SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5WP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_A_SAMA293_1 (GLYCINE N-METHYLTRANSFERASE)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	3 / 3	ARG A 666 ASP A 391 ASN A 752	5WP A 901 (-2.8A) None None	0.90A	1nbhA-5fbuA: undetectable	1nbhA-5fbuA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_D_SAMD3293_1 (GLYCINE N-METHYLTRANSFERASE)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	3 / 3	ARG A 666 ASP A 391 ASN A 752	5WP A 901 (-2.8A) None None	0.88A	1nbhD-5fbuA: undetectable	1nbhD-5fbuA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UVN_A_ECNA1409_1 (CYTOCHROME P450 130)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	5 / 12	LEU A 387 PRO A 392 GLY A 821 GLY A 820 THR A 824	5WP A 901 (-4.3A) None None None None	1.13A	2uvnA-5fbuA: undetectable	2uvnA-5fbuA: 20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HV1_A_RFPA902_1 (PHOSPHOENOLPYRUVATE SYNTHASE)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	11 / 12	VAL A 333 TYR A 351 PRO A 356 ALA A 357 VAL A 368 LEU A 387 SER A 390 LEU A 478 ILE A 487 MET A 488 MET A 491	5WP A 901 (-3.6A) 5WP A 901 (-4.5A) 5WP A 901 (-4.3A) 5WP A 901 ( 4.0A) 5WP A 901 (-4.5A) 5WP A 901 (-4.3A) 5WP A 901 ( 3.7A) 5WP A 901 (-4.7A) None 5WP A 901 (-4.2A) 5WP A 901 (-3.6A)	0.51A	5hv1A-5fbuA: 51.3	5hv1A-5fbuA: 98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HV1_A_RFPA902_1 (PHOSPHOENOLPYRUVATE SYNTHASE)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	6 / 12	VAL A 333 TYR A 351 VAL A 368 LEU A 387 ILE A 484 MET A 488	5WP A 901 (-3.6A) 5WP A 901 (-4.5A) 5WP A 901 (-4.5A) 5WP A 901 (-4.3A) None 5WP A 901 (-4.2A)	1.06A	5hv1A-5fbuA: 51.3	5hv1A-5fbuA: 98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HV1_A_RFPA902_1 (PHOSPHOENOLPYRUVATE SYNTHASE)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	6 / 12	VAL A 333 TYR A 351 VAL A 368 LEU A 387 LEU A 478 ILE A 484	5WP A 901 (-3.6A) 5WP A 901 (-4.5A) 5WP A 901 (-4.5A) 5WP A 901 (-4.3A) 5WP A 901 (-4.7A) None	1.32A	5hv1A-5fbuA: 51.3	5hv1A-5fbuA: 98.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_I_PCFI101_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT 9 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	5 / 11	ASP A 341 TYR A 800 VAL A 819 GLY A 821 SER A 390	None None None None 5WP A 901 ( 3.7A)	1.40A	6hu9A-5fbuA: undetectable 6hu9E-5fbuA: 1.8 6hu9I-5fbuA: undetectable	6hu9A-5fbuA: 19.72 6hu9E-5fbuA: 12.83 6hu9I-5fbuA: 6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_T_PCFT101_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT 9 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL)	5fbu	PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes)	5 / 10	ASP A 341 TYR A 800 VAL A 819 GLY A 821 SER A 390	None None None None 5WP A 901 ( 3.7A)	1.38A	6hu9L-5fbuA: undetectable 6hu9P-5fbuA: undetectable 6hu9T-5fbuA: undetectable	6hu9L-5fbuA: 19.72 6hu9P-5fbuA: 12.83 6hu9T-5fbuA: 6.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NBH_A_SAMA293_1","GLYCINE N-METHYLTRANSFERASE","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",3,"ARG A 666;ASP A 391;ASN A 752","5WP A 901 (-2.8A);None;None","0.90A","1nbhA-5fbuA:undetectable",null],["1NBH_D_SAMD3293_1","GLYCINE N-METHYLTRANSFERASE","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",3,"ARG A 666;ASP A 391;ASN A 752","5WP A 901 (-2.8A);None;None","0.88A","1nbhD-5fbuA:undetectable","1nbhA-5fbuA:16.78"],["2UVN_A_ECNA1409_1","CYTOCHROME P450 130","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",5,"LEU A 387;PRO A 392;GLY A 821;GLY A 820;THR A 824","5WP A 901 (-4.3A);None;None;None;None","1.13A","2uvnA-5fbuA:undetectable","1nbhD-5fbuA:16.78"],["5HV1_A_RFPA902_1","PHOSPHOENOLPYRUVATE SYNTHASE","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",11,"VAL A 333;TYR A 351;PRO A 356;ALA A 357;VAL A 368;LEU A 387;SER A 390;LEU A 478;ILE A 487;MET A 488;MET A 491","5WP A 901 (-3.6A);5WP A 901 (-4.5A);5WP A 901 (-4.3A);5WP A 901 ( 4.0A);5WP A 901 (-4.5A);5WP A 901 (-4.3A);5WP A 901 ( 3.7A);5WP A 901 (-4.7A);None;5WP A 901 (-4.2A);5WP A 901 (-3.6A)","0.51A","5hv1A-5fbuA:51.3","2uvnA-5fbuA:20.12"],["5HV1_A_RFPA902_1","PHOSPHOENOLPYRUVATE SYNTHASE","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",6,"VAL A 333;TYR A 351;VAL A 368;LEU A 387;ILE A 484;MET A 488","5WP A 901 (-3.6A);5WP A 901 (-4.5A);5WP A 901 (-4.5A);5WP A 901 (-4.3A);None;5WP A 901 (-4.2A)","1.06A","5hv1A-5fbuA:51.3","5hv1A-5fbuA:98.19"],["5HV1_A_RFPA902_1","PHOSPHOENOLPYRUVATE SYNTHASE","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",6,"VAL A 333;TYR A 351;VAL A 368;LEU A 387;LEU A 478;ILE A 484","5WP A 901 (-3.6A);5WP A 901 (-4.5A);5WP A 901 (-4.5A);5WP A 901 (-4.3A);5WP A 901 (-4.7A);None","1.32A","5hv1A-5fbuA:51.3","5hv1A-5fbuA:98.19"],["6HU9_I_PCFI101_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL;CYTOCHROME B-C1 COMPLEX SUBUNIT 9;CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",5,"ASP A 341;TYR A 800;VAL A 819;GLY A 821;SER A 390","None;None;None;None;5WP A 901 ( 3.7A)","1.40A","6hu9A-5fbuA:undetectable;6hu9E-5fbuA:1.8;6hu9I-5fbuA:undetectable","5hv1A-5fbuA:98.19"],["6HU9_T_PCFT101_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL;CYTOCHROME B-C1 COMPLEX SUBUNIT 9;CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL","5fbu","PHOSPHOENOLPYRUVATE SYNTHASE","Listeria monocytogenes",5,"ASP A 341;TYR A 800;VAL A 819;GLY A 821;SER A 390","None;None;None;None;5WP A 901 ( 3.7A)","1.38A","6hu9L-5fbuA:undetectable;6hu9P-5fbuA:undetectable;6hu9T-5fbuA:undetectable","6hu9A-5fbuA:19.72;6hu9E-5fbuA:12.83;6hu9I-5fbuA:6.35"]]