SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '65X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 (-4.4A)
65X  A 203 (-3.0A)
65X  A 203 (-3.9A)
None
 0.72A 1cbrA-5hz5A:
19.0		 1cbrA-5hz5A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 (-4.4A)
65X  A 203 (-3.0A)
65X  A 203 (-3.9A)
None
 0.72A 1cbrB-5hz5A:
19.0		 1cbrB-5hz5A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 (-4.4A)
65X  A 203 (-3.0A)
65X  A 203 (-3.9A)
None
 0.68A 1cbsA-5hz5A:
18.8		 1cbsA-5hz5A:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 (-4.4A)
65X  A 203 (-3.0A)
65X  A 203 (-3.9A)
None
 0.69A 2fr3A-5hz5A:
19.1		 2fr3A-5hz5A:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		9 / 12 PHE A  19
VAL A  28
SER A  58
THR A  63
ALA A  78
ASP A  79
ARG A  81
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
None
65X  A 203 ( 3.7A)
65X  A 203 ( 4.8A)
65X  A 203 (-3.5A)
65X  A 203 ( 4.2A)
None
65X  A 203 (-3.9A)
None
 0.60A 2qm9A-5hz5A:
23.9		 2qm9A-5hz5A:
47.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		4 / 4 TYR A  22
MET A  23
PRO A  41
ILE A 107
 65X  A 203 ( 4.7A)
65X  A 203 ( 3.9A)
65X  A 203 (-4.4A)
65X  A 203 (-3.9A)
 0.32A 2qm9A-5hz5A:
23.9		 2qm9A-5hz5A:
47.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		10 / 12 PHE A  19
TYR A  22
VAL A  28
SER A  58
THR A  63
ALA A  78
ARG A  81
ILE A 107
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 ( 4.7A)
None
65X  A 203 ( 3.7A)
65X  A 203 ( 4.8A)
65X  A 203 (-3.5A)
None
65X  A 203 (-3.9A)
65X  A 203 (-3.9A)
None
 0.59A 2qm9B-5hz5A:
24.6		 2qm9B-5hz5A:
47.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		4 / 4 MET A  23
PRO A  41
ASP A  79
ARG A 109
 65X  A 203 ( 3.9A)
65X  A 203 (-4.4A)
65X  A 203 ( 4.2A)
65X  A 203 (-4.0A)
 0.33A 2qm9B-5hz5A:
24.6		 2qm9B-5hz5A:
47.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		4 / 5 GLN A  64
THR A  63
GLU A  75
THR A  83
 None
65X  A 203 ( 4.8A)
None
None
 1.49A 3n58A-5hz5A:
undetectable		 3n58A-5hz5A:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		11 / 12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 109
VAL A 118
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 ( 3.9A)
None
65X  A 203 (-4.4A)
65X  A 203 ( 4.2A)
None
65X  A 203 (-3.9A)
65X  A 203 (-4.0A)
None
65X  A 203 (-3.9A)
None
 0.58A 3p6gA-5hz5A:
23.7		 3p6gA-5hz5A:
51.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		7 / 7 PHE A  19
MET A  23
ASP A  79
ILE A 107
VAL A 118
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 ( 3.9A)
65X  A 203 ( 4.2A)
65X  A 203 (-3.9A)
None
65X  A 203 (-3.9A)
None
 0.56A 3p6hA-5hz5A:
23.7		 3p6hA-5hz5A:
51.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		4 / 6 TYR A  22
GLU A  75
THR A  77
GLN A  98
 65X  A 203 ( 4.7A)
None
None
None
 0.60A 4qztA-5hz5A:
20.9		 4qztA-5hz5A:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		4 / 6 TYR A  22
GLU A  75
THR A  77
GLN A  98
 65X  A 203 ( 4.7A)
None
None
None
 0.59A 4qzuC-5hz5A:
20.9		 4qzuC-5hz5A:
28.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens) 		5 / 12 PHE A  19
TYR A  22
VAL A  28
LEU A  32
ILE A  54
 65X  A 203 ( 4.7A)
65X  A 203 ( 4.7A)
None
65X  A 203 (-3.6A)
None
 0.81A 5hbsA-5hz5A:
20.7		 5hbsA-5hz5A:
31.39