SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '64K'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 7 GLY A 131
THR A 298
GLN A 269
PHE A  44
 None
None
64K  A 401 (-2.8A)
64K  A 401 ( 4.2A)
 1.07A 2qx4A-5hqjA:
2.5
2qx4B-5hqjA:
4.7		 2qx4A-5hqjA:
20.75
2qx4B-5hqjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 7 GLY A 131
THR A 298
PHE A  43
PHE A  44
 None
None
64K  A 401 ( 2.8A)
64K  A 401 ( 4.2A)
 1.18A 2qx4A-5hqjA:
2.5
2qx4B-5hqjA:
4.7		 2qx4A-5hqjA:
20.75
2qx4B-5hqjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		3 / 3 LYS A  38
ILE A 158
PHE A 217
 64K  A 401 (-2.5A)
None
None
 0.94A 3j7zS-5hqjA:
undetectable
3j7za-5hqjA:
undetectable		 3j7zS-5hqjA:
18.12
3j7za-5hqjA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 8 PRO A  67
PHE A  44
TRP A  64
TYR A  62
 None
64K  A 401 ( 4.2A)
None
None
 1.04A 4v2zC-5hqjA:
undetectable		 4v2zC-5hqjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 12 LEU A 251
ASN A  95
ASP A 118
ASN A 166
PHE A 248
 None
None
64K  A 401 (-2.7A)
64K  A 401 (-2.6A)
64K  A 401 ( 4.9A)
 1.36A 5dv4A-5hqjA:
undetectable		 5dv4A-5hqjA:
22.76