SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5VT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		5 / 9 ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 226
 5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
5VT  A 302 ( 4.3A)
 0.88A 1bcuH-5fahA:
16.3		 1bcuH-5fahA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		5 / 9 ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
 0.44A 1bcuH-5fahA:
16.3		 1bcuH-5fahA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		4 / 6 SER A 195
VAL A 213
GLY A 216
GLY A 226
 5VT  A 302 (-4.0A)
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
 0.74A 1tnlA-5fahA:
18.2		 1tnlA-5fahA:
41.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5fah KALLIKREIN-7
(Homo
sapiens) 		6 / 12 ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
5VT  A 302 ( 4.3A)
None
 0.85A 2p16A-5fahA:
14.1		 2p16A-5fahA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5fah KALLIKREIN-7
(Homo
sapiens) 		6 / 12 ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
None
 0.41A 2p16A-5fahA:
14.1		 2p16A-5fahA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		6 / 12 ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
5VT  A 302 ( 4.3A)
None
 0.78A 2w26A-5fahA:
12.6		 2w26A-5fahA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		6 / 12 ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
None
 0.45A 2w26A-5fahA:
12.6		 2w26A-5fahA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 5VT  A 302 (-4.0A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
 0.82A 3rxfA-5fahA:
16.2		 3rxfA-5fahA:
43.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		4 / 5 HIS A  57
SER A 195
SER A 214
VAL A 213
 5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
 1.40A 4a99D-5fahA:
undetectable		 4a99D-5fahA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5fah KALLIKREIN-7
(Homo
sapiens) 		5 / 12 ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
 0.90A 4rn6B-5fahA:
25.9		 4rn6B-5fahA:
30.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 5fah KALLIKREIN-7
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
5VT  A 302 (-3.5A)
None
None
 1.34A 5eiwC-5fahA:
undetectable		 5eiwC-5fahA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5fah KALLIKREIN-7
(Homo
sapiens) 		3 / 3 LYS A  84
GLN A  39
ASN A  38
 None
5VT  A 302 (-4.4A)
None
 1.08A 5l2tA-5fahA:
undetectable		 5l2tA-5fahA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5fah KALLIKREIN-7
(Homo
sapiens) 		5 / 12 VAL A 138
ALA A 190
LEU A 103
LEU A  53
VAL A  45
 None
5VT  A 302 (-3.8A)
None
None
None
 1.16A 5tudA-5fahA:
undetectable		 5tudA-5fahA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5fah KALLIKREIN-7
(Homo
sapiens) 		5 / 12 VAL A 138
SER A 139
ALA A 190
LEU A  53
VAL A  45
 None
None
5VT  A 302 (-3.8A)
None
None
 1.09A 5tudA-5fahA:
undetectable		 5tudA-5fahA:
19.00