SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '63K'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 VAL A1092
ALA A1108
LEU A1140
LEU A1195
HIS A1202
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
0.52A 1uwjA-5horA:
7.4
1uwjA-5horA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
10 / 12 VAL A1092
ALA A1108
LEU A1140
LEU A1157
TYR A1159
MET A1160
GLY A1163
MET A1211
ALA A1221
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
63K  A1401 (-4.2A)
63K  A1401 (-3.5A)
None
63K  A1401 (-3.6A)
63K  A1401 (-4.0A)
63K  A1401 (-3.3A)
None
0.43A 2wgjA-5horA:
33.2
2wgjA-5horA:
96.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A1092
ALA A1108
LEU A1157
MET A1160
GLY A1163
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
None
0.62A 2xp2A-5horA:
13.6
2xp2A-5horA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
GLY A1163
PHE A1200
HIS A1202
ALA A1221
63K  A1401 (-3.5A)
63K  A1401 (-3.6A)
None
None
63K  A1401 (-3.3A)
0.44A 3cs9A-5horA:
26.7
3cs9A-5horA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
MET A1131
PHE A1200
HIS A1202
ALA A1221
63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
0.75A 3cs9C-5horA:
28.9
3cs9C-5horA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
PHE A1200
HIS A1202
ALA A1221
ASP A1222
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.3A)
None
0.91A 3cs9C-5horA:
28.9
3cs9C-5horA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
GLY A1163
PHE A1200
HIS A1202
ALA A1221
63K  A1401 (-3.5A)
63K  A1401 (-3.6A)
None
None
63K  A1401 (-3.3A)
0.52A 3cs9D-5horA:
26.5
3cs9D-5horA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 MET A1131
GLY A1163
PHE A1200
HIS A1202
ALA A1221
None
63K  A1401 (-3.6A)
None
None
63K  A1401 (-3.3A)
0.65A 3cs9D-5horA:
26.5
3cs9D-5horA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 VAL A1092
ALA A1108
LEU A1140
PHE A1223
GLY A1224
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
0.54A 3og7A-5horA:
26.0
3og7A-5horA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
3 / 3 LEU A1157
MET A1160
ASP A1164
63K  A1401 (-4.2A)
None
63K  A1401 (-4.0A)
0.50A 3v5wA-5horA:
7.2
3v5wA-5horA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
LEU A1140
LEU A1157
MET A1160
GLY A1163
ASP A1164
63K  A1401 (-3.5A)
None
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
63K  A1401 (-4.0A)
0.42A 3zbfA-5horA:
28.0
3zbfA-5horA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
LEU A1140
MET A1160
GLY A1163
ASP A1164
ASP A1222
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.6A)
63K  A1401 (-4.0A)
None
0.50A 3zbfA-5horA:
28.0
3zbfA-5horA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 9 VAL A1092
ALA A1108
LEU A1157
MET A1160
GLY A1163
ALA A1221
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
63K  A1401 (-3.3A)
None
0.62A 4anqA-5horA:
25.7
4anqA-5horA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A1092
ALA A1108
MET A1160
GLY A1163
ALA A1221
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
63K  A1401 (-3.6A)
63K  A1401 (-3.3A)
None
0.59A 4ansA-5horA:
25.7
4ansA-5horA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
MET A1131
LEU A1195
ARG A1203
ALA A1221
63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
1.05A 4qrcA-5horA:
24.7
4qrcA-5horA:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 VAL A1092
ALA A1108
LEU A1140
PHE A1223
GLY A1224
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
0.63A 4rzvB-5horA:
25.9
4rzvB-5horA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A1092
ALA A1108
TYR A1159
MET A1160
GLY A1163
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-3.5A)
None
63K  A1401 (-3.6A)
None
0.58A 4u5jB-5horA:
9.1
4u5jB-5horA:
36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
MET A1131
LEU A1195
HIS A1202
ALA A1221
63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
0.61A 4v01A-5horA:
27.3
4v01A-5horA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
MET A1131
LEU A1195
HIS A1202
ALA A1221
63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
0.60A 4v01B-5horA:
27.1
4v01B-5horA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
LEU A1195
HIS A1202
ALA A1221
GLY A1224
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.3A)
None
0.83A 4v04A-5horA:
26.0
4v04A-5horA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
LEU A1195
HIS A1202
ALA A1221
GLY A1224
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.3A)
None
0.89A 4v04B-5horA:
26.5
4v04B-5horA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 11 ALA A1108
LYS A1110
MET A1160
GLY A1163
ASN A1209
ALA A1221
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.6A)
None
63K  A1401 (-3.3A)
0.84A 4wa9A-5horA:
22.9
4wa9A-5horA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A1092
ALA A1108
LEU A1157
MET A1160
GLY A1163
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
None
0.63A 5aaaA-5horA:
24.8
5aaaA-5horA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 10 VAL A1092
ALA A1108
LYS A1110
LEU A1157
MET A1160
GLY A1163
ASP A1222
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
None
0.71A 5aacA-5horA:
28.3
5aacA-5horA:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 VAL A1092
ALA A1108
TYR A1159
PHE A1223
GLY A1224
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-3.5A)
None
None
0.69A 5hesA-5horA:
11.1
5hesA-5horA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
MET A1131
PHE A1200
HIS A1202
ALA A1221
63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
0.72A 5mo4A-5horA:
5.6
5mo4A-5horA:
27.52