SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5UF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 11 SER A 149
LEU A 264
ILE A 153
ALA A 154
LEU A 359
 None
None
None
5UF  A 401 ( 4.9A)
None
 1.44A 2v0mA-5f2oA:
undetectable		 2v0mA-5f2oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 0.86A 2wx2A-5f2oA:
undetectable		 2wx2A-5f2oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 8 PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 0.87A 3khmA-5f2oA:
undetectable		 3khmA-5f2oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 8 PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 0.64A 3l4dD-5f2oA:
undetectable		 3l4dD-5f2oA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 PHE A 336
PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 1.10A 5tl8A-5f2oA:
undetectable		 5tl8A-5f2oA:
22.20