SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '63K'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | VAL A1092ALA A1108LEU A1140LEU A1195HIS A1202 | 63K A1401 (-4.9A)63K A1401 (-3.5A)NoneNoneNone | 0.52A | 1uwjA-5horA:7.4 | 1uwjA-5horA:30.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2WGJ_A_VGHA2346_1 (HEPATOCYTE GROWTHFACTOR RECEPTOR) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 10 / 12 | VAL A1092ALA A1108LEU A1140LEU A1157TYR A1159MET A1160GLY A1163MET A1211ALA A1221ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)None63K A1401 (-4.2A)63K A1401 (-3.5A)None63K A1401 (-3.6A)63K A1401 (-4.0A)63K A1401 (-3.3A)None | 0.43A | 2wgjA-5horA:33.2 | 2wgjA-5horA:96.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2XP2_A_VGHA9000_1 (TYROSINE-PROTEINKINASE RECEPTOR) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A1092ALA A1108LEU A1157MET A1160GLY A1163ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)63K A1401 (-4.2A)None63K A1401 (-3.6A)None | 0.62A | 2xp2A-5horA:13.6 | 2xp2A-5horA:33.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_A_NILA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108GLY A1163PHE A1200HIS A1202ALA A1221 | 63K A1401 (-3.5A)63K A1401 (-3.6A)NoneNone63K A1401 (-3.3A) | 0.44A | 3cs9A-5horA:26.7 | 3cs9A-5horA:38.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_C_NILC600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108MET A1131PHE A1200HIS A1202ALA A1221 | 63K A1401 (-3.5A)NoneNoneNone63K A1401 (-3.3A) | 0.75A | 3cs9C-5horA:28.9 | 3cs9C-5horA:38.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_C_NILC600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108PHE A1200HIS A1202ALA A1221ASP A1222 | 63K A1401 (-3.5A)NoneNone63K A1401 (-3.3A)None | 0.91A | 3cs9C-5horA:28.9 | 3cs9C-5horA:38.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108GLY A1163PHE A1200HIS A1202ALA A1221 | 63K A1401 (-3.5A)63K A1401 (-3.6A)NoneNone63K A1401 (-3.3A) | 0.52A | 3cs9D-5horA:26.5 | 3cs9D-5horA:38.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | MET A1131GLY A1163PHE A1200HIS A1202ALA A1221 | None63K A1401 (-3.6A)NoneNone63K A1401 (-3.3A) | 0.65A | 3cs9D-5horA:26.5 | 3cs9D-5horA:38.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | VAL A1092ALA A1108LEU A1140PHE A1223GLY A1224 | 63K A1401 (-4.9A)63K A1401 (-3.5A)NoneNoneNone | 0.54A | 3og7A-5horA:26.0 | 3og7A-5horA:29.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_2 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 3 / 3 | LEU A1157MET A1160ASP A1164 | 63K A1401 (-4.2A)None63K A1401 (-4.0A) | 0.50A | 3v5wA-5horA:7.2 | 3v5wA-5horA:17.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZBF_A_VGHA3000_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108LEU A1140LEU A1157MET A1160GLY A1163ASP A1164 | 63K A1401 (-3.5A)None63K A1401 (-4.2A)None63K A1401 (-3.6A)63K A1401 (-4.0A) | 0.42A | 3zbfA-5horA:28.0 | 3zbfA-5horA:36.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZBF_A_VGHA3000_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108LEU A1140MET A1160GLY A1163ASP A1164ASP A1222 | 63K A1401 (-3.5A)NoneNone63K A1401 (-3.6A)63K A1401 (-4.0A)None | 0.50A | 3zbfA-5horA:28.0 | 3zbfA-5horA:36.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANQ_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 9 | VAL A1092ALA A1108LEU A1157MET A1160GLY A1163ALA A1221ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)63K A1401 (-4.2A)None63K A1401 (-3.6A)63K A1401 (-3.3A)None | 0.62A | 4anqA-5horA:25.7 | 4anqA-5horA:32.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANS_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A1092ALA A1108MET A1160GLY A1163ALA A1221ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)None63K A1401 (-3.6A)63K A1401 (-3.3A)None | 0.59A | 4ansA-5horA:25.7 | 4ansA-5horA:33.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4QRC_A_0LIA802_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108MET A1131LEU A1195ARG A1203ALA A1221 | 63K A1401 (-3.5A)NoneNoneNone63K A1401 (-3.3A) | 1.05A | 4qrcA-5horA:24.7 | 4qrcA-5horA:32.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | VAL A1092ALA A1108LEU A1140PHE A1223GLY A1224 | 63K A1401 (-4.9A)63K A1401 (-3.5A)NoneNoneNone | 0.63A | 4rzvB-5horA:25.9 | 4rzvB-5horA:29.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_B_RXTB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A1092ALA A1108TYR A1159MET A1160GLY A1163ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)63K A1401 (-3.5A)None63K A1401 (-3.6A)None | 0.58A | 4u5jB-5horA:9.1 | 4u5jB-5horA:36.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108MET A1131LEU A1195HIS A1202ALA A1221 | 63K A1401 (-3.5A)NoneNoneNone63K A1401 (-3.3A) | 0.61A | 4v01A-5horA:27.3 | 4v01A-5horA:35.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_B_0LIB1770_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108MET A1131LEU A1195HIS A1202ALA A1221 | 63K A1401 (-3.5A)NoneNoneNone63K A1401 (-3.3A) | 0.60A | 4v01B-5horA:27.1 | 4v01B-5horA:35.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_A_0LIA1772_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108LEU A1195HIS A1202ALA A1221GLY A1224 | 63K A1401 (-4.9A)63K A1401 (-3.5A)NoneNone63K A1401 (-3.3A)None | 0.83A | 4v04A-5horA:26.0 | 4v04A-5horA:35.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108LEU A1195HIS A1202ALA A1221GLY A1224 | 63K A1401 (-3.5A)NoneNone63K A1401 (-3.3A)None | 0.89A | 4v04B-5horA:26.5 | 4v04B-5horA:35.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WA9_A_AXIA9000_1 (TYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 11 | ALA A1108LYS A1110MET A1160GLY A1163ASN A1209ALA A1221 | 63K A1401 (-3.5A)NoneNone63K A1401 (-3.6A)None63K A1401 (-3.3A) | 0.84A | 4wa9A-5horA:22.9 | 4wa9A-5horA:37.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAA_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A1092ALA A1108LEU A1157MET A1160GLY A1163ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)63K A1401 (-4.2A)None63K A1401 (-3.6A)None | 0.63A | 5aaaA-5horA:24.8 | 5aaaA-5horA:33.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAC_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 10 | VAL A1092ALA A1108LYS A1110LEU A1157MET A1160GLY A1163ASP A1222 | 63K A1401 (-4.9A)63K A1401 (-3.5A)None63K A1401 (-4.2A)None63K A1401 (-3.6A)None | 0.71A | 5aacA-5horA:28.3 | 5aacA-5horA:33.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HES_A_032A401_1 (MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | VAL A1092ALA A1108TYR A1159PHE A1223GLY A1224 | 63K A1401 (-4.9A)63K A1401 (-3.5A)63K A1401 (-3.5A)NoneNone | 0.69A | 5hesA-5horA:11.1 | 5hesA-5horA:28.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MO4_A_NILA601_2 (TYROSINE-PROTEINKINASE ABL1) |
5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108MET A1131PHE A1200HIS A1202ALA A1221 | 63K A1401 (-3.5A)NoneNoneNone63K A1401 (-3.3A) | 0.72A | 5mo4A-5horA:5.6 | 5mo4A-5horA:27.52 |