5tA:
21.6		 3oxzA-5j5tA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.63A 3pyyA-5j5tA:
21.3		 3pyyA-5j5tA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.66A 3pyyB-5j5tA:
20.0		 3pyyB-5j5tA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.74A 3qlgA-5j5tA:
22.1		 3qlgA-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.72A 3qlgB-5j5tA:
22.4		 3qlgB-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.78A 3qlgB-5j5tA:
22.4		 3qlgB-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.56A 3sxrA-5j5tA:
22.8		 3sxrA-5j5tA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ILE A  22
ALA A  43
VAL A  74
PHE A  92
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
 0.36A 3ti1A-5j5tA:
24.3		 3ti1A-5j5tA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.66A 3ue4A-5j5tA:
22.7		 3ue4A-5j5tA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.54A 3ue4B-5j5tA:
22.5		 3ue4B-5j5tA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		4 / 5 LYS A  45
VAL A  74
LEU A 143
ASP A 154
 6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.94A 3wzdA-5j5tA:
21.3		 3wzdA-5j5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
PHE A  92
GLY A  96
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
None
 0.61A 3wzeA-5j5tA:
20.8		 3wzeA-5j5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.65A 3zosA-5j5tA:
21.0		 3zosA-5j5tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.67A 3zosB-5j5tA:
20.9		 3zosB-5j5tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
VAL A  74
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.55A 4ag8A-5j5tA:
20.8		 4ag8A-5j5tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.59A 4agcA-5j5tA:
20.5		 4agcA-5j5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 11 ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.29A 4agdA-5j5tA:
20.1		 4agdA-5j5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 9 ALA A  43
MET A  90
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.69A 4ansA-5j5tA:
23.2		 4ansA-5j5tA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
PHE A  92
GLY A  96
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
None
 0.64A 4asdA-5j5tA:
20.4		 4asdA-5j5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.81A 4bkjB-5j5tA:
20.8		 4bkjB-5j5tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
ILE A  88
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.59A 4c8bA-5j5tA:
13.3		 4c8bA-5j5tA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
ILE A  73
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.56A 4c8bB-5j5tA:
11.2		 4c8bB-5j5tA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.84A 4csvA-5j5tA:
22.4		 4csvA-5j5tA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
ASP A 136
LYS A 138
ASN A 141
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.58A 4i41A-5j5tA:
23.4		 4i41A-5j5tA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 10 ALA A  43
VAL A  74
MET A  90
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.5A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.52A 4ks8A-5j5tA:
29.3		 4ks8A-5j5tA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 10 ILE A  22
ALA A  43
VAL A  74
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.48A 4ks8A-5j5tA:
29.3		 4ks8A-5j5tA:
32.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-3.4A)
 0.85A 4mxoA-5j5tA:
22.7		 4mxoA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
GLY A  96
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-3.4A)
 0.83A 4mxoA-5j5tA:
22.7		 4mxoA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.79A 4mxoB-5j5tA:
22.7		 4mxoB-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.81A 4mxxA-5j5tA:
22.6		 4mxxA-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
GLY A  96
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-3.4A)
 0.86A 4mxyA-5j5tA:
22.9		 4mxyA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.69A 4mxyA-5j5tA:
22.9		 4mxyA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
VAL A  74
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.80A 4mxyB-5j5tA:
22.7		 4mxyB-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
GLY A  96
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-3.4A)
 0.86A 4mxzA-5j5tA:
22.9		 4mxzA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.69A 4mxzA-5j5tA:
22.9		 4mxzA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
VAL A  74
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.80A 4mxzB-5j5tA:
22.7		 4mxzB-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		4 / 6 GLY A  23
VAL A  30
ALA A  43
LEU A 143
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.7A)
 0.20A 4o0wA-5j5tA:
19.8		 4o0wA-5j5tA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 8 ILE A  22
GLY A  25
VAL A  30
ALA A  43
ASN A 141
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.48A 4ogrA-5j5tA:
25.9		 4ogrA-5j5tA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 9 ILE A  22
GLY A  25
VAL A  30
ALA A  43
CYH A  93
ASN A 141
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
TPO  A 145 (-4.1A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.50A 4ogrI-5j5tA:
25.9		 4ogrI-5j5tA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
GLY A  28
