SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6AK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 6dm8 -
(-) 		4 / 5 LEU A 248
ILE A 163
LEU A 160
SER A 159
 6AK  A 401 (-4.3A)
None
None
None
 0.88A 2byoA-6dm8A:
undetectable		 2byoA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 6dm8 -
(-) 		4 / 6 LEU A 167
TYR A 166
ILE A 275
GLY A 198
 None
None
6AK  A 401 ( 4.9A)
None
 0.91A 2du8B-6dm8A:
undetectable		 2du8B-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6dm8 -
(-) 		5 / 11 THR A-122
GLN A 110
ALA A 109
ALA A  88
ALA A  86
 None
6AK  A 403 (-4.0A)
6AK  A 403 (-3.4A)
None
6AK  A 403 ( 4.4A)
 1.16A 2f16H-6dm8A:
undetectable
2f16I-6dm8A:
undetectable		 2f16H-6dm8A:
undetectable
2f16I-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6dm8 -
(-) 		5 / 11 THR A-122
GLN A 110
ALA A 109
ALA A  88
ALA A  86
 None
6AK  A 403 (-4.0A)
6AK  A 403 (-3.4A)
None
6AK  A 403 ( 4.4A)
 1.14A 2f16V-6dm8A:
undetectable
2f16W-6dm8A:
undetectable		 2f16V-6dm8A:
undetectable
2f16W-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 6dm8 -
(-) 		4 / 7 VAL A-105
GLY A  85
PRO A  14
LYS A  90
 6AK  A 403 ( 4.9A)
None
None
6AK  A 403 ( 4.1A)
 0.72A 3bjwC-6dm8A:
undetectable		 3bjwC-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 6dm8 -
(-) 		4 / 8 VAL A-105
GLY A  85
PRO A  14
LYS A  90
 6AK  A 403 ( 4.9A)
None
None
6AK  A 403 ( 4.1A)
 0.95A 3bjwA-6dm8A:
undetectable		 3bjwA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 6dm8 -
(-) 		4 / 4 VAL A-105
ALA A-103
ILE A 102
THR A 105
 6AK  A 403 ( 4.9A)
None
None
None
 1.16A 5e4dB-6dm8A:
undetectable		 5e4dB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 6dm8 -
(-) 		4 / 6 GLY A 198
SER A 250
VAL A 246
HIS A 205
 None
None
None
6AK  A 401 ( 4.4A)
 0.99A 5ewuA-6dm8A:
undetectable		 5ewuA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 6dm8 -
(-) 		4 / 6 GLY A 198
SER A 250
VAL A 246
HIS A 205
 None
None
None
6AK  A 401 ( 4.4A)
 1.00A 5ewuB-6dm8A:
undetectable		 5ewuB-6dm8A:
undetectable