SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5V4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 4 LEU A 311
SER A 300
ASP A 175
ASP A 336
 None
None
5V4  A 408 (-3.0A)
None
 1.38A 2br4B-5f4zA:
undetectable		 2br4B-5f4zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 TRP A 179
SER A 300
TRP A  99
LEU A 176
 5V4  A 408 (-3.8A)
None
None
None
 0.95A 2o01A-5f4zA:
undetectable		 2o01A-5f4zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 176
ALA A 338
GLY A 174
THR A 183
ILE A 307
 None
5V4  A 408 (-3.5A)
None
None
None
 1.04A 3c6gA-5f4zA:
undetectable		 3c6gA-5f4zA:
22.24