VAL A  30
ALA A  43
VAL A  74
LEU A 143
ALA A 153
 None
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.38A 4otiA-5j5tA:
23.2		 4otiA-5j5tA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
LYS A  45
VAL A  74
LEU A 143
ALA A 153
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.49A 4otiA-5j5tA:
23.2		 4otiA-5j5tA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
LYS A  45
VAL A  74
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.76A 4otwA-5j5tA:
21.2		 4otwA-5j5tA:
26.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ILE A  22
ALA A  43
GLU A  61
ILE A  88
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.70A 4qmnA-5j5tA:
30.1		 4qmnA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ILE A  22
ALA A  43
LYS A  45
GLU A  61
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.79A 4qmnA-5j5tA:
30.1		 4qmnA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 11 ILE A  22
ALA A  43
LYS A  45
GLU A  61
ILE A  88
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.74A 4qmsA-5j5tA:
30.2		 4qmsA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  90
GLY A  94
LEU A 143
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
TPO  A 145 ( 4.9A)
6G2  A 901 (-4.7A)
 0.67A 4qmzA-5j5tA:
31.1		 4qmzA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
GLY A  23
VAL A  30
ALA A  43
GLY A  94
LEU A 143
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
TPO  A 145 ( 4.9A)
6G2  A 901 (-4.7A)
 0.49A 4qmzA-5j5tA:
31.1		 4qmzA-5j5tA:
38.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
GLU A  61
MET A  65
LEU A 127
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.80A 4qrcA-5j5tA:
22.2		 4qrcA-5j5tA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
CYH A  93
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
TPO  A 145 (-4.1A)
6G2  A 901 (-4.7A)
 0.66A 4r7iA-5j5tA:
20.8		 4r7iA-5j5tA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.82A 4rzvB-5j5tA:
22.7		 4rzvB-5j5tA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.65A 4twpA-5j5tA:
22.7		 4twpA-5j5tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 4twpB-5j5tA:
22.9		 4twpB-5j5tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.64A 4twpB-5j5tA:
22.9		 4twpB-5j5tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 4tyjA-5j5tA:
21.8		 4tyjA-5j5tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
LYS A  45
CYH A  93
GLY A  96
HIS A 134
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
 0.55A 4u0iA-5j5tA:
21.0		 4u0iA-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 11 PHE A 155
ASP A 154
ALA A 159
ILE A 137
ASP A 196
 None
6G2  A 901 (-3.4A)
None
None
None
 1.39A 4uuuA-5j5tA:
undetectable
4uuuB-5j5tA:
undetectable		 4uuuA-5j5tA:
17.84
4uuuB-5j5tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.60A 4uxqA-5j5tA:
21.7		 4uxqA-5j5tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  64
MET A  65
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.84A 4v01A-5j5tA:
21.2		 4v01A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
MET A  65
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.80A 4v01A-5j5tA:
21.2		 4v01A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  64
MET A  65
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
None
None
6G2  A 901 ( 4.2A)
 0.94A 4v01B-5j5tA:
21.4		 4v01B-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
GLU A  61
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.75A 4v04A-5j5tA:
21.0		 4v04A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
GLU A  61
MET A  64
HIS A 134
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.99A 4v04A-5j5tA:
21.0		 4v04A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
GLU A  61
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.68A 4v04B-5j5tA:
21.2		 4v04B-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 4wa9B-5j5tA:
22.1		 4wa9B-5j5tA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.62A 4wa9B-5j5tA:
22.1		 4wa9B-5j5tA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
MET A  65
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.56A 4xeyB-5j5tA:
22.1		 4xeyB-5j5tA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
VAL A  74
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.66A 4xliA-5j5tA:
23.0		 4xliA-5j5tA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.62A 4xliB-5j5tA:
23.2		 4xliB-5j5tA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
ASP A 154
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.4A)
None
 0.68A 4xv2A-5j5tA:
22.4		 4xv2A-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
LYS A  45
CYH A  93
ASP A 154
PHE A 155
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.4A)
None
 0.71A 4xv2B-5j5tA:
22.7		 4xv2B-5j5tA:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
PHE A  92
CYH A  93
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.97A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
PHE A  92
CYH A  93
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.49A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 GLY A  23
ALA A  43
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.66A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.68A 5bvwA-5j5tA:
