SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5XE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO A 583
PHE A 587
ALA A 651
 None
5XE  A 705 (-4.4A)
None
 0.71A 3itaD-5fg6A:
undetectable		 3itaD-5fg6A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A 591
VAL A 596
TYR A 599
ASN A 642
 5XE  A 705 (-3.9A)
5XE  A 705 (-4.9A)
None
5XE  A 705 (-3.3A)
 0.37A 5pbeA-5fg6A:
15.3		 5pbeA-5fg6A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 591
CYH A 638
TYR A 641
ASN A 642
 5XE  A 705 (-3.9A)
5XE  A 705 (-3.6A)
5XE  A 705 (-4.8A)
5XE  A 705 (-3.3A)
 0.36A 5y1yA-5fg6A:
13.7		 5y1yA-5fg6A:
32.61