SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '64Z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_A_AG2A505_1 (HOMOSPERMIDINE SYNTHASE)	5hss	LINALOOL DEHYDRATASE/ISOMERAS E (Castellaniella defragrans)	5 / 12	GLU A 344 TRP A 53 TYR A 70 LEU A 341 THR A 58	None None None 64Z A 402 (-4.7A) None	1.45A	4xqeA-5hssA: undetectable	4xqeA-5hssA: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_B_AG2B504_1 (HOMOSPERMIDINE SYNTHASE)	5hss	LINALOOL DEHYDRATASE/ISOMERAS E (Castellaniella defragrans)	5 / 12	GLU A 344 TRP A 53 TYR A 70 LEU A 341 THR A 58	None None None 64Z A 402 (-4.7A) None	1.45A	4xqeB-5hssA: undetectable	4xqeB-5hssA: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XRG_A_AG2A502_1 (HOMOSPERMIDINE SYNTHASE)	5hss	LINALOOL DEHYDRATASE/ISOMERAS E (Castellaniella defragrans)	5 / 12	GLU A 344 TRP A 53 TYR A 70 LEU A 341 THR A 58	None None None 64Z A 402 (-4.7A) None	1.45A	4xrgA-5hssA: undetectable	4xrgA-5hssA: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XRG_B_AG2B502_1 (HOMOSPERMIDINE SYNTHASE)	5hss	LINALOOL DEHYDRATASE/ISOMERAS E (Castellaniella defragrans)	5 / 12	GLU A 344 TRP A 53 TYR A 70 LEU A 341 THR A 58	None None None 64Z A 402 (-4.7A) None	1.46A	4xrgB-5hssA: undetectable	4xrgB-5hssA: 22.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4XQE_A_AG2A505_1","HOMOSPERMIDINE SYNTHASE","5hss","LINALOOL DEHYDRATASE\/ISOMERASE","Castellaniella defragrans",5,"GLU A 344;TRP A  53;TYR A  70;LEU A 341;THR A  58","None;None;None;64Z A 402 (-4.7A);None","1.45A","4xqeA-5hssA:undetectable",null],["4XQE_B_AG2B504_1","HOMOSPERMIDINE SYNTHASE","5hss","LINALOOL DEHYDRATASE\/ISOMERASE","Castellaniella defragrans",5,"GLU A 344;TRP A  53;TYR A  70;LEU A 341;THR A  58","None;None;None;64Z A 402 (-4.7A);None","1.45A","4xqeB-5hssA:undetectable","4xqeA-5hssA:22.36"],["4XRG_A_AG2A502_1","HOMOSPERMIDINE SYNTHASE","5hss","LINALOOL DEHYDRATASE\/ISOMERASE","Castellaniella defragrans",5,"GLU A 344;TRP A  53;TYR A  70;LEU A 341;THR A  58","None;None;None;64Z A 402 (-4.7A);None","1.45A","4xrgA-5hssA:undetectable","4xqeB-5hssA:22.36"],["4XRG_B_AG2B502_1","HOMOSPERMIDINE SYNTHASE","5hss","LINALOOL DEHYDRATASE\/ISOMERASE","Castellaniella defragrans",5,"GLU A 344;TRP A  53;TYR A  70;LEU A 341;THR A  58","None;None;None;64Z A 402 (-4.7A);None","1.46A","4xrgB-5hssA:undetectable","4xrgA-5hssA:22.36"]]