21.1		 5bvwA-5j5tA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.70A 5cswA-5j5tA:
22.2		 5cswA-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.72A 5cswB-5j5tA:
22.1		 5cswB-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 GLY A  23
ARG A  21
TYR A  31
GLU A  61
LEU A 143
 None
None
None
None
6G2  A 901 (-4.7A)
 1.40A 5czyA-5j5tA:
undetectable		 5czyA-5j5tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
LYS A  45
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
None
None
 0.62A 5hi2A-5j5tA:
21.6		 5hi2A-5j5tA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
ALA A  43
LYS A  45
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.56A 5i9xA-5j5tA:
22.5		 5i9xA-5j5tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
ALA A  43
LYS A  45
MET A  65
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.76A 5i9yA-5j5tA:
22.5		 5i9yA-5j5tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		4 / 7 GLY A  23
VAL A  30
LYS A  45
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-3.4A)
 0.39A 5j5xA-5j5tA:
23.6		 5j5xA-5j5tA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
VAL A  74
LEU A 143
ALA A 153
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.64A 5l2iA-5j5tA:
20.9		 5l2iA-5j5tA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 GLY A  23
VAL A  30
ALA A  43
VAL A  74
ALA A 153
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.94A 5l2tA-5j5tA:
20.7		 5l2tA-5j5tA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
VAL A  74
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.86A 5l2tA-5j5tA:
20.7		 5l2tA-5j5tA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ILE A  22
GLY A  23
VAL A  30
ALA A  43
MET A  90
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
 0.26A 5lw1B-5j5tA:
20.9		 5lw1B-5j5tA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 10 VAL A  30
LYS A  45
GLU A  61
ILE A  88
PHE A  92
GLY A  96
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
 0.61A 5mo4A-5j5tA:
12.5		 5mo4A-5j5tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
MET A  65
VAL A  74
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 5mo4A-5j5tA:
12.5		 5mo4A-5j5tA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 8 ALA A  43
GLU A  61
CYH A  93
LEU A 143
ASP A 154
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.32A 5owrA-5j5tA:
32.1		 5owrA-5j5tA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
GLU A  61
MET A  65
VAL A  74
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.50A 5te0A-5j5tA:
22.2		 5te0A-5j5tA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
CYH A  93
GLY A  96
ASP A 100
ASP A 154
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.68A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
ALA A  43
GLU A  61
CYH A  93
GLY A  96
ASP A 100
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.83A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
GLY A  23
ALA A  43
CYH A  93
GLY A  96
ASP A 100
 6G2  A 901 (-3.8A)
None
6G2  A 901 (-3.2A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.59A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  94
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.9A)
 0.85A 5vcyA-5j5tA:
22.7		 5vcyA-5j5tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ALA A  43
VAL A  74
MET A  90
CYH A  93
GLY A  95
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.5A)
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.7A)
 0.97A 5w5vA-5j5tA:
9.7		 5w5vA-5j5tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ALA A  43
VAL A  74
MET A  90
CYH A  93
GLY A  96
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.5A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
 0.71A 5w5vA-5j5tA:
9.7		 5w5vA-5j5tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.49A 5y7zA-5j5tA:
14.0		 5y7zA-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.49A 5y7zA-5j5tA:
14.0		 5y7zA-5j5tA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.44A 5y7zB-5j5tA:
13.7		 5y7zB-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.46A 5y80A-5j5tA:
22.5		 5y80A-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
MET A  90
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.91A 5yu9D-5j5tA:
21.8		 5yu9D-5j5tA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		3 / 3 MET A  90
ASP A 154
ARG A  21
 6G2  A 901 (-3.5A)
6G2  A 901 (-3.4A)
None
 1.14A 5z6kA-5j5tA:
undetectable		 5z6kA-5j5tA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.55A 6bsdA-5j5tA:
20.9		 6bsdA-5j5tA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		3 / 3 TYR A 102
ASP A 100
GLN A  99
 None
6G2  A 901 (-4.7A)
None
 0.74A 6g1pA-5j5tA:
undetectable		 6g1pA-5j5tA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.72A 6hd4A-5j5tA:
20.8		 6hd4A-5j5tA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.71A 6hd4B-5j5tA:
20.8		 6hd4B-5j5tA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		10 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
PHE A  92
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 6hd6A-5j5tA:
20.9		 6hd6A-5j5tA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
PHE A  92
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-4.7A)
 0.73A 6hd6B-5j5tA:
20.9		 6hd6B-5j5tA:
12